DRSC/TRiP Functional Genomics Resources

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Protein Alignment fwd and MEC1

DIOPT Version :9

Sequence 1:NP_001356971.1 Gene:fwd / 45374 FlyBaseID:FBgn0004373 Length:1682 Species:Drosophila melanogaster
Sequence 2:NP_009694.3 Gene:MEC1 / 852433 SGDID:S000000340 Length:2368 Species:Saccharomyces cerevisiae


Alignment Length:1335 Identity:237/1335 - (17%)
Similarity:392/1335 - (29%) Gaps:542/1335 - (40%)


- Green bases have known domain annotations that are detailed below.


  Fly   735 IENHE-KKNAAKQKEQPDHSGTVSLVGSPNGGSSVPQDLVKSPTDI---------SKKKEFFSLL 789
            :..|| |:....:.|..|.:.:|..:          :.|:....||         :..|:.|..|
Yeast  1128 VTKHEFKRTTYSENEVYDLNDSVQTI----------KFLIWVINDILVPAFWQSENPSKQLFVAL 1182

  Fly   790 TSSSSIKAAAAAAANSAASTPPATPTEA---------------------LAANSNSKLQPLSDPS 833
            ....|:|....::.:...:.....|.||                     ..|.|..:..||..||
Yeast  1183 VIQESLKYCGLSSESWDMNHKELYPNEAKLWEKFNSVSKTTIYPLLSSLYLAQSWKEYVPLKYPS 1247

  Fly   834 ADLK------VKERTLNLRLPGDSEGSEGALTKCSSI-----NSIHKLKLPVPGVVKYFISEKAP 887
            .:.|      ||..||:|...|.:|..  .|...||:     .|:....||       :||    
Yeast  1248 NNFKEGYKIWVKRFTLDLLKTGTTENH--PLHVFSSLIREDDGSLSNFLLP-------YIS---- 1299

  Fly   888 VSDVLQKPEKGQ------SGLLRFFES------------PVFNIHFAVHYLF------------- 921
             .|::.|.|||.      :|::..|:|            .|.::......:|             
Yeast  1300 -LDIIIKAEKGTPYADILNGIIIEFDSIFTCNLEGMNNLQVDSLRMCYESIFRVFEYCKKWATEF 1363

  Fly   922 ---YSKEPG-----------VLSFIGNKIFSFPDQ-------EVD------LYIPQ--------- 950
               |||..|           :|..|...:.:.|..       |.|      ||:.|         
Yeast  1364 KQNYSKLHGTFIIKDTKTTNMLLRIDEFLRTTPSDLLAQRSLETDSFERSALYLEQCYRQNPHDK 1428

  Fly   951 ---------LVVMYIQ---MDELAEVL------------------------------------DP 967
                     |.:.|.:   :|.|..||                                    ||
Yeast  1429 NQNGQLLKNLQITYEEIGDIDSLDGVLRTFATGNLVSKIEELQYSENWKLAQDCFNVLGKFSDDP 1493

  Fly   968 YLTIRCRKSVDFSLKCLWLLEAYNYQVDS--LGNSHNSSRKSKLAL---MKEIFS---------- 1017
            ..|.|..||:            |::|:.|  :.||...|...|::|   :||.:|          
Yeast  1494 KTTTRMLKSM------------YDHQLYSQIISNSSFHSSDGKISLSPDVKEWYSIGLEAANLEG 1546

  Fly  1018 -----------------------------------------KREHKQTQNDLKSAGTGGLHVGEP 1041
                                                     .|..|...|..:..||..:...:.
Yeast  1547 NVQTLKNWVEQIESLRNIDDREVLLQYNIAKALIAISNEDPLRTQKYIHNSFRLIGTNFITSSKE 1611

  Fly  1042 RSVVA---LAKKTH--------------HRSQSDATVL-------LADFRSPHTLSISHRMYQQP 1082
            .:::.   |..|.|              ...:|:.|:|       .|||...|.:....:.:.|.
Yeast  1612 TTLLKKQNLLMKLHSLYDLSFLSSAKDKFEYKSNTTILDYRMERIGADFVPNHYILSMRKSFDQL 1676

  Fly  1083 PYTTQTLPTTPAKLCLGDLTSGHAFDNGCTCFETVRGQVNGLLGQRTLCSCGAPKTSPQK--EFM 1145
            ....|           .|...|..|   .|..:..|......:...:|..| ..:..||.  ||.
Yeast  1677 KMNEQ-----------ADADLGKTF---FTLAQLARNNARLDIASESLMHC-LERRLPQAELEFA 1726

