DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment spin and spns2

DIOPT Version :9

Sequence 1:	NP_524823.1	Gene:	spin / 45380	FlyBaseID:	FBgn0086676	Length:	630	Species:	Drosophila melanogaster
Sequence 2:	NP_001077316.1	Gene:	spns2 / 568117	ZFINID:	ZDB-GENE-030131-5843	Length:	504	Species:	Danio rerio

Alignment Length:	577	Identity:	222/577 - (38%)
Similarity:	313/577 - (54%)	Gaps:	106/577 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 IQSSGS--SGSSSSEE----GGSREDVANLSPLGLPTTYSSQQLMPSDTDSMEEERHRLRPHHHH 83
            ::|.|.  .|.|||:|    .||      :||     ...|:.|                   ||
Zfish     3 VESDGCEIEGCSSSDEVHTLSGS------MSP-----ALKSRDL-------------------HH 37

  Fly    84 HHPLGEHHHIPGIPPSAVVPSRLSSVGRSQWFTVTVLCFVNLINYMDRFTIAGVLTDVRNDFDIG 148
            ..| |:..|      :|::..|...|...      :|.|.|::|||||:|:||||.|::..|.:|
Zfish    38 CRP-GQKFH------AALLRCRTPLVAAG------ILSFGNVLNYMDRYTVAGVLLDIQKQFKVG 89

  Fly   149 NDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFM-KQFGWFIAF-RA 211
            :.|||||||||:.|:||.||||||||||::|..|::.|:..||..|||.||: |::.|.:.. |.
Zfish    90 DSSAGLLQTVFICSFMVAAPIFGYLGDRFNRKIILSCGIFFWSAVTLLSSFITKEYYWLLVLSRC 154

  Fly   212 LVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWALRVT 276
            ||||||:|||:|:|||:.|||.::.|:.||::||.|||:|||||||:||........|.|||||:
Zfish   155 LVGIGESSYSSISPTIMGDLFTNNKRTVMLSVFYLAIPLGSGLGYILGSIAKDAGGHWYWALRVS 219

  Fly   277 PILGIVAVFLILL-IKDPVRGHSE--GSHNLEATTYKQDIKALVRNRSFMLSTAGFTCVAFVAGA 338
            |:||:.|..|||: :.:|.||.::  |......|::..|:|||.:|||::.|:.....|:|..||
Zfish   220 PMLGLTAGTLILIFVSEPKRGSADQPGGRLKTRTSWVCDMKALAKNRSYVFSSLASAAVSFATGA 284

  Fly   339 LAWWGPSFIYLGMKMQPGNENIVQDDVAFN----FGVITMLAGLLGVPLGSFLSQYLVKRYPTAD 399
            ...|.|.::.....:|...|:......:..    ||.||.:.|||||.:|:..::...::...||
Zfish   285 FGIWIPQYLVRAQVVQKSAESCTYQPCSSRDSLIFGAITCVTGLLGVVIGAVTTRLCRQKTERAD 349

  Fly   400 PVICAFGLLVSAPLLTGACLLVNSNSVGTYALIFFGQLALNLNWAIVADILLYVVVPTRRSTAEA 464
            |::||..:|.||..:....::...:.||.|..||.|:..|.|||||.||||:|||:||||:||.|
Zfish   350 PLVCAVSMLGSAIFICLIFVVAKKSIVGAYICIFIGETLLFLNWAITADILMYVVIPTRRATAVA 414

  Fly   465 FQILISHALGDAGSPYLVGAISEAIMKHLHKNPSDSGLTTELRSMSQVAGSAISNATQVIAEATT 529
            ||...||.|||||||||:|.||:::.:                          |.||
Zfish   415 FQGFTSHLLGDAGSPYLIGLISDSLQE--------------------------SYAT-------- 445

  Fly   530 SLMETARSSASQEYSDVEQFEGLQYALFSTSFVEVLGGIFFIFTACFIIKDKYNATR 586
                          |::.||..|.|||....||.||||:||:.||.|.:.|:..|.:
Zfish   446 --------------SEIWQFLSLGYALMLCPFVIVLGGMFFLATALFFLDDRDKAAK 488

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
spin	NP_524823.1	MFS	117..489	CDD:119392	178/380 (47%)
spin	NP_524823.1	MFS_1	120..462	CDD:284993	159/350 (45%)
spns2	NP_001077316.1	MFS	60..439	CDD:119392	178/378 (47%)
spns2	NP_001077316.1	MFS_1	61..422	CDD:284993	165/360 (46%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	370	1.000	Domainoid score	I861
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	427	1.000	Inparanoid score	I1720
OMA	1	1.010	-	-		QHG56526
OrthoDB	1	1.010	-	-		D360635at33208
OrthoFinder	1	1.000	-	-		FOG0000708
OrthoInspector	1	1.000	-	-		otm26002
orthoMCL	1	0.900	-	-		OOG6_101629
Panther	1	1.100	-	-	O	PTHR23505
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X211
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980