Protein Alignment E5 and Nkx1-1

DIOPT Version :10

• Sequence 1: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_035450.1
• Gene: Nkx1-1 / 672284
• MGIID: 109346
• Length: 440
• Species: Mus musculus
• Alignment Length: 417
• Identity: 108/417 - (25%)
• Similarity: 152/417 - (36%)
• Gaps: 126/417 - (30%)

  Fly     5 GRQTFNMLPMAPTSPFVSSSSSVAASSTSVSASSTVSASASSKP--KLAFSIDSIVGESSTRSAP 67
            ||....:.|.|...|       :|||.|..:......|:..:.|  ..:||:..|:..:...|..
Mouse    41 GRAELPIFPRAGVPP-------LAASDTVPAVPEGAGAARPAAPPRPTSFSVLDILDPNKFNSRR 98

  Fly    68 LRVSVISSPPPRSESPASP---TNTNNSGRRTPRGYIYCRRRDSLDRSRSPQRSPVSRSPSPPNA 129
            .|..::....|.:.:|.:|   .....:..|:||.        .|:|......:.|:.:     |
Mouse    99 RRCVLLGPVVPATCAPCAPAACVAVPAASGRSPRA--------ELERRALSAATGVAAA-----A 150

  Fly   130 GGNPAAAGNT-----AKSGDPSSGTGNPPTLIRPLPLP-------APNLALIGNRTSP----NAM 178
            |..|.:||::     |::...|||:|..||.......|       ||.:........|    ..:
Mouse   151 GAEPTSAGDSYRADEAEANGYSSGSGRSPTADSEDEAPEDEDEEEAPEVQDAQGTEEPRGGSGGL 215

  Fly   179 AVRMAGPPHPPSQPPPFLAAQFQMAAALAHHHQQQQQQQQQQLPPVPTGPPHGPHPHLPPGQIPL 243
            ..|.:|.|.         ||:.:.:                   ||......||.
Mouse   216 GARGSGCPG---------AAEVEAS-------------------PVDDTAAPGPR---------- 242

  Fly   244 GIFPGGPHPGHPPP---------HGHHPFGSA----PHLIRDSYPLYPWLLSRHGRIFPRFPGNF 295
                 |..||.|.|         .|..|.|:|    |...|....      |:.|
Mouse   243 -----GNSPGAPGPPATATGAGSAGSTPQGAAVTTKPKRKRTGSD------SKSG---------- 286

  Fly   296 LFQPFRKPKRVRTAFSPTQLLKLEHAFEGNHYVVGAERKQLAQGLSLTETQVKVWFQNRRTKHKR 360
                  ||:|.||||:..||:.||:.|:...|:...||..||..|||||||||:||||||||.|:
Mouse   287 ------KPRRARTAFTYEQLVALENKFKATRYLSVCERLNLALSLSLTETQVKIWFQNRRTKWKK 345

  Fly   361 MQQEGGDGSDTKSNKGSSSGGGGGGDG 387
            .    ..|:||.:..|   ||||.|.|
Mouse   346 Q----NPGADTSAPTG---GGGGPGPG 365

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	32/55 (58%)
Nkx1-1	NP_035450.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..82		11/47 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	145..291		41/215 (19%)
		Homeodomain	289..345	CDD:459649	32/55 (58%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	342..387		12/31 (39%)