DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment E5 and Cdx1

DIOPT Version :9

Sequence 1:	NP_524825.1	Gene:	E5 / 45396	FlyBaseID:	FBgn0008646	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_034010.3	Gene:	Cdx1 / 12590	MGIID:	88360	Length:	268	Species:	Mus musculus

Alignment Length:	317	Identity:	90/317 - (28%)
Similarity:	108/317 - (34%)	Gaps:	123/317 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    99 GYIYCRRRDSLDRSRSPQRSPVSRSPSPPNAGGNPAAAGNTAKSGDPSSGTGNPPTLIRPLPLPA 163
            ||:       ||:.     |||...|:.|:                 |.|.| |||...|.|.||
Mouse     4 GYV-------LDKD-----SPVYPGPARPS-----------------SLGLG-PPTYAPPGPAPA 38

  Fly   164 PNLALIGNRTSPNAMAVRMAGPPH--PPSQPPPFLAAQF-----QMAAALAHHHQQQQQQQQQQL 221
            |       ...|:     .||..|  |...|||..||.|     ..|||..
Mouse    39 P-------PQYPD-----FAGYTHVEPAPAPPPTWAAPFPAPKDDWAAAYG-------------- 77

  Fly   222 PPVPT-----------GPP--HGPHPHLPPGQIPLGIF------PGGP-HPGHPPPHGHHPFGSA 266
             |.||           |||  ..|.| .|||..| ||.      ||.| .||.|        ...
Mouse    78 -PGPTASAASPAPLAFGPPPDFSPVP-APPGPGP-GILAQSLGAPGAPSSPGAP--------RRT 131

  Fly   267 PHLIRDSYPLYPWLLSRHGRIFPRFPGNFLFQPFRKPKRVRTAFSPTQLLKLEHAFEGNHYVVGA 331
            |         |.|:     |......|.......|...:.|..::..|.|:||..|..:.|:...
Mouse   132 P---------YEWM-----RRSVAAAGGGGSGKTRTKDKYRVVYTDHQRLELEKEFHYSRYITIR 182

  Fly   332 ERKQLAQGLSLTETQVKVWFQNRRTKH-----KRMQQEGG----------DGSDTKS 373
            .:.:||..|.|||.|||:||||||.|.     |:.||:..          ||:.|.|
Mouse   183 RKSELAANLGLTERQVKIWFQNRRAKERKVNKKKQQQQQPLPPTQLPLPLDGTPTPS 239

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeobox	307..359	CDD:278475	23/56 (41%)
Cdx1	NP_034010.3	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..152		59/228 (26%)
		Caudal_act	13..138	CDD:282574	51/193 (26%)
		Interaction with DNA. /evidence=ECO:0000250\|UniProtKB:P47902	157..178		6/20 (30%)
		Homeobox	158..210	CDD:278475	23/51 (45%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000250\|UniProtKB:P47902	196..207		8/10 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	209..268		7/31 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900