Protein Alignment E5 and ALX4

DIOPT Version :10

• Sequence 1: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_068745.2
• Gene: ALX4 / 60529
• HGNCID: 450
• Length: 411
• Species: Homo sapiens
• Alignment Length: 319
• Identity: 88/319 - (27%)
• Similarity: 112/319 - (35%)
• Gaps: 106/319 - (33%)

  Fly   102 YCRRRDSLDRSRSPQRSPVSRS---PSPPNA--GGNP------AAAGNTAKSGDPSS----GTGN 151
            ||   :|...:.....||||:|   .||..|  ||:.      :||......||..|    |.|.
Human     9 YC---ESPAAAMDAYYSPVSQSREGSSPFRAFPGGDKFGTTFLSAAAKAQGFGDAKSRARYGAGQ 70

  Fly   152 PPTLIRPLPLPAPNLALIGNRTSPNAMAVRMAGP-PHPPSQPPPFLAAQFQMAAALAHHHQQQQQ 215
             ..|..||...|      |.|.|.|....:.:.| |.||.||.|                  |||
Human    71 -QDLATPLESGA------GARGSFNKFQPQPSTPQPQPPPQPQP------------------QQQ 110

  Fly   216 QQQQQLPPVPTGPPHGPHPHLPPGQIPLGIFPGGPHPGHPPPHGHHPF--GSAPHLIRDSYPLYP 278
            |.|.|       ||..||.:|..|..            ..||.|....  ||:.|......|.|
Human   111 QPQPQ-------PPAQPHLYLQRGAC------------KTPPDGSLKLQEGSSGHSAALQVPCY- 155

  Fly   279 WLLSRHGRI-FPRFP---------------------------GNFLFQPFR---------KPKRV 306
               ::...: .|..|                           .:.|..|..         |.:|.
Human   156 ---AKESSLGEPELPPDSDTVGMDSSYLSVKEAGVKGPQDRASSDLPSPLEKADSESNKGKKRRN 217

  Fly   307 RTAFSPTQLLKLEHAFEGNHYVVGAERKQLAQGLSLTETQVKVWFQNRRTKHKRMQQEG 365
            ||.|:..||.:||..|:..||.....|:|||....|||.:|:|||||||.|.::.::.|
Human   218 RTTFTSYQLEELEKVFQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRERFG 276

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	27/55 (49%)
ALX4	NP_068745.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	75..145		31/112 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	184..219		4/34 (12%)
		Homeodomain	215..271	CDD:459649	27/55 (49%)
		OAR	387..405	CDD:461067
		OAR. /evidence=ECO:0000255|PROSITE-ProRule:PRU00138	391..404