  Fly  1146 KALMNVGKN------LTSWPSKAEKTSALRMS------------LNLINKNLPARVWLPLYSDI- 1191
            :.|...|:|      :.....|.::.|::...            |:|.|.:...:: :..|.|| 
Yeast  1727 EILWKQGENDRALKIVQEIHEKYQENSSVNARDRAAVLLKFTEWLDLSNNSASEQI-IKQYQDIF 1790

  Fly  1192 --------PHHVV-----RITEEKTA---VLNSKDKTPYIIY---------VEVVE-IPDIYT-- 1228
                    |::.:     |:.|.|.|   :.|.:.:...|.|         .:|.| :|.:.|  
Yeast  1791 QIDSKWDKPYYSIGLYYSRLLERKKAEGYITNGRFEYRAISYFLLAFEKNTAKVRENLPKVITFW 1855

  Fly  1229 ----------SPLIPKMMPS-------------LRHTKSE------EHLDGSCLNSHQ------- 1257
                      :|...|.|.|             |:|..:.      ..|....|:|||       
Yeast  1856 LDIAAASISEAPGNRKEMLSKATEDICSHVEEALQHCPTYIWYFVLTQLLSRLLHSHQSSAQIIM 1920

  Fly  1258 HLSCSRTSSCSSSQQGTSCRRKKGADVDGGCGDAGPH---------NSCSNVHSLGGLQFQED-D 1312
            |:..|......|                        |         ||.|:...|.|....|. .
Yeast  1921 HILLSLAVEYPS------------------------HILWYITALVNSNSSKRVLRGKHILEKYR 1961

  Fly  1313 VWSQEEDEITAQYLNMRKVSERDTISQISLDSCDSRDQGPPVVFNIGDVRLRHCSNLSCENTKSF 1377
            ..||...::.:..|::.|...|..:..:.  |..||                  |..|.|  |.|
Yeast  1962 QHSQNPHDLVSSALDLTKALTRVCLQDVK--SITSR------------------SGKSLE--KDF 2004

  Fly  1378 SNDPE-DPSAAALK-------------------EPWHEKEKLIRESSPY---GHLSNWRLLSAIV 1419
            ..|.. .|||..:.                   :|:.....:||..|.|   ..|...:.|:.|.
Yeast  2005 KFDMNVAPSAMVVPVRKNLDIISPLESNSMRGYQPFRPVVSIIRFGSSYKVFSSLKKPKQLNIIG 2069

  Fly  1420 KCG---------DDLRQELMATQLLQMFKIIWQEE----QVDLWVRPYKIVCLSNDSGLIEPILN 1471
            ..|         :|:||:....|.......:..::    :..|.:..|.::.|..|.|::|.:.|
Yeast  2070 SDGNIYGIMCKKEDVRQDNQYMQFATTMDFLLSKDIASRKRSLGINIYSVLSLREDCGILEMVPN 2134

  Fly  1472 TVSLHQIKKNSNKSLK------------------------------------EYFIDEYGSPSGE 1500
            .|:|..|.....:|||                                    ::|::.:..|.  
Yeast  2135 VVTLRSILSTKYESLKIKYSLKSLHDRWQHTAVDGKLEFYMEQVDKFPPILYQWFLENFPDPI-- 2197

  Fly  1501 SFRRAQKNFVQSCAAYCLISYLLQVKDRHNGNILFH-SDGHIIHIDFGFILSISPKNLGFEQSPF 1564
            ::..|:..:.:|.|...::.::|.:.|||..|||.. ..|.::|:||..:.....:....|..||
Yeast  2198 NWFNARNTYARSYAVMAMVGHILGLGDRHCENILLDIQTGKVLHVDFDCLFEKGKRLPVPEIVPF 2262

  Fly  1565 KLTPEFVEVMG--GTSSEHWREFNKLLLVGMMSARKHMDRIINFVEIMRSNAHLPCFKNGCSGTV 1627
            :|||..::.:|  ||..    .|.|...|.:...||:...::|.:|.:.                
Yeast  2263 RLTPNLLDALGIIGTEG----TFKKSSEVTLALMRKNEVALMNVIETIM---------------- 2307

  Fly  1628 QNLRKRFHMNLTEQEMERKVEQLVQDSLKSLSTKL 1662
                           .:|.::..:|.:||.|..|:
Yeast  2308 ---------------YDRNMDHSIQKALKVLRNKI 2327

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fwdNP_001356971.1 PI4Kc_III_beta 1385..1674 CDD:270712 66/352 (19%)
MEC1NP_009694.3 TEL1 194..2368 CDD:227365 237/1335 (18%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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