DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E5 and DLX6

DIOPT Version :9

Sequence 1:	NP_524825.1	Gene:	E5 / 45396	FlyBaseID:	FBgn0008646	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_005213.3	Gene:	DLX6 / 1750	HGNCID:	2919	Length:	293	Species:	Homo sapiens

Alignment Length:	217	Identity:	73/217 - (33%)
Similarity:	96/217 - (44%)	Gaps:	55/217 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   211 QQQQQQQQQQLPPVPTGPPHGPH-----PHLPPGQIPL-------GIFPGGPHPGHPPPHGHH-- 261
            ||||||||||.||.|..||..||     |.:.....||       .....|.|..|...|.||
Human    34 QQQQQQQQQQQPPPPPPPPPQPHSQQSSPAMAGAHYPLHCLHSAAAAAAAGSHHHHHHQHHHHGS 98

  Fly   262 PFGSA-----PHLIRDSYPLY------PWLLSRH-----------------------GRIFPRFP 292
            |:.|.     .|....:||..      |:|.|.|                       |.|  ||.
Human    99 PYASGGGNSYNHRSLAAYPYMSHSQHSPYLQSYHNSSAAAQTRGDDTDQQKTTVIENGEI--RFN 161

  Fly   293 GNFLFQPFRKPKRVRTAFSPTQLLKLEHAFEGNHYVVGAERKQLAQGLSLTETQVKVWFQNRRTK 357
            |.  .:..|||   ||.:|..||..|.|.|:...|:...||.:||..|.||:||||:||||:|:|
Human   162 GK--GKKIRKP---RTIYSSLQLQALNHRFQQTQYLALPERAELAASLGLTQTQVKIWFQNKRSK 221

  Fly   358 HKRMQQEGGDGSDTKSNKGSSS 379
            .|::.::|.:..::...:||::
Human   222 FKKLLKQGSNPHESDPLQGSAA 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeobox	307..359	CDD:278475	26/51 (51%)
DLX6	NP_005213.3	COG5576	119..>231	CDD:227863	40/118 (34%)
DLX6	NP_005213.3	Homeobox	170..223	CDD:278475	27/55 (49%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810