Protein Alignment spin and MFSD3

DIOPT Version :10

• Sequence 1: NP_524823.1
• Gene: spin / 45380
• FlyBaseID: FBgn0086676
• Length: 630
• Species: Drosophila melanogaster
• Sequence 2: XP_016868494.1
• Gene: MFSD3 / 113655
• HGNCID: 25157
• Length: 441
• Species: Homo sapiens
• Alignment Length: 543
• Identity: 108/543 - (19%)
• Similarity: 172/543 - (31%)
• Gaps: 178/543 - (32%)

  Fly    86 PLGEHHHIPGIP---PSAVVPSRLSSVGRSQWFTVTVLCFVNLINYMDRFTIAGVLTDVRNDFDI 147
            ||...:.:.|:|   .|.::|..|.:.|.|                         ||.|
Human     7 PLAGLYLVQGLPYGLQSGLLPVLLRAGGLS-------------------------LTRV------ 40

  Fly   148 GNDSAGLLQTVFV--ISYMVCAPIFGYLGDRYSRPWIMAVGVGLWSTTTLLGSFMKQFGWFIAFR 210
                 ||.:.::.  :..:..||:....|.  :|.|:.....||.....||......
Human    41 -----GLAKVLYAPWLLKLAWAPLVDAQGS--ARAWVTRSTAGLGLVCGLLAGLPPP-------- 90

  Fly   211 ALVGIGEASYSTIAPTIISDLF--------VHDMRSKMLAL-FYFAIPVGSG-----LGYIVGSK 261
               |.|:|.    .|..::.|.        :.|:....||: ......:|.|     :.|.:|:.
Human    91 ---GAGQAG----LPAAVAGLLLLLNLGAAMQDVALDALAVQLLEPAELGPGNTVQVVAYKLGAA 148

  Fly   262 TAHLANDWRWALRVTPILGIVAVFLILLIKDPVRGHSEGSHNLEATTYKQDIKALVRNRSFMLST 326
            .|..|     .|.:.|......:||:|                 |.||
Human   149 LAGGA-----LLALLPTFSWPQLFLLL-----------------AATY----------------- 174

  Fly   327 AGFTCVAFVAGALAWWGPSFIYLGMKMQPGNENIVQDDVAFNFGVITMLAGLLGVPLGSFLSQYL 391
                   ::|.||||..|:...|  ..||.:|.  :...|.      :|..:|.|| |:..:...
Human   175 -------WLAAALAWAAPALRRL--PQQPPSEQ--RPHTAH------LLRDVLAVP-GTVWTAGF 221

  Fly   392 VKRYPTADP-VICAFGLL-----VSAPLL-----TGA--CLLVNSNSVGTYALIFFGQLALNLNW 443
            |..|...:. ....|.||     ||||.|     .||  |.:..|:..||         .|..:|
Human   222 VLTYKLGEQGASSLFPLLLLDHGVSAPELGLWNGVGAVVCSIAGSSLGGT---------LLAKHW 277

  Fly   444 AIVADILLYVVVPTRRSTAEAFQILISH--ALG---DAGSPYLVGAISEAIMKHLHKNPSDSGLT 503
            .::.  ||..|:..|.........|:.|  .||   |||:.....|:....::|..     .||.
Human   278 KLLP--LLRSVLRFRLGGLACQTALVFHLDTLGASMDAGTILRGSALLSLCLQHFL-----GGLV 335

  Fly   504 TELRSMSQVAGSAISNATQVIAEATTSLMETARSSASQEYSDVEQF--EGLQYALFSTSFVEVLG 566
            |.:.....:..|.::.....::..:....||..........|.:..  :...|:|.:|  :|:||
Human   336 TTVTFTGMMRCSQLAPRALQVSRCSRDTRETTGLGLCGPDLDRDPHPPQATHYSLLAT--LELLG 398

  Fly   567 GIFFIFTA-----------CFII 578
            .:.....|           ||::
Human   399 KLLLGTLAGGLADGLGPHPCFLL 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
spin	NP_524823.1	MFS_spinster_like	117..571	CDD:340886	96/489 (20%)
MFSD3	XP_016868494.1	MFS_MFSD3	8..433	CDD:341038	107/542 (20%)