DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fwd and Pik3cb

DIOPT Version :9

Sequence 1:	NP_001356971.1	Gene:	fwd / 45374	FlyBaseID:	FBgn0004373	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_445933.1	Gene:	Pik3cb / 85243	RGDID:	620917	Length:	1070	Species:	Rattus norvegicus

Alignment Length:	911	Identity:	197/911 - (21%)
Similarity:	346/911 - (37%)	Gaps:	257/911 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   855 EGALTKCSSINSIHKLKLPVP----GVVKYFISEKAPVSDVLQKPEKGQSGLLRFFESPVFNIHF 915
            |.|:.:.||     .|.||:|    .|:.:......|...||.|..|..:      |..|
  Rat   301 EAAINRNSS-----SLPLPLPPKKTRVISHVWGNNNPFQIVLVKGNKLNT------EETV----- 349

  Fly   916 AVHY---LFYSKEPGVLSFIGNKIFSFPDQ------EVDLYI---PQLV----VMYIQMDEL--- 961
            .||.   ||:..|....:.:.::|....|.      |.|:.|   |::.    .:|..:|::
  Rat   350 KVHVRAGLFHGTELLCKTVVSSEISGKNDHIWNEQLEFDINICDLPRMARLCFAVYAVLDKVKTK 414

  Fly   962 --AEVLDP--YLTIRCRKSVDFSLKCLW---LLEAYNYQVDSLGNSHNSSRKSKLALMKEIFSKR 1019
              .:.::|  |.|||....|.:.:  .|   ::..:..|:.| |:....|..|....::|:.:..
  Rat   415 KSTKTINPSKYQTIRKAGKVHYPV--AWVNTMVFDFKGQLRS-GDVILHSWSSFPDELEEMLNPM 476

  Fly  1020 EHKQTQNDLKSAGTGGLHVGEPRSVVALAKKTHHRSQSDATVLLADFRSPHTLSISHRMYQQPPY 1084
            ...||....::|  ..||:..|.:     ||                          :.|..||:
  Rat   477 GTVQTNPYAENA--TALHIKFPEN-----KK--------------------------QPYYYPPF 508

  Fly  1085 TTQTLPTTPAKLCLGDLTSGHAFDNGCTCFETVRGQV--NGLLGQ------------RTLCSCGA 1135
              ..:....|::..||  |.:....|...|..|..::  ...|.|            |..|....
  Rat   509 --DKIIEKAAEIASGD--SANVSSRGGKKFLAVLKEILDRDPLSQLCENEMDLIWTLRQDCRENF 569

  Fly  1136 PKTSPQKEFMKALMNVGKNLTSWPSKAEKTSALRMSLNLINKNLPARVWLPLYS-DIPHHVVRIT 1199
            |::.|     |.|:::     .| :|.|..:.|:..|.:..| ||.|..|.|.. :.|...||
  Rat   570 PQSLP-----KLLLSI-----KW-NKLEDVAQLQALLQIWPK-LPPREALELLDFNYPDQYVR-- 620

  Fly  1200 EEKTAV-----LNSKDKTPYII-YVEVVEIPDIYTSP----LIPKMMPSLR-------HTKSEEH 1247
              :.||     ::.::.:.|:: .|:|::........    |:.:.:.:.|       |.:||.|
  Rat   621 --EYAVGCLRQMSDEELSQYLLQLVQVLKYEPFLDCALSRFLLERALDNRRIGQFLFWHLRSEVH 683

  Fly  1248 -----------LDGSCLNSHQH----------LSCSRTSSCSSSQQGTSCRRKKGADVDGGCGDA 1291
                       |:..|..|..|          |:..:|.:...........|.||.:
  Rat   684 TPAVSIQFGVILEAYCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAMKLNRAKGKE-------- 740

  Fly  1292 GPHNSCSNVHSLGGLQFQEDDVWSQEEDEITAQYLNMRKVSERDTISQISLDSCDSRDQGP--PV 1354
                                           |.:..:::.:.|:.:|.:         |.|  |.
  Rat   741 -------------------------------AMHTCLKQSAYREALSDL---------QSPLNPC 765

  Fly  1355 VFNIGDVRLRHCSNLSCENTKSFSNDPEDPSAAALKEPWHEKEKLIRESSPYGHLSNWRLLSAIV 1419
            |. :.::.:..|..:.                :.:|..|     |:..:..:|.    ..:..|.
  Rat   766 VI-LSELYVEKCRYMD----------------SKMKPLW-----LVYSNRAFGE----DAVGVIF 804

  Fly  1420 KCGDDLRQELMATQLLQMFKIIWQEEQVDLWVRPYKIVCLSNDSGLIEPILNTVSLHQIKKNS-- 1482
            |.||||||:::..|:|::..::|:|..:||.:.||..:...:.|||||.:..:.::..|:.||
  Rat   805 KNGDDLRQDMLTLQMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSN 869

  Fly  1483 -------NKSLKEYFIDEYGSPSGESFRRAQKNFVQSCAAYCLISYLLQVKDRHNGNILFHSDGH 1540
                   ||.....::.||.  ||:...||.:.|..|||.||:.||:|.:.|||:.||:....|.
  Rat   870 VAATAAFNKDALLNWLKEYN--SGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQ 932

  Fly  1541 IIHIDFGFILSISPKNLGF--EQSPFKLTPEFVEVM--GGT-SSEHWREFNKLLLVGMMSARKHM 1600
            :.|||||.||.......|.  |:.||.||.:|:.|:  |.| ::|.:..|.:......:..|:|.
  Rat   933 LFHIDFGHILGNFKSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHG 997

  Fly  1601 DRIINFVEIMRSNAHLP---CFKNGCSGTVQNLRKRFHMNLTEQEMERKVEQLVQDSLK-SLSTK 1661
            :..|....:|.: |.||   ..|:     :|.|:....:..:|:|..::.:|...::|: |.:||
  Rat   998 NLFITLFALMLT-AGLPELTSVKD-----IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTK 1056

  Fly  1662 L 1662
            :
  Rat  1057 V 1057

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	87/296 (29%)
Pik3cb	NP_445933.1	PI3K_p85B	41..118	CDD:197539
		PI3K_rbd	180..288	CDD:197540
		C2_PI3K_class_I_beta_delta	324..501	CDD:176075	41/223 (18%)
		Nuclear localization signal (NLS). /evidence=ECO:0000250	410..418		0/7 (0%)
		PI3Ka_I	532..702	CDD:238444	37/185 (20%)
		PI3Kc_IA_beta	706..1067	CDD:270717	100/434 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810