DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Aldh-III and Aldh1l1

DIOPT Version :9

Sequence 1:	NP_724562.2	Gene:	Aldh-III / 45398	FlyBaseID:	FBgn0010548	Length:	564	Species:	Drosophila melanogaster
Sequence 2:	NP_001343341.1	Gene:	Aldh1l1 / 107747	MGIID:	1340024	Length:	902	Species:	Mus musculus

Alignment Length:	470	Identity:	125/470 - (26%)
Similarity:	204/470 - (43%)	Gaps:	71/470 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    66 RMANFDDTLQRARLAFSSG--KTRNVSFRRKQLENLLRCYEEHENEI--ISALEADLRRPKQESL 126
            ::::.|..:..|:.||.:|  ...|...|.:.|..|....|:|:.|:  |.||:|.
Mouse   457 QVSDVDKAVAAAKEAFENGLWGKINARDRGRLLYRLADLMEQHQEELATIEALDAG--------- 512

  Fly   127 IVETEFMKNDIRHILFQLDEWVQSEKPPKSFVNMMDDVQ-----------------IYNDPFGVV 174
            .|.|..:|.   |:...:..:       :.|....|.:|                 ...:|.||.
Mouse   513 AVYTLALKT---HVGMSIQTF-------RYFAGWCDKIQGATIPINQARPNRNLTLTKKEPVGVC 567

  Fly   175 LVIGAWNYPLQLLLVPVASAIAAGNCVVIKPSEIAANCAKFIADV-----IPKYLDNDCYPVVCG 234
            .::..|||||.:|....|:.:||||.|||||:::....|...|::     |||.:.|    ::.|
Mouse   568 GIVIPWNYPLMMLSWKTAACLAAGNTVVIKPAQVTPLTALKFAELTLKAGIPKGVVN----ILPG 628

  Fly   235 GPSETAELLNQRFDY--IFYTGSTRVGK-IIHAAANKYLTPTTLELGGKSPCYIDKSVDMRTAVK 296
            ..|...:.|:...|.  |.:||||.||| |:.:.|...:...:||||||||..|....|:..||:
Mouse   629 SGSLVGQRLSDHPDVRKIGFTGSTEVGKHIMKSCALSNVKKVSLELGGKSPLIIFADCDLNKAVQ 693

  Fly   297 RILWGKLINCGQTCIAPDYILCSKEVQEKFIVE-AKDVLKEWYGENIQSSPDLSRVINANNFQRL 360
            ..:.....|.|:.|||...:.....:.::|:.: .::|.|...|..:....:.....:..:.::|
Mouse   694 MGMSSVFFNKGENCIAAGRLFVEDSIHDQFVQKVVEEVGKMKIGNPLDRDTNHGPQNHEAHLRKL 758

  Fly   361 L-----GLMKSGRVAVGGN-YDASERFIEPTILVDVKETDPIMEEEIFGPILPIFN-VESAYDAI 418
            :     |:.:...:..||| ......|.:||:..||::...|.:||.||||:.|.. .:...||:
Mouse   759 VEYCQRGVKEGATLVCGGNQVPRPGFFFQPTVFTDVEDHMYIAKEESFGPIMIISRFADGDVDAV 823

  Fly   419 -KFINAREKPLVIYVFS---NSNKLVKEFRRSTTSGGFSSNETIMHCGVDV-LPFGGVGMSGMGR 478
             ...||.|..|...||:   |....|.:..::.|....:.|:|      || .||||...||.|:
Mouse   824 LSRANATEFGLASGVFTRDINKALYVSDKLQAGTVFVNTYNKT------DVAAPFGGFKQSGFGK 882

  Fly   479 YHGKYGFETFTHKKS 493
            ..|:.....:...|:
Mouse   883 DLGEAALNEYLRIKT 897

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Aldh-III	NP_724562.2	ALDH_F3AB	72..515	CDD:143450	124/464 (27%)
Aldh1l1	NP_001343341.1	FMT_core_FDH_N	1..203	CDD:187716
		GART	1..203
		Substrate binding. /evidence=ECO:0000250	88..90
		FDH_Hydrolase_C	206..306	CDD:187731
		PP-binding	325..391	CDD:306928
		ALDH_F1L_FTFDH	417..902	CDD:143458	125/470 (27%)
		Aldehyde dehydrogenase	417..902		125/470 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG1012
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900