DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spin and Spns1

DIOPT Version :9

Sequence 1:	NP_524823.1	Gene:	spin / 45380	FlyBaseID:	FBgn0086676	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_076201.2	Gene:	Spns1 / 73658	MGIID:	1920908	Length:	528	Species:	Mus musculus

Alignment Length:	525	Identity:	247/525 - (47%)
Similarity:	319/525 - (60%)	Gaps:	79/525 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 PGIP-------------PSAVVPSRLSSVGRS-QWFTVTVLCFVNLINYMDRFTIAGVLTDVRND 144
            ||:|             |......|::.:.|. ....|.|||::||:|||||||:||||||:...
Mouse    25 PGLPGPMGNPKSGELEVPDCEGLQRITGLSRGHSTLIVVVLCYINLLNYMDRFTVAGVLTDIEQF 89

  Fly   145 FDIGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFM-KQFGWFIA 208
            |:||:.|.||:||||:.||||.||:||||||||:|.::|..|:..||..||..||: ::..|.:.
Mouse    90 FNIGDGSTGLIQTVFISSYMVLAPVFGYLGDRYNRKYLMCGGIAFWSLVTLGSSFIPREHFWLLL 154

  Fly   209 F-RALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWA 272
            . |.|||:|||||||||||:|:||||.|.||:||::||||||||||||||.|||...:|.||.||
Mouse   155 LTRGLVGVGEASYSTIAPTLIADLFVADQRSRMLSIFYFAIPVGSGLGYIAGSKVKDVAGDWHWA 219

  Fly   273 LRVTPILGIVAVFLI-LLIKDPVRG----HSEGSHNLEATTYKQDIKALVRNRSFMLSTAGFTCV 332
            |||||.||::||.|: |::::|.||    || ||..|..|::..|:|||.||.||:||:.|||.|
Mouse   220 LRVTPGLGVLAVLLLFLVVQEPPRGAVERHS-GSPPLSPTSWWADLKALARNPSFVLSSLGFTSV 283

  Fly   333 AFVAGALAWWGPSF-----IYLG--MKMQPGNENIVQDDVAFNFGVITMLAGLLGVPLGSFLSQY 390
            |||.|:||.|.|:|     :.||  ....||:.....|.:.  ||:||.|.|:|||.||..:|:.
Mouse   284 AFVTGSLALWAPAFLLRSRVVLGETPPCLPGDSCSSSDSLI--FGLITCLTGVLGVGLGVEISRR 346

  Fly   391 LVKRYPTADPVICAFGLLVSAPLLTGACLLVNSNSVGTYALIFFGQLALNLNWAIVADILLYVVV 455
            |.:..|.|||::||.|||.|||.|..|......:.|.||..||.|:..|::|||||||||||||:
Mouse   347 LRRFNPRADPLVCAAGLLGSAPFLFLALACARGSIVATYIFIFIGETLLSMNWAIVADILLYVVI 411

  Fly   456 PTRRSTAEAFQILISHALGDAGSPYLVGAISEAIMKHLHKNPSDSGLTTELRSMSQVAGSAISNA 520
            ||||||||||||::||.|||||||||:|.||:.:.:
Mouse   412 PTRRSTAEAFQIVLSHLLGDAGSPYLIGLISDRLRR----------------------------- 447

  Fly   521 TQVIAEATTSLMETARSSASQEYSDVEQFEGLQYALFSTSFVEVLGGIFFIFTACFIIKDKYNAT 585
                               |...|.:.:|..||::|...:||..|||..|:.||.||..|:..|.
Mouse   448 -------------------SWPPSFLSEFRALQFSLMLCAFVGALGGAAFLGTAMFIEDDRRRAQ 493

  Fly   586 RGLQG 590
            ..:||
Mouse   494 LHVQG 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spin	NP_524823.1	MFS	117..489	CDD:119392	221/385 (57%)
spin	NP_524823.1	MFS_1	120..462	CDD:284993	198/355 (56%)
Spns1	NP_076201.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..38		3/12 (25%)
Spns1	NP_076201.2	MFS	62..450	CDD:119392	222/438 (51%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167833707
Domainoid	1	1.000	354	1.000	Domainoid score	I986
eggNOG	1	0.900	-	-		E2759_KOG1330
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H41530
Inparanoid	1	1.050	423	1.000	Inparanoid score	I1753
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56526
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000708
OrthoInspector	1	1.000	-	-		otm43810
orthoMCL	1	0.900	-	-		OOG6_101629
Panther	1	1.100	-	-	LDO	PTHR23505
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3710
SonicParanoid	1	1.000	-	-		X211
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.790