DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment E5 and Noto

DIOPT Version :9

Sequence 1:NP_524825.1 Gene:E5 / 45396 FlyBaseID:FBgn0008646 Length:524 Species:Drosophila melanogaster
Sequence 2:NP_001007473.1 Gene:Noto / 384452 MGIID:3053002 Length:240 Species:Mus musculus


Alignment Length:185 Identity:58/185 - (31%)
Similarity:75/185 - (40%) Gaps:57/185 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly   238 PGQIPLGIFP-----------------GGPHPGHPPPHGHHPFGSAPHL-IRDSYPLYPWLLSRH 284
            |..:.:|::|                 |....|...|:...|...||.: :||           |
Mouse    90 PAYLSVGVYPLCSMSCVPGLNVTHHQQGLRLTGSELPYCLGPLKWAPTVDLRD-----------H 143

  Fly   285 GRIFPRFPGNFLFQPFRKPKRVRTAFSPTQLLKLEHAFEGNHYVVGAERKQLAQGLSLTETQVKV 349
            |             ..|..|||||.|:..||.:||..|...|.:||.||.|||..|.|||.||::
Mouse   144 G-------------TERHTKRVRTTFNLQQLQELEKVFAKQHNLVGKERAQLAARLHLTENQVRI 195

  Fly   350 WFQNRRTKHKRMQQEGGDGSDTKSNKGSSSGGGGGGDGEDDAKHDGSQHSYEDAE 404
            ||||||.|:::.|:.....|.......|||              ||:..| ||||
Mouse   196 WFQNRRVKYQKQQKLKLPSSSVMEEPSSSS--------------DGNIQS-EDAE 235

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
E5NP_524825.1 Homeobox 307..359 CDD:278475 29/51 (57%)
NotoNP_001007473.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..21
Homeobox 153..204 CDD:278475 28/50 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 208..240 12/43 (28%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0850
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR24339
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
43.910

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