Protein Alignment E5 and CDX1

DIOPT Version :9

• Sequence 1: NP_524825.1
• Gene: E5 / 45396
• FlyBaseID: FBgn0008646
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_001795.2
• Gene: CDX1 / 1044
• HGNCID: 1805
• Length: 265
• Species: Homo sapiens
• Alignment Length: 265
• Identity: 71/265 - (26%)
• Similarity: 96/265 - (36%)
• Gaps: 74/265 - (27%)

  Fly   156 IRPLPLPAPNLALIGNRTSPNAMAVRMAGPPHPPSQPPPFLAAQFQMAAALAHHHQQQQQQQQQQ 220
            :.|.|....:|.|     .|.|.     |||.||..||     |:...::.:|       .:...
Human    13 VYPGPARPASLGL-----GPQAY-----GPPAPPPAPP-----QYPDFSSYSH-------VEPAP 55

  Fly   221 LPPVPTGPP-----------HGPHPHLPPGQIPLGIFPGGPHPGHPPPHGHHPFGSAPHLIRDSY 274
            .||...|.|           :||.|..|... |..:..|.|....|.|   .|.|..|.|:  :.
Human    56 APPTAWGAPFPAPKDDWAAAYGPGPAAPAAS-PASLAFGPPPDFSPVP---APPGPGPGLL--AQ 114

  Fly   275 PLYPWLLSRHGRIFPRFPGNFLFQPF------------------RKPKRVRTAFSPTQLLKLEHA 321
            ||       .|...|..||.....|:                  |...:.|..::..|.|:||..
Human   115 PL-------GGPGTPSSPGAQRPTPYEWMRRSVAAGGGGGSGKTRTKDKYRVVYTDHQRLELEKE 172

  Fly   322 FEGNHYVVGAERKQLAQGLSLTETQVKVWFQNRRTK----HKRMQQEGGDGSD------TKSNKG 376
            |..:.|:....:.:||..|.|||.|||:||||||.|    :|:.||:......      |.:..|
Human   173 FHYSRYITIRRKSELAANLGLTERQVKIWFQNRRAKERKVNKKKQQQQQPPQPPMAHDITATPAG 237

  Fly   377 SSSGG 381
            .|.||
Human   238 PSLGG 242

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
E5	NP_524825.1	Homeobox	307..359	CDD:278475	23/55 (42%)
CDX1	NP_001795.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	9..153		39/174 (22%)
		Caudal_act	13..138	CDD:282574	39/159 (25%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536	157..178		6/20 (30%)
		Homeobox	158..210	CDD:278475	23/51 (45%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536	196..207		8/10 (80%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..265		9/36 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0850
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X14
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810