DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E5 and NKX6-3

DIOPT Version :9

Sequence 1:	NP_524825.1	Gene:	E5 / 45396	FlyBaseID:	FBgn0008646	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_001351770.1	Gene:	NKX6-3 / 157848	HGNCID:	26328	Length:	265	Species:	Homo sapiens

Alignment Length:	247	Identity:	74/247 - (29%)
Similarity:	96/247 - (38%)	Gaps:	54/247 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 AQF-QMAAALAHHHQQQQQQQQQQLPPVPTGP------PHG-----PHPHLPPGQIPLGIFPGGP 250
            ||| :|.|.:.   |...|....:|.|...||      |||     ..|...|..   .:..|.|
Human    17 AQFPEMKAPVC---QYSVQNSFYKLSPPGLGPQLAAGTPHGITDILSRPVAAPNN---SLLSGYP 75

  Fly   251 HPG-----------HPPPHGHHPFGSAPHLIRDSYPL----------YPWLLSRHGRIFPRFPGN 294
            |..           :.|..|:  |..|    .:.||.          ..|   |.||.....| :
Human    76 HVAGFGGLSSQGVYYSPQVGN--FSKA----GNEYPTRTRNCWADTGQDW---RGGRQCSNTP-D 130

  Fly   295 FLFQPFRKPKRVRTAFSPTQLLKLEHAFEGNHYVVGAERKQLAQGLSLTETQVKVWFQNRRTKHK 359
            .|.....|.|..|..|:..|:..||..||...|:.|.||.:||..|.:||:||||||||||||.:
Human   131 PLSDSIHKKKHTRPTFTGHQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWR 195

  Fly   360 RMQQEGGDGSDTKSNKGSSSGGGGGGDGEDDAKHDGSQHSYEDAEDPEDEDE 411
            :.     ...:..|:...:.||.|.|.|.|.|..:.....|....||:.:||
Human   196 KK-----SALEPSSSTPRAPGGAGAGAGGDRAPSENEDDEYNKPLDPDSDDE 242

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeobox	307..359	CDD:278475	28/51 (55%)
NKX6-3	NP_001351770.1	Homeobox	142..195	CDD:306543	28/52 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810