Protein Alignment E5 and HOXA10

DIOPT Version :10

• Sequence 1: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_061824.3
• Gene: HOXA10 / 3206
• HGNCID: 5100
• Length: 410
• Species: Homo sapiens
• Alignment Length: 350
• Identity: 77/350 - (22%)
• Similarity: 106/350 - (30%)
• Gaps: 146/350 - (41%)

  Fly   127 PNAGG------NPAAAGNTAKSGDPSSGTGNPPTLIRPLPLPAPNLALIGNRTSPNAMAVRMA-- 183
            |..||      :|.:.|.....|..:.|.|..|.   .|.|.||.             :.||.
Human    82 PTLGGKRNEAASPGSGGGGGGLGPGAHGYGPSPI---DLWLDAPR-------------SCRMEPP 130

  Fly   184 -GPPHPPSQ--PPPFLAAQFQMAAALAHHHQQQQQQQQ-----------------QQLPPVPTGP 228
             |||.||.|  |||....|....|......|..:::..                 .:|.|.|.||
Human   131 DGPPPPPQQQPPPPPQPPQPAPQATSCSFAQNIKEESSYCLYDSADKCPKVSATAAELAPFPRGP 195

  Fly   229 P-----------------------------------------HGPHPHLPPGQ---IPLGIFPGG 249
            |                                         .||.|..|||:   :|..:..|.
Human   196 PPDGCALGTSSGVPVPGYFRLSQAYGTAKGYGSGGGGAQQLGAGPFPAQPPGRGFDLPPALASGS 260

  Fly   250 PHPGH--------PPP--------------HGHHPFGSAPHLI---RDSYPLYP----------- 278
            .....        |||              ..|....:|..|.   .:|....|
Human   261 ADAARKERALDSPPPPTLACGSGGGSQGDEEAHASSSAAEELSPAPSESSKASPEKDSLGNSKGE 325

  Fly   279 ----WLLSRHGRIFPRFPGNFLFQPFRKPKRVRTAFSPTQLLKLEHAFEGNHYVVGAERKQLAQG 339
                ||.::.||                  :.|..::..|.|:||..|..|.|:....|.::::.
Human   326 NAANWLTAKSGR------------------KKRCPYTKHQTLELEKEFLFNMYLTRERRLEISRS 372

  Fly   340 LSLTETQVKVWFQNRRTKHKRMQQE 364
            :.||:.|||:||||||.|.|:|.:|
Human   373 VHLTDRQVKIWFQNRRMKLKKMNRE 397

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	21/55 (38%)
HOXA10	NP_061824.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	89..158		23/84 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	221..339		20/135 (15%)
		Homeodomain	337..393	CDD:459649	22/73 (30%)