Protein Alignment E5 and HLX

DIOPT Version :10

• Sequence 1: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_068777.1
• Gene: HLX / 3142
• HGNCID: 4978
• Length: 488
• Species: Homo sapiens
• Alignment Length: 373
• Identity: 99/373 - (26%)
• Similarity: 128/373 - (34%)
• Gaps: 120/373 - (32%)

  Fly   125 SPPNAGGNPAAA-----GNTAKSGDPSSGTGNPPTLIRPLPLPAPNLALIG--NRTSPNAMAVRM 182
            :|....|..|||     |:........:...:|   :||.|:.||:....|  .|.||
Human    60 APEGLAGASAAALTAHLGSVHPHASFQAAARSP---LRPTPVVAPSEVPAGFPQRLSP------- 114

  Fly   183 AGPPHPPSQPPPFLAAQFQMAAALAHHH----QQQQQQQQQQLPPVPTG----PPHG-----PHP 234
                               ::||..|||    |||||.||||.||.|..    ||..     |:|
Human   115 -------------------LSAAYHHHHPQQQQQQQQPQQQQPPPPPRAGALQPPASGTRVVPNP 160

  Fly   235 H----------------------------------------LPPGQIPLGIFPGGPHPG------ 253
            |                                        |..|..|.|:...|..|.
Human   161 HHSGSAPAPSSKDLKFGIDRILSAEFDPKVKEGNTLRDLTSLLTGGRPAGVHLSGLQPSAGQFFA 225

  Fly   254 --HP--------PPHGHHPFGSAPHLIRDSYPLYPWLLSRHGRIFPRFPGNFLFQPFRKPKRVRT 308
              .|        .|...:|..|..|..:|::|....:|::     ...|..:.    ||....|.
Human   226 SLDPINEASAILSPLNSNPRNSVQHQFQDTFPGPYAVLTK-----DTMPQTYK----RKRSWSRA 281

  Fly   309 AFSPTQLLKLEHAFEGNHYVVGAERKQLAQGLSLTETQVKVWFQNRRTKHKRMQQEGGDGSDTKS 373
            .||..|...||..||...||...:|||||..|.||:.||||||||||.|.:..::........|.
Human   282 VFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKDKE 346

  Fly   374 NKGSSSGGGGGGDGEDD----AKHDGSQHSYEDAEDPEDEDEIEEDDE 417
            .....|||....|||.|    ::.:|...|  ::.|.|..|....|.|
Human   347 AGEKPSGGAPAADGEQDERSPSRSEGEAES--ESSDSESLDMAPSDTE 392

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	29/55 (53%)
HLX	NP_068777.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	118..173		21/54 (39%)
		Homeodomain	273..333	CDD:459649	31/63 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	331..488		15/64 (23%)