Protein Alignment E5 and GSX2

DIOPT Version :10

• Sequence 1: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_573574.2
• Gene: GSX2 / 170825
• HGNCID: 24959
• Length: 304
• Species: Homo sapiens
• Alignment Length: 402
• Identity: 101/402 - (25%)
• Similarity: 135/402 - (33%)
• Gaps: 136/402 - (33%)

  Fly    51 AFSIDSIVGESSTRSAPLRVSV------------ISSPPPRSESPASPTNTNNSGRRTPRGYIYC 103
            :|.:||::.:.::|.||   |:            :..|||...|.:.|.               |
Human     4 SFYVDSLIIKDTSRPAP---SLPEPHPGPDFFIPLGMPPPLVMSVSGPG---------------C 50

  Fly   104 RRRDSLDRSRSP--QRSPVSRSPSPPNAGGNPAAAGNTAKSGDPSSGTGNPPTLIRPLPLPAPNL 166
            ..|.|......|  ..|.:..|.....||...|.||.|...|...:|......|::.....||.
Human    51 PSRKSGAFCVCPLCVTSHLHSSRGSVGAGSGGAGAGVTGAGGSGVAGAAGALPLLKGQFSSAPG- 114

  Fly   167 ALIGNRTSPNAMAVRMAGPPHPPSQPPPFLAAQFQMAAALAHHHQQQQQQQQQQLPPVPTGPPHG 231
                                          .|||......||||..               ||..
Human   115 ------------------------------DAQFCPRVNHAHHHHH---------------PPQH 134

  Fly   232 PHPHLPPGQIPLGIFPGGPHP--------------GHPPPHGHHPFGSAPHLIRDSY----PLYP 278
            .|.|..|.|      ||....              |||.   ||    ||.....:|    |...
Human   135 HHHHHQPQQ------PGSAAAAAAAAAAAAAAAALGHPQ---HH----APVCTATTYNVADPRRF 186

  Fly   279 WLLSRHGRIFPRFPGNFLFQPFRKPKRVRTAFSPTQLLKLEHAFEGNHYVVGAERKQLAQGLSLT 343
            ..|:..|....:.|..         ||:||||:.||||:||..|..|.|:....|.::|..|:|:
Human   187 HCLTMGGSDASQVPNG---------KRMRTAFTSTQLLELEREFSSNMYLSRLRRIEIATYLNLS 242

  Fly   344 ETQVKVWFQNRRTKHKRMQQEGGDGSDTKSNKGSSSGGGGGGDGEDDAKHDGSQHSYEDAEDPED 408
            |.|||:||||||.|||:    .|.|:...|:.|              .|..|||..|..:||.:.
Human   243 EKQVKIWFQNRRVKHKK----EGKGTQRNSHAG--------------CKCVGSQVHYARSEDEDS 289

  Fly   409 EDEIEEDDEDEV 420
            ......:|:.|:
Human   290 LSPASANDDKEI 301

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	31/55 (56%)
GSX2	NP_573574.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	116..151		15/55 (27%)
		Homeodomain	203..259	CDD:459649	31/55 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	283..304		4/19 (21%)