Protein Alignment E5 and TLX3

DIOPT Version :10

• Sequence 1: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_066305.2
• Gene: TLX3 / 30012
• HGNCID: 13532
• Length: 291
• Species: Homo sapiens
• Alignment Length: 271
• Identity: 71/271 - (26%)
• Similarity: 97/271 - (35%)
• Gaps: 83/271 - (30%)

  Fly   203 AAALAHHHQ-------QQQQQQQQQLPPVPTGP-------------PHGPHPHLPPG-------- 239
            :|...|.|:       |......|...|.|.||             |...:|.||..
Human     6 SAQTPHPHEPISFGIDQILNSPDQDSAPAPRGPDGASYLGGPPGGRPGATYPSLPASFAGLGAPF 70

  Fly   240 ------QIPLGIFPGG--------PHPGHPPPHGHHPFGSA-PHLIRDSYPL--------YPWLL 281
                  .:.|.:.|.|        |.||..||    |..|| |.:  .|.|.        :||:.
Human    71 EDAGSYSVNLSLAPAGVIRVPAHRPLPGAVPP----PLPSALPAM--PSVPTVSSLGGLNFPWME 129

  Fly   282 SRHGRIFPRFPGNFLFQPFR---------------KPKRVRTAFSPTQLLKLEHAFEGNHYVVGA 331
            |....:..||.......||.               |.|:.||:||..|:.:||..|....|:..|
Human   130 SSRRFVKDRFTAAAALTPFTVTRRIGHPYQNRTPPKRKKPRTSFSRVQICELEKRFHRQKYLASA 194

  Fly   332 ERKQLAQGLSLTETQVKVWFQNRRTKHKRMQQEGGDGSDTKSNKGSSSGGGGGGDGEDDAKHDGS 396
            ||..||:.|.:|:.|||.||||||||.:|...|..:....::::...           ..:||..
Human   195 ERAALAKSLKMTDAQVKTWFQNRRTKWRRQTAEEREAERQQASRLML-----------QLQHDAF 248

  Fly   397 QHSYEDAEDPE 407
            |.|..|:..|:
Human   249 QKSLNDSIQPD 259

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	28/55 (51%)
TLX3	NP_066305.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56		10/49 (20%)
		Homeodomain	167..223	CDD:459649	28/55 (51%)