Protein Alignment spin and SLC2A3

DIOPT Version :10

• Sequence 1: NP_524823.1
• Gene: spin / 45380
• FlyBaseID: FBgn0086676
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_008862.1
• Gene: SLC2A3 / 6515
• HGNCID: 11007
• Length: 496
• Species: Homo sapiens
• Alignment Length: 470
• Identity: 91/470 - (19%)
• Similarity: 163/470 - (34%)
• Gaps: 120/470 - (25%)

  Fly    96 IPPSAVVPSRLSSVGRSQWFTVTVLCFVNLINYMDRFT---IAGVLTDVRNDFDIGNDSAGLLQT 157
            :.|:.:....::::|..|:...|     .:||..::..   |...|||..|    ...|..||.:
Human     6 VTPALIFAITVATIGSFQFGYNT-----GVINAPEKIIKEFINKTLTDKGN----APPSEVLLTS 61

  Fly   158 VFVISYMVCAPIFGYLG--------DRYSRPWIMAVGVGLWSTTTLLGSFM------KQFGWFIA 208
            ::.:|..:.: :.|.:|        :|:.|...|.: |.|.:.|.  |.||      |.....|.
Human    62 LWSLSVAIFS-VGGMIGSFSVGLFVNRFGRRNSMLI-VNLLAVTG--GCFMGLCKVAKSVEMLIL 122

  Fly   209 FRALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVG------SGLGYIVGSKTAHLAN 267
            .|.::|:.....:...|..|.::....:|.....|....|.||      .||.:|:||:..
Human   123 GRLVIGLFCGLCTGFVPMYIGEISPTALRGAFGTLNQLGIVVGILVAQIFGLEFILGSEEL---- 183

  Fly   268 DWRWALRVTPILGIVAVFLI---------------LLIKDPVRGHSEGSHNLEATTY-----KQD 312
               |.|    :||...:..|               |||.   |...|.:..:....:     .||
Human   184 ---WPL----LLGFTILPAILQSAALPFCPESPRFLLIN---RKEEENAKQILQRLWGTQDVSQD 238

  Fly   313 IKALVRNRSFMLSTAGFTCVAFVAGALAWWGPSFIYLGMKMQPGNENI---------------VQ 362
            |:.: ::.|..:|......|..:....::..|..|.:.:::......|               ||
Human   239 IQEM-KDESARMSQEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAGVQ 302

  Fly   363 DDVAFNFGVITMLAGLLGVPLGSFLSQYLVKRYPTADPVICAFGLLVSAPLLTGACLLVNSNSVG 427
            :.:....|     ||::.. :.:.:|.:||:|.......:...|.:.....|....||:..|..|
Human   303 EPIYATIG-----AGVVNT-IFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMTVSLLLKDNYNG 361

  Fly   428 T------YALIFFGQLALN---LNWAIVADILLYVVVPTRRSTAEAFQILISHALGDAG-----S 478
            .      ..|:|.....:.   :.|.|||::......|.              |:..||     |
Human   362 MSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPA--------------AMAVAGCSNWTS 412

  Fly   479 PYLVGAISEAIMKHL 493
            .:|||.:..:...:|
Human   413 NFLVGLLFPSAAHYL 427

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spin	NP_524823.1	MFS_spinster_like	117..571	CDD:340886	88/449 (20%)
SLC2A3	NP_008862.1	MFS_GLUT_Class1	12..456	CDD:340989	90/464 (19%)
		Important for selectivity against fructose. /evidence=ECO:0000269|PubMed:26176916	277..279		0/1 (0%)