Protein Alignment E5 and CDX1

DIOPT Version :10

• Sequence 1: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_001795.2
• Gene: CDX1 / 1044
• HGNCID: 1805
• Length: 265
• Species: Homo sapiens
• Alignment Length: 265
• Identity: 71/265 - (26%)
• Similarity: 96/265 - (36%)
• Gaps: 74/265 - (27%)

  Fly   156 IRPLPLPAPNLALIGNRTSPNAMAVRMAGPPHPPSQPPPFLAAQFQMAAALAHHHQQQQQQQQQQ 220
            :.|.|....:|.|     .|.|.     |||.||..||     |:...::.:|       .:...
Human    13 VYPGPARPASLGL-----GPQAY-----GPPAPPPAPP-----QYPDFSSYSH-------VEPAP 55

  Fly   221 LPPVPTGPP-----------HGPHPHLPPGQIPLGIFPGGPHPGHPPPHGHHPFGSAPHLIRDSY 274
            .||...|.|           :||.|..|... |..:..|.|....|.|   .|.|..|.|:  :.
Human    56 APPTAWGAPFPAPKDDWAAAYGPGPAAPAAS-PASLAFGPPPDFSPVP---APPGPGPGLL--AQ 114

  Fly   275 PLYPWLLSRHGRIFPRFPGNFLFQPF------------------RKPKRVRTAFSPTQLLKLEHA 321
            ||       .|...|..||.....|:                  |...:.|..::..|.|:||..
Human   115 PL-------GGPGTPSSPGAQRPTPYEWMRRSVAAGGGGGSGKTRTKDKYRVVYTDHQRLELEKE 172

  Fly   322 FEGNHYVVGAERKQLAQGLSLTETQVKVWFQNRRTK----HKRMQQEGGDGSD------TKSNKG 376
            |..:.|:....:.:||..|.|||.|||:||||||.|    :|:.||:......      |.:..|
Human   173 FHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERKVNKKKQQQQQPPQPPMAHDITATPAG 237

  Fly   377 SSSGG 381
            .|.||
Human   238 PSLGG 242

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeodomain	304..360	CDD:459649	23/59 (39%)
CDX1	NP_001795.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	9..153		39/174 (22%)
		Caudal_act	13..142	CDD:461413	39/163 (24%)
		Homeodomain	156..211	CDD:459649	23/54 (43%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536	157..178		6/20 (30%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536	196..207		8/10 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..265		9/36 (25%)