Protein Alignment E5 and CDX4

DIOPT Version :10

• Sequence 1: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_005184.1
• Gene: CDX4 / 1046
• HGNCID: 1808
• Length: 284
• Species: Homo sapiens
• Alignment Length: 264
• Identity: 66/264 - (25%)
• Similarity: 91/264 - (34%)
• Gaps: 75/264 - (28%)

  Fly   170 GNRTSPNAMAVRMAGPPHPPSQPPPFLAAQFQMAAALAHHHQQQQQQQQQQLPPVPTGPPHGP-- 232
            |...||........|.......|.|  |:.|..|.|.:|:         ...|.:|:..||.|
Human    16 GTLMSPGGDGTAGTGGTGGGGSPMP--ASNFAAAPAFSHY---------MGYPHMPSMDPHWPSL 69

  Fly   233 ----HPHLPP--------------GQIP------------------LGIFPGGPH----PGHP-- 255
                .|:.||              |.:|                  ||...||..    ||..
Human    70 GVWGSPYSPPREDWSVYPGPSSTMGTVPVNDVTSSPAAFCSTDYSNLGPVGGGTSGSSLPGQAGG 134

  Fly   256 ---PPHGHHPFGSAPHLIRDSYPLYPWLLSRHGRIFPRFPGNFLFQPFRKPKRVRTAFSPTQLLK 317
               |........|:|.  |..:..|.|:     |...:..|.     .|..::.|..::..|.|:
Human   135 SLVPTDAGAAKASSPS--RSRHSPYAWM-----RKTVQVTGK-----TRTKEKYRVVYTDHQRLE 187

  Fly   318 LEHAFEGNHYVVGAERKQLAQGLSLTETQVKVWFQNRRTKHKRM-----QQEGGDGSDTKSNKGS 377
            ||..|..|.|:....:.:||..|.|:|.|||:||||||.|.::|     .|....|...:|:..|
Human   188 LEKEFHCNRYITIQRKSELAVNLGLSERQVKIWFQNRRAKERKMIKKKISQFENSGGSVQSDSDS 252

  Fly   378 SSGG 381
            .|.|
Human   253 ISPG 256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	23/55 (42%)
CDX4	NP_005184.1	Caudal_act	13..170	CDD:461413	35/176 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	15..40		5/23 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	120..155		8/36 (22%)
		Homeodomain	175..230	CDD:459649	23/54 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	238..259		6/19 (32%)