DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E5 and NOTO

DIOPT Version :9

Sequence 1:	NP_524825.1	Gene:	E5 / 45396	FlyBaseID:	FBgn0008646	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001127934.1	Gene:	NOTO / 344022	HGNCID:	31839	Length:	251	Species:	Homo sapiens

Alignment Length:	293	Identity:	86/293 - (29%)
Similarity:	111/293 - (37%)	Gaps:	83/293 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    75 SPPPRSESPASPTNTNNSGRRTPRGYIYCRRRDSLDRSRSPQ--RSPVSRSPSPPNAGGNPAAAG 137
            ||.||...|.:|:.:                     |.|.|:  |||..|||:.||   .|.|.|
Human     3 SPRPRGSPPPAPSGS---------------------RVRPPRSGRSPAPRSPTGPN---TPRAPG 43

  Fly   138 NTAKSGDPSSGTGNPPTLIRPLP-LPAPNLALIGNRTSPNAMAVRMAGPPHPPSQPPPFLAAQFQ 201
               :...|.|...   .|.||.| .||        .:.|:..|.     .||          .|.
Human    44 ---RFESPFSVEA---ILARPDPCAPA--------ASQPSGSAC-----VHP----------AFW 79

  Fly   202 MAAALAHHHQQQQQQQQQQLPPVPTGPPHGPHPHLPPGQIPLGIFPGGPHPGHPPPHGHHPFGSA 266
            .||:|.                ...|.|........|..:.:|.:| .|.|...|..|...||..
Human    80 TAASLC----------------ATGGLPWACPTSWLPAYLSVGFYP-VPGPRVAPVCGLLGFGVT 127

  Fly   267 PHLIRDSYPLYPWLLSRHGRIFPRF-PGNFLFQPFRKPKRVRTAFSPTQLLKLEHAFEGNHYVVG 330
            ...:.....|:         .||.: |...|....|:.|||||.|:..||.:||..|...|.:||
Human   128 GLELAHCSGLW---------AFPDWAPTEDLQDTERQQKRVRTMFNLEQLEELEKVFAKQHNLVG 183

  Fly   331 AERKQLAQGLSLTETQVKVWFQNRRTKHKRMQQ 363
            .:|.|||..|.|||.||:|||||||.|:::.|:
Human   184 KKRAQLAARLKLTENQVRVWFQNRRVKYQKQQK 216

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeobox	307..359	CDD:278475	29/51 (57%)
NOTO	NP_001127934.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..47		20/70 (29%)
		Homeobox	160..211	CDD:278475	28/50 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	224..251
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24339
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910