Protein Alignment E5 and NKX2-1

DIOPT Version :10

• Sequence 1: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_001073136.1
• Gene: NKX2-1 / 7080
• HGNCID: 11825
• Length: 401
• Species: Homo sapiens
• Alignment Length: 440
• Identity: 101/440 - (22%)
• Similarity: 144/440 - (32%)
• Gaps: 142/440 - (32%)

  Fly   129 AGGNPAAAGNTAKSGDPSSGTGNPPTLIR---------------------PLP------------ 160
            :||:..|.|..|.:|    |..:|..|.|                     ||.
Human     3 SGGSGKARGWEAAAG----GRSSPGRLSRRRIMSMSPKHTTPFSVSDILSPLEESYKKVGMEGGG 63

  Fly   161 LPAPNLALIGNRTSPNAMAVRMAGPPHPPSQPPPFLAAQFQMAAA----LAHH----HQQQQQQQ 217
            |.||..|....:.:|...|::.....|..:     :.|.:.|.||    |:|.    :.......
Human    64 LGAPLAAYRQGQAAPPTAAMQQHAVGHHGA-----VTAAYHMTAAGVPQLSHSAVGGYCNGNLGN 123

  Fly   218 QQQLPPV-------PTGPPHGPHPHLPPGQIPLGIFPGGPHPGHP-------PPHGHH-----PF 263
            ..:|||.       .:||               |.:...|.|..|       |..|.:     ..
Human   124 MSELPPYQDTMRNSASGP---------------GWYGANPDPRFPAISRFMGPASGMNMSGMGGL 173

  Fly   264 GSAPHLIRDSYPLYPWLLSRHGRIFPRFPGNFLFQPFRKPKRVRTAFSPTQLLKLEHAFEGNHYV 328
            ||...:.::..||            |..|        |:.:||  .||..|:.:||..|:...|:
Human   174 GSLGDVSKNMAPL------------PSAP--------RRKRRV--LFSQAQVYELERRFKQQKYL 216

  Fly   329 VGAERKQLAQGLSLTETQVKVWFQNRRTKHKRMQQEGGDGSDTKSNKGSSSGGGGGGDGEDDAKH 393
            ...||:.||..:.||.||||:||||.|.|.||..::  ..:..:..:.|..||||||.|
Human   217 SAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKD--KAAQQQLQQDSGGGGGGGGTG------ 273

  Fly   394 DGSQHSYEDAEDPEDEDEIEEDDEDEVI-----DMDDYGSEMDAEEHQRLREQFQQQLAQHQQQF 453
                       .|:.:...::......:     |.....:...|.....|:...||| ||||.|.
Human   274 -----------CPQQQQAQQQSPRRVAVPVLVKDGKPCQAGAPAPGAASLQGHAQQQ-AQHQAQA 326

  Fly   454 MQQNAGEAATLSPQQQHQLLQQHQQHL--------QQQHHQQQQHFIQQQ 495
            .|   ..||.:|.......|..|..|.        ...||......:|.|
Human   327 AQ---AAAAAISVGSGGAGLGAHPGHQPGSAGQSPDLAHHAASPAALQGQ 373

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	25/55 (45%)
NKX2-1	NP_001073136.1	Homeodomain	192..248	CDD:459649	25/57 (44%)