Protein Alignment E5 and Vsx1

DIOPT Version :10

• Sequence 1: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_473409.1
• Gene: Vsx1 / 114889
• MGIID: 1890816
• Length: 363
• Species: Mus musculus
• Alignment Length: 417
• Identity: 98/417 - (23%)
• Similarity: 138/417 - (33%)
• Gaps: 132/417 - (31%)

  Fly   106 RDSLDRSRSPQRSPVSRSPSPPNAGG------------------NPAAAGNTAKSGDPSSGTGNP 152
            ||.|..:||..|   :.:|..|..|.                  .||..|..:.||||:...|:.
Mouse     4 RDGLSDARSRSR---ALAPGCPPTGSRLRSFAINDLLGLEADLPTPAEPGLRSNSGDPAEAIGSG 65

  Fly   153 PTLIRPLPLPAPNLALIGNRTSPNAMAVRMAGPPHPPSQPPPFLAAQFQMAAALAHHHQQQQQQQ 217
                     |.|...|.|:..:..|:.:.:.......:|||...||.......||
Mouse    66 ---------PGPGPGLCGSCPARGALPLGLGLLCGFGAQPPSAAAAARARCLLLA---------- 111

  Fly   218 QQQLPPVPTGPPHGPHPHLPPGQIPLGIFPGGPHPGHPPPH-GHH--------PFGSAPHLIRDS 273
              .|..:|:.   ||.|.:..|            |.||||. |..        ..|.:|...::.
Mouse   112 --DLRLLPSA---GPEPAVAQG------------PVHPPPALGSQQRSESVSTSDGDSPSEEKND 159

  Fly   274 YPLYPWLLSRHGRIFPRFPGNFLFQPFRKPKRVRTAFSPTQLLKLEHAFEGNHYVVGAERKQLAQ 338
             |....:|.:                 ||.:|.||.|:..||.:||.||...||.....|:.||.
Mouse   160 -PKMSLILGK-----------------RKKRRHRTVFTAHQLEELEKAFGEAHYPDVYAREMLAA 206

  Fly   339 GLSLTETQVKVWFQNRRTKHKRMQQEGGDGS-------------------DTKSNKGSSSGGG-- 382
            ...|.|.:::|||||||.|.::.::..|..|                   |:..|...|..|.
Mouse   207 KTELPEDRIQVWFQNRRAKWRKREKRWGGSSVMAEYGLYGAMVRHCIPLPDSVLNSADSLQGSCA 271

  Fly   383 -----------GGGDGEDDAKHDG---SQHSYEDAEDPEDEDEIEEDD---------EDEVIDMD 424
                       |....|.:.|..|   ..|..:.|...||..|...|:         ||..||:
Mouse   272 PWLLGMHKKSTGMRKPESEDKLAGLWEFDHLKKGANKDEDGPERGPDETTQNPENSLEDVAIDL- 335

  Fly   425 DYGSEMDAEEHQRLREQFQQQLAQHQQ 451
               |....:|.:::......||.|..|
Mouse   336 ---SSSSRQETKKMPPGSSTQLPQPPQ 359

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	25/55 (45%)
Vsx1	NP_473409.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..25		8/23 (35%)
		Octapeptide motif	31..38		0/6 (0%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	42..66		8/32 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	122..166		11/56 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	168..173		2/21 (10%)
		Homeodomain	172..228	CDD:459649	25/55 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..363		16/64 (25%)