DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E5 and dlx3b

DIOPT Version :9

Sequence 1:	NP_524825.1	Gene:	E5 / 45396	FlyBaseID:	FBgn0008646	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_571397.2	Gene:	dlx3b / 30585	ZFINID:	ZDB-GENE-980526-280	Length:	269	Species:	Danio rerio

Alignment Length:	187	Identity:	54/187 - (28%)
Similarity:	78/187 - (41%)	Gaps:	31/187 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 HPPSQPPPFL--AAQFQMAAALAHHHQQQQQQQQQQLPPVPTGPPHGPHPHLPPGQIPLGIFPGG 249
            ||.|:..|.|  ::...|....:||...|.....||:        :..|.....|.        |
Zfish    24 HPTSKDSPTLPESSATDMGYYSSHHEYYQSPPYPQQM--------NSYHQFNLSGM--------G 72

  Fly   250 PHPGHPPPHGHHPFGS---APHLIRDSYPLYPWLLSRHGRIFPRFPGNFLFQPFRKPKRV---RT 308
            ..||..|....:|:.:   ..|..||       |.:.........|...:.....|||::   ||
Zfish    73 ATPGAYPTKTEYPYNTYRQYGHYNRD-------LQTPPQSAVKEEPETEVRMVNGKPKKIRKPRT 130

  Fly   309 AFSPTQLLKLEHAFEGNHYVVGAERKQLAQGLSLTETQVKVWFQNRRTKHKRMQQEG 365
            .:|..||..|:..|:...|:...||.:||..|.||:||||:||||||:|.|::.:.|
Zfish   131 IYSSYQLAALQRRFQKAQYLALPERAELAAQLGLTQTQVKIWFQNRRSKFKKLYKNG 187

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeobox	307..359	CDD:278475	26/51 (51%)
dlx3b	NP_571397.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..41		5/16 (31%)
		DLL_N	28..104	CDD:289198	19/98 (19%)
		Homeobox	128..181	CDD:278475	26/52 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..242
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	250..269
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810