Protein Alignment E5 and Nkx6-1

DIOPT Version :9

• Sequence 1: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_659204.1
• Gene: Nkx6-1 / 18096
• MGIID: 1206039
• Length: 365
• Species: Mus musculus
• Alignment Length: 447
• Identity: 115/447 - (25%)
• Similarity: 146/447 - (32%)
• Gaps: 148/447 - (33%)

  Fly    13 PMAPTSPFVSSSSSVAASSTSVSASSTVSASASSKPKLAFSIDSIVGESSTRSAPLRVSVISSPP 77
            |..||.|..|||||.::||.|....|  ......||..|..:.|:                 ..|
Mouse    41 PPLPTGPPSSSSSSSSSSSPSPPLGS--HNPGGLKPPAAGGLSSL-----------------GSP 86

  Fly    78 PRSESPASPTNTNNSGRRTPRGYIYCRRRDSLDRSRSPQRSPVSRSPSPPNAGGNPAAAGNTAKS 142
            |:..|.|:|...|                |.|.|            ||.|.|.|  ||..:.:.|
Mouse    87 PQQLSAATPHGIN----------------DILSR------------PSMPVASG--AALPSASPS 121

  Fly   143 GDPSSGTGNPPTLIRPLPLPAPNLALIGNRTSPNAMAVRMAGPPH----PPSQPPPFLAAQFQMA 203
            |..||.:.:...........|...|.....:||..:   :||.|.    .|..|||.|......|
Mouse   122 GSSSSSSSSASATSASAAAAAAAAAAAAAASSPAGL---LAGLPRFSSLSPPPPPPGLYFSPSAA 183

  Fly   204 AALAHHHQQQQQQQQQQLPPVPTGPPHGPHPHLPPGQIPLGIFPGGPHPGHPPPHGHHPFGSAPH 268
            |..|                  .|....|...| ||:.|: .:||   ....||.........||
Mouse   184 AVAA------------------VGRYPKPLAEL-PGRTPI-FWPG---VMQSPPWRDARLACTPH 225

  Fly   269 LIRDSYPLYPWLLSRHGRIFPRFPGNFLFQPFRKPKRVRTAFSPTQLLKLEHAFEGNHYVVGAER 333
                                   .|:.|.....|.|..|..||..|:..||..||...|:.|.||
Mouse   226 -----------------------QGSILLDKDGKRKHTRPTFSGQQIFALEKTFEQTKYLAGPER 267

  Fly   334 KQLAQGLSLTETQVKVWFQNRRTKHKRMQQEGGDGSDTKSNKGSSSGGGGGGDGEDDAKHDGSQH 398
            .:||..|.:||:||||||||||||.::                               ||.....
Mouse   268 ARLAYSLGMTESQVKVWFQNRRTKWRK-------------------------------KHAAEMA 301

  Fly   399 SYEDAEDPEDE-----DEIEEDDEDEVIDMDDYGSEMDAEEHQRLREQFQQQLAQHQ 450
            :.:..:|.|.|     .|.||||       |||...:|.....   |:..|.|.:|:
Mouse   302 TAKKKQDSETERLKGTSENEEDD-------DDYNKPLDPNSDD---EKITQLLKKHK 348

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeobox	307..359	CDD:278475	29/51 (57%)
Nkx6-1	NP_659204.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..136		37/143 (26%)
		Repressor domain. /evidence=ECO:0000250	102..269		56/229 (24%)
		Homeobox	240..293	CDD:278475	29/52 (56%)
		DUF3381	<291..345	CDD:288694	17/94 (18%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..365		18/64 (28%)
		Involved in DNA-binding. /evidence=ECO:0000250	307..365		16/52 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.810