Protein Alignment E5 and NKX2-8

DIOPT Version :10

• Sequence 1: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_055175.2
• Gene: NKX2-8 / 26257
• HGNCID: 16364
• Length: 239
• Species: Homo sapiens
• Alignment Length: 189
• Identity: 57/189 - (30%)
• Similarity: 71/189 - (37%)
• Gaps: 49/189 - (25%)

  Fly   229 PHGPHPHLPPGQIPLGIFPGGPHPGHPPP----------HGHHPFGSAPHLIRDSYPLYPWLLSR 283
            |.....|||..:         |.|..|.|          .||:|...     ..|....|...|:
Human    18 PEQDAQHLPRRE---------PEPRAPQPDPCAAWLDSERGHYPSSD-----ESSLETSPPDSSQ 68

  Fly   284 HGRIFPRFPGNFLFQPFRKPKRVRTAFSPTQLLKLEHAFEGNHYVVGAERKQLAQGLSLTETQVK 348
            .....|..||:    ...|.|:.|..||..|.|:||..|....|:...||:|||..|.||.||||
Human    69 RPSARPASPGS----DAEKRKKRRVLFSKAQTLELERRFRQQRYLSAPEREQLASLLRLTPTQVK 129

  Fly   349 VWFQNRRTKHKRMQQEG-GDGSDTKSN--------------------KGSSSGGGGGGD 386
            :||||.|.|.||.:..| .:..|..::                    .|...||||||:
Human   130 IWFQNHRYKLKRARAPGAAESPDLAASAELHAAPGLLRRVVVPVLVRDGQPCGGGGGGE 188

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	28/55 (51%)
NKX2-8	NP_055175.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..87		19/86 (22%)
		Homeodomain	85..141	CDD:459649	28/55 (51%)