DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fwd and SH3PXD2A

DIOPT Version :9

Sequence 1:	NP_001356971.1	Gene:	fwd / 45374	FlyBaseID:	FBgn0004373	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_001380944.1	Gene:	SH3PXD2A / 9644	HGNCID:	23664	Length:	1133	Species:	Homo sapiens

Alignment Length:	988	Identity:	200/988 - (20%)
Similarity:	301/988 - (30%)	Gaps:	324/988 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FKGKKNSNPSC-------NSPMGSANGTAPVEAKPNNCYQYLRHIREID-------TNNKLLSPV 58
            :.||:...|:.       :.|....|...|||        .:.:|.||.       :.:|...|.
Human   308 YLGKEGWAPASYLKKAKDDLPTRKKNLAGPVE--------IIGNIMEISNLLNKKASGDKETPPA 364

  Fly    59 VVVAEERPVSK----------------AGSPS-TVATMATGVDVVDHCLPTTVRLSVTEA-LSDL 105
            .....|.|::|                .|.|. ||:.:|.|       .|...|::...| :|..
Human   365 EGEGHEAPIAKKEISLPILCNASNGSAVGVPDRTVSRLAQG-------SPAVARIAPQRAQISSP 422

  Fly   106 NMNGKAVEPPVTPCTSVGDNANLEVAETWACPPPQATDDEDISEHSTAACTSTSSSSEHSNSTVV 170
            |:.   ..||....:|:|          :..|.|......::..::.|...|..|
Human   423 NLR---TRPPPRRESSLG----------FQLPKPPEPPSVEVEYYTIAEFQSCIS---------- 464

  Fly   171 HSPTVGESTCDSVSVSVSHPSPSVSQNNTS---SATGRMSSPHSQSSLSIACEPH-SASTTTLSS 231
                      |.:|......:..:.:|:..   ...|........|.:....:|: |..|:||
Human   465 ----------DGISFRGGQKAEVIDKNSGGWWYVQIGEKEGWAPASYIDKRKKPNLSRRTSTL-- 517

  Fly   232 LGSDLGNGNGSTVPAFLMAAPVTLPIGGQM-PTIKCLPGASSAASTPKHSRYSKPRLSLSRVFNH 295
                       |.|.....||.:.|...:. ||     |||.:..:|:..:|.:|        .:
Human   518 -----------TRPKVPPPAPPSKPKEAEEGPT-----GASESQDSPRKLKYEEP--------EY 558

  Fly   296 SMPS--VHGRPNLSLAPA--GVPGSVNP--PKRISTHQRNLSLDFRSMGILLPPVSQVTNNHINH 354
            .:|:  ....|.||..|.  ...|...|  |.|.|                  |.|.:.......
Human   559 DIPAFGFDSEPELSEEPVEDRASGERRPAQPHRPS------------------PASSLQRARFKV 605

  Fly   355 TQHHRNRSLDSALQRIPEVEVSSPNAESENTFCSPSILGATMCSKIATTAATVTSALSPPGTPTP 419
            .:...:.:|:.  :.|.|.|...|.||.                       |:::..|...:.:|
Human   606 GESSEDVALEE--ETIYENEGFRPYAED-----------------------TLSARGSSGDSDSP 645

  Fly   420 ALMSTACTPTIGAVKGNVQHPVPKHEQSISLAAACRSSAVVESCPTLRMRPKSSESVAANGQEMI 484
            ...|.:.|.     |.:.:...||....:.|.|...:.|.:.       :..||.|.::
Human   646 GSSSLSLTR-----KNSPKSGSPKSSSLLKLKAEKNAQAEMG-------KNHSSASFSS------ 692

  Fly   485 GVIVSSTGNGSSSSNNSCSSAGSTKKREDLTSLGSDDSGIICGSESDQISLNRICHSHESLDSGE 549
                |.|.|.:..|::|.||:..:|...||....:.|:| |.|:...:               .:
Human   693 ----SITINTTCCSSSSSSSSSLSKTSGDLKPRSASDAG-IRGTPKVR---------------AK 737

  Fly   550 MDADADAEEECVDLMDTTSIDEEYNIMQPDHLCLYPPQAASTELDCRTLRPSRKQKRQQQQVLER 614
            .||||:|        ..||.......::|..........:..::|..||   |:|.|...|:  |
Human   738 KDADANA--------GLTSCPRAKPSVRPKPFLNRAESQSQEKMDISTL---RRQLRPTGQL--R 789

  Fly   615 KNLPSQNQIESEDSVDAGVDARTRYRVMNMSQAAINVELGTASNEIDPDVNYRESHQDPI---AD 676
            ..|...   :||||                       ||...:....|....|.|..|.|   |.
Human   790 GGLKGS---KSEDS-----------------------ELPPQTASEAPSEGSRRSSSDLITLPAT 828

  Fly   677 APSLST------PSVA-STASATPSVTPTPIATPTPTESTKNDQVLFKNFFGATKNAIFRTAQSI 734
            .|...|      |:.: .|.||...|..:.|:.|...|.    |||.|...| .....|...:..
Human   829 TPPCPTKKEWEGPATSYMTCSAYQKVQDSEISFPAGVEV----QVLEKQESG-WWYVRFGELEGW 888

  Fly   735 IENHEKKNAAKQKEQPDHSG----TVSLVGSPNGGSS---------------VPQDLVKSPTDIS 780
            ..:|..  ...:.||||.||    ||...|..|.|.|               |.|....:|...|
Human   889 APSHYL--VLDENEQPDPSGKELDTVPAKGRQNEGKSDSLEKIERRVQALNTVNQSKKATPPIPS 951

  Fly   781 KKKEFFSLLTSSSSIK-----AAAAAAANSAASTPP---------------ATPTEAL-AANSNS 824
            |....|...:.:.::|     ...|....|...:||               .|.|:.| ....||
Human   952 KPPGGFGKTSGTPAVKMRNGVRQVAVRPQSVFVSPPPKDNNLSCALRRNESLTATDGLRGVRRNS 1016

  Fly   825 KLQPLSDPSADLK--VKERTLNLRLPGDSEGSEGALTKCSSINSIHKLKLPVPGVVKYFISEKAP 887
            ........:|:.|  :.||..       |:||:..|..... |||                   |
Human  1017 SFSTARSAAAEAKGRLAERAA-------SQGSDSPLLPAQR-NSI-------------------P 1054

  Fly   888 VSDVLQKP-EKGQ 899
            ||.|..|| ||.|
Human  1055 VSPVRPKPIEKSQ 1067

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712
SH3PXD2A	NP_001380944.1	PX_FISH	6..124	CDD:132798
		SH3_Tks5_1	170..222	CDD:213007
		SH3_Tks5_2	269..322	CDD:213010	3/13 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	415..446		9/43 (21%)
		SH3_Tks5_3	451..504	CDD:213012	8/72 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	505..840		96/480 (20%)
		SH3_Tks5_4	844..896	CDD:212952	14/58 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	899..924		11/24 (46%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	941..964		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1029..1059		13/56 (23%)
		SH3_Tks5_5	1076..1132	CDD:212953
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900