Protein Alignment E5 and HOXC12

DIOPT Version :10

• Sequence 1: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_776272.1
• Gene: HOXC12 / 3228
• HGNCID: 5124
• Length: 282
• Species: Homo sapiens
• Alignment Length: 332
• Identity: 75/332 - (22%)
• Similarity: 108/332 - (32%)
• Gaps: 137/332 - (41%)

  Fly    65 SAPLRVSVISSPPPRSESPASPTNTNNSGRRTPRGYIYCRRRDSLDRSRSPQ---RSPVSRSP-- 124
            |.|.|.:|.|...|.:|    |.|          ||              ||   .||||.:|
Human    43 SYPRRDNVCSLSWPSAE----PCN----------GY--------------PQPYLGSPVSLNPPF 79

  Fly   125 ----------------SPPNAGGNPAAAGNTAKSGDPSSGTGNPPTLIRPLPLPAPNLALIGNRT 173
                            ..|.|.|.........:..||.:|.|.....:.|              :
Human    80 GRTCELARVEDGKGYYREPCAEGGGGGLKREERGRDPGAGPGAALLPLEP--------------S 130

  Fly   174 SPNAMAVRM--------------AGPPHPPSQPPPFLAAQFQMAAALAHHHQQQQQQQQQQLPPV 224
            .|.|:..:.              |||||   .||...:.:...:::|.:...:
Human   131 GPPALGFKYDYAAGGGGGDGGGGAGPPH---DPPSCQSLESDSSSSLLNEGNK------------ 180

  Fly   225 PTGPPHGPHPHLPPGQIPLGIFPGGPHPGHPPPHGHHPFGSAPHLIRDSYPLYPWLLSRHGRIFP 289
              |...|     .||.:...:.|||         |....|:            ||
Human   181 --GAGAG-----DPGSLVSPLNPGG---------GLSASGA------------PW---------- 207

  Fly   290 RFPGNFLFQPFRKPKRVRTAFSPTQLLKLEHAFEGNHYVVGAERKQLAQGLSLTETQVKVWFQNR 354
             :|.|...:..|||      :|..||.:||..|..|.::....|::|:..|:|::.|||:|||||
Human   208 -YPINSRSRKKRKP------YSKLQLAELEGEFLVNEFITRQRRRELSDRLNLSDQQVKIWFQNR 265

  Fly   355 RTKHKRM 361
            |.|.||:
Human   266 RMKKKRL 272

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	21/55 (38%)
HOXC12	NP_776272.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	94..129		7/34 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	147..214		21/120 (18%)
		Homeodomain	215..271	CDD:459649	24/61 (39%)