Protein Alignment spin and SPNS3

DIOPT Version :9

• Sequence 1: NP_524823.1
• Gene: spin / 45380
• FlyBaseID: FBgn0086676
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: NP_872344.3
• Gene: SPNS3 / 201305
• HGNCID: 28433
• Length: 512
• Species: Homo sapiens
• Alignment Length: 531
• Identity: 209/531 - (39%)
• Similarity: 292/531 - (54%)
• Gaps: 66/531 - (12%)

  Fly    86 PLGEHHHIPGIP----PSAVVPSRLSSVGRSQWFTVTVLCFVNLINYMDRFTIAGVLTDVRNDFD 146
            |.|.....|| |    |..:.|:..|......:....|||::||:|||:.|.|||||.|::..|.
Human    14 PGGLQGQSPG-PGRQCPPPITPTSWSLPPWRAYVAAAVLCYINLLNYMNWFIIAGVLLDIQEVFQ 77

  Fly   147 IGNDSAGLLQTVFVISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMK-QFGW-FIAF 209
            |.::.|||||||||...::.||:|||||||:||...|:.|:.|||...|..||:. ::.| |...
Human    78 ISDNHAGLLQTVFVSCLLLSAPVFGYLGDRHSRKATMSFGILLWSGAGLSSSFISPRYSWLFFLS 142

  Fly   210 RALVGIGEASYSTIAPTIISDLFVHDMRSKMLALFYFAIPVGSGLGYIVGSKTAHLANDWRWALR 274
            |.:||.|.|||||||||::.||||.|.|:::||:||..|||||||||::||....|..:||||||
Human   143 RGIVGTGSASYSTIAPTVLGDLFVRDQRTRVLAVFYIFIPVGSGLGYVLGSAVTMLTGNWRWALR 207

  Fly   275 VTPILGIVA-VFLILLIKDPVRG----HSEGSHNLEATTYKQDIKALVRNRSFMLSTAGFTCVAF 334
            |.|.|..|| :.||||:.||.||    ..||:.....:::.:|::.|.:|.||:.||.|.|.:||
Human   208 VMPCLEAVALILLILLVPDPPRGAAETQGEGAVGGFRSSWCEDVRYLGKNWSFVWSTLGVTAMAF 272

  Fly   335 VAGALAWWGPSF-----IYLGMKMQPGNENIVQDDVAFNFGVITMLAGLLGVPLGSFLSQYLVKR 394
            |.|||.:|.|.|     :..|::.....|.....| :..||.:|::.|::||.||:..::...|.
Human   273 VTGALGFWAPKFLLEARVVHGLQPPCFQEPCSNPD-SLIFGALTIMTGVIGVILGAEAARRYKKV 336

  Fly   395 YPTADPVICAFGLLVSAPLLTGACLLVNSNSVGTYALIFFGQLALNLNWAIVADILLYVVVPTRR 459
            .|.|:|:|||..||.:||.|..|.:|..:..:.:|..:..|:|.|:.|||:||||||.||||..|
Human   337 IPGAEPLICASSLLATAPCLYLALVLAPTTLLASYVFLGLGELLLSCNWAVVADILLSVVVPRCR 401

  Fly   460 STAEAFQILISHALGDAGSPYLVGAISEAIMKHLHKNPSDSGLTTELRSMSQVAGSAISNATQVI 524
            .||||.||.:.|.|||||||||.|.||..:
Human   402 GTAEALQITVGHILGDAGSPYLTGLISSVL----------------------------------- 431

  Fly   525 AEATTSLMETARSSASQEYSDVEQFEGLQYALFSTSFVEVLGGIFFIFTACFIIKDKYNATRGLQ 589
                       |:.....|  :::|..||.:....:||..|||..|:.||.::.:|:..|.:.:.
Human   432 -----------RARRPDSY--LQRFRSLQQSFLCCAFVIALGGGCFLLTALYLERDETRAWQPVT 483

  Fly   590 GDQGAQAVRSS 600
            |...:..|.|:
Human   484 GTPDSNDVDSN 494

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spin	NP_524823.1	MFS	117..489	CDD:119392	183/383 (48%)
		MFS_1	120..462	CDD:284993	163/353 (46%)
SPNS3	NP_872344.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..30		5/16 (31%)
		MFS	49..466	CDD:119392	194/465 (42%)
		MFS_1	51..414	CDD:284993	169/363 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	481..512		3/14 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165143551
Domainoid	1	1.000	350	1.000	Domainoid score	I1023
eggNOG	1	0.900	-	-		E2759_KOG1330
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	418	1.000	Inparanoid score	I1817
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG56526
OrthoDB	1	1.010	-	-		D360635at33208
OrthoFinder	1	1.000	-	-		FOG0000708
OrthoInspector	1	1.000	-	-		otm41757
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR23505
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X211
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	13	12.870