DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E5 and EMX2

DIOPT Version :9

Sequence 1:	NP_524825.1	Gene:	E5 / 45396	FlyBaseID:	FBgn0008646	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_004089.1	Gene:	EMX2 / 2018	HGNCID:	3341	Length:	252	Species:	Homo sapiens

Alignment Length:	340	Identity:	120/340 - (35%)
Similarity:	141/340 - (41%)	Gaps:	127/340 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    48 PKLAFSIDSIVGESSTRSAPLRVSVISSPPPRSESPASPTNTNNSGRRTPRGYIYCRRRDSLDRS 112
            ||..|:|:|:|.:.|    ||       |..|||.|..|.                    :|..:
Human     6 PKRCFTIESLVAKDS----PL-------PASRSEDPIRPA--------------------ALSYA 39

  Fly   113 RSPQRSPVSRSPSPPNAGGNPAAAGNTAKSGDPSSGTGNPPTLIRPLPLPAPNLALIGNRTSPNA 177
            .|        ||..|...|..:||...|..|..|    ||..:........||.|:
Human    40 NS--------SPINPFLNGFHSAAAAAAGRGVYS----NPDLVFAEAVSHPPNPAV--------- 83

  Fly   178 MAVRMAGPPHPPSQPPPFLAAQFQMAAALAHHHQQQQQQQQQQLPPVPTGPPHGPHPHLPPGQIP 242
                   |.||  .|||.         |||.|             |:|:.  |.|||.....|
Human    84 -------PVHP--VPPPH---------ALAAH-------------PLPSS--HSPHPLFASQQ-- 113

  Fly   243 LGIFPGGPHPGHPPPHGHHPFGSAPHLIRDSYPLYPWLLSRHGRIFPRFPGN------FLFQP-- 299
                                        ||....||||:.|:..:..||.||      ||...
Human   114 ----------------------------RDPSTFYPWLIHRYRYLGHRFQGNDTSPESFLLHNAL 150

  Fly   300 FRKPKRVRTAFSPTQLLKLEHAFEGNHYVVGAERKQLAQGLSLTETQVKVWFQNRRTKHKR--MQ 362
            .|||||:||||||:|||:||||||.|||||||||||||..||||||||||||||||||.||  ::
Human   151 ARKPKRIRTAFSPSQLLRLEHAFEKNHYVVGAERKQLAHSLSLTETQVKVWFQNRRTKFKRQKLE 215

  Fly   363 QEGGDGSDTKSNKGS 377
            :||.|....|  ||:
Human   216 EEGSDSQQKK--KGT 228

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeobox	307..359	CDD:278475	46/51 (90%)
EMX2	NP_004089.1	Homeobox	158..211	CDD:395001	46/52 (88%)
EMX2	NP_004089.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..252		6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	104	1.000	Domainoid score	I6707
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	158	1.000	Inparanoid score	I4276
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000921
OrthoInspector	1	1.000	-	-		mtm8552
orthoMCL	1	0.900	-	-		OOG6_109182
Panther	1	1.100	-	-	O	PTHR24339
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3162
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	10	9.890