Protein Alignment E5 and NKX6-2

DIOPT Version :9

• Sequence 1: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_796374.2
• Gene: NKX6-2 / 84504
• HGNCID: 19321
• Length: 277
• Species: Homo sapiens
• Alignment Length: 214
• Identity: 72/214 - (33%)
• Similarity: 91/214 - (42%)
• Gaps: 42/214 - (19%)

  Fly   224 VPTGPPHGPHPHLPPGQIPLGIFPGGPHPGHPPPHGHHP-----FGSAPHLIRDSYPLYPWLLSR 283
            :|.|.|||....|  |: |:|...||...|.|..:|...     ||.|..:.|.    ||..|:.
Human    52 LPLGTPHGISDIL--GR-PVGAAGGGLLGGLPRLNGLASSAGVYFGPAAAVARG----YPKPLAE 109

  Fly   284 -HGR--IFPRFPGNFLFQPFRKP------------------KRVRTAFSPTQLLKLEHAFEGNHY 327
             .||  ||  :||.....|:|.|                  |..|..||..|:..||..||...|
Human   110 LPGRPPIF--WPGVVQGAPWRDPRLAGPAPAGGVLDKDGKKKHSRPTFSGQQIFALEKTFEQTKY 172

  Fly   328 VVGAERKQLAQGLSLTETQVKVWFQNRRTKHKRMQQEGGDGSDTKSNKGSSSGGGGGGDGEDDAK 392
            :.|.||.:||..|.:||:||||||||||||.::........:..|.:..:.....||.|.|||
Human   173 LAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAVEMASAKKKQDSDAEKLKVGGSDAEDD-- 235

  Fly   393 HDGSQHSYEDAEDPEDEDE 411
                 ..|....||..:||
Human   236 -----DEYNRPLDPNSDDE 249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeobox	307..359	CDD:278475	29/51 (57%)
NKX6-2	NP_796374.2	Repressor domain. /evidence=ECO:0000250|UniProtKB:D3Z4R4	89..142		16/58 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..155		2/22 (9%)
		Homeobox	151..204	CDD:306543	29/52 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..250		12/47 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.810