DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment E5 and DLX2

DIOPT Version :9

Sequence 1:	NP_524825.1	Gene:	E5 / 45396	FlyBaseID:	FBgn0008646	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_004396.1	Gene:	DLX2 / 1746	HGNCID:	2915	Length:	328	Species:	Homo sapiens

Alignment Length:	277	Identity:	76/277 - (27%)
Similarity:	102/277 - (36%)	Gaps:	100/277 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   201 QMAAALAHHHQQQQQQQQQQLPPVPTGPPHGP---------------HPHLPPG----------- 239
            |:||:..:|..||.          |:|...||               .|.||..
Human    16 QIAASSTYHQHQQP----------PSGGGAGPGGNSSSSSSLHKPQESPTLPVSTATDSSYYTNQ 70

  Fly   240 QIPLGIFPGGPHPGHPPPH-GHHPF-----GSAPHLIRDSYPL---------YPWLLSRHGRIFP 289
            |.|.|   ||...|.|..| |.:.:     .:.|:..:.||.|         .|:..|..
Human    71 QHPAG---GGGGGGSPYAHMGSYQYQASGLNNVPYSAKSSYDLGYTAAYTSYAPYGTSSS----- 127

  Fly   290 RFPGNFLFQPFR------------KPKRV---RTAFSPTQLLKLEHAFEGNHYVVGAERKQLAQG 339
              |.|  .:|.:            |||:|   ||.:|..||..|:..|:...|:...||.:||..
Human   128 --PAN--NEPEKEDLEPEIRIVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAAS 188

  Fly   340 LSLTETQVKVWFQNRRTKHKRMQQEGGDGSDTKSNKGSS----------------------SGGG 382
            |.||:||||:||||||:|.|:|.:.|...|:......:|                      :|||
Human   189 LGLTQTQVKIWFQNRRSKFKKMWKSGEIPSEQHPGASASPPCASPPVSAPASWDFGVPQRMAGGG 253

  Fly   383 GGGDGEDDAKHDGSQHS 399
            |.|.|...|...||..|
Human   254 GPGSGGSGAGSSGSSPS 270

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeobox	307..359	CDD:278475	26/51 (51%)
DLX2	NP_004396.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	16..81		18/77 (23%)
		DLL_N	51..132	CDD:289198	20/92 (22%)
		Homeobox	155..208	CDD:278475	26/52 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	211..270		12/58 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	300..328
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810