DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E5 and Dlx5

DIOPT Version :9

Sequence 1:	NP_524825.1	Gene:	E5 / 45396	FlyBaseID:	FBgn0008646	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_034186.2	Gene:	Dlx5 / 13395	MGIID:	101926	Length:	289	Species:	Mus musculus

Alignment Length:	190	Identity:	59/190 - (31%)
Similarity:	85/190 - (44%)	Gaps:	31/190 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 AQFQMAAALAHHHQQQQQQQQQQLPPVPTGPPHGPHPHLPPGQIPLG-IFPGGPHPG---HPPPH 258
            |.|..:||:  ||..|:.      |.:|.........:.|.|..|.| ..|.....|   :|..:
Mouse    19 APFPTSAAM--HHPSQES------PTLPESSATDSDYYSPAGAAPHGYCSPTSASYGKALNPYQY 75

  Fly   259 GHHPF-GSAPHLIRDSYPLYPWLLSRH--GRIFPRFPGNFLFQPFR------------KPKRV-- 306
            .:|.. |||......:|..|.:....|  |..:.|.| :...||.:            |||:|
Mouse    76 QYHGVNGSAAGYPAKAYADYGYASPYHQYGGAYNRVP-SATSQPEKEVAEPEVRMVNGKPKKVRK 139

  Fly   307 -RTAFSPTQLLKLEHAFEGNHYVVGAERKQLAQGLSLTETQVKVWFQNRRTKHKRMQQEG 365
             ||.:|..||..|:..|:...|:...||.:||..|.||:||||:||||:|:|.|::.:.|
Mouse   140 PRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQNKRSKIKKIMKNG 199

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeobox	307..359	CDD:278475	25/51 (49%)
Dlx5	NP_034186.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..49		9/37 (24%)
		DLL_N	32..118	CDD:403572	20/92 (22%)
		Homeobox	140..194	CDD:395001	25/53 (47%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	198..253		1/2 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	270..289
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810