Protein Alignment E5 and HOXC4

DIOPT Version :10

• Sequence 1: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_055435.2
• Gene: HOXC4 / 3221
• HGNCID: 5126
• Length: 264
• Species: Homo sapiens
• Alignment Length: 260
• Identity: 70/260 - (26%)
• Similarity: 99/260 - (38%)
• Gaps: 59/260 - (22%)

  Fly   185 PPHPPSQPPPFLAAQFQMAAALAHHHQQQQQQQQQQLPPVPTGPP----------------HGP- 232
            |.|.|........:.||      ||||:.....    ||.|:.|.                |||
Human    30 PEHSPEYYGRTRESGFQ------HHHQELYPPP----PPRPSYPERQYSCTSLQGPGNSRGHGPA 84

  Fly   233 ---HPHLPPGQ-----IPLGIFPGGPHPGHP---PPHGHHPFGSAPHLIRDSYPL-YPWLLSRH- 284
               |.|....|     .||......|.|..|   .|...||..:|     ...|: |||:...|
Human    85 QAGHHHPEKSQSLCEPAPLSGASASPSPAPPACSQPAPDHPSSAA-----SKQPIVYPWMKKIHV 144

  Fly   285 GRIFPRFPGNFLFQPFRKPKRVRTAFSPTQLLKLEHAFEGNHYVVGAERKQLAQGLSLTETQVKV 349
            ..:.|.:.|.       :|||.|||::..|:|:||..|..|.|:....|.::|..|.|:|.|:|:
Human   145 STVNPNYNGG-------EPKRSRTAYTRQQVLELEKEFHYNRYLTRRRRIEIAHSLCLSERQIKI 202

  Fly   350 WFQNRRTKHKRMQQEGGDGSDTKSNKGSSSGGGGGGDGEDDAKHDGSQHSYEDAEDPEDEDEIEE 414
            ||||||.|.|:..:       ..:.|..|:...|.......|...|:...:..:..|.::...|:
Human   203 WFQNRRMKWKKDHR-------LPNTKVRSAPPAGAAPSTLSAATPGTSEDHSQSATPPEQQRAED 260

  Fly   415  414
            Human   261  260

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	26/55 (47%)
HOXC4	NP_055435.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..130		28/114 (25%)
		Antp-type hexapeptide	135..140		3/4 (75%)
		Homeodomain	157..213	CDD:459649	26/55 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	214..264		7/54 (13%)