Protein Alignment fwd and ATPI4K ALPHA

DIOPT Version :10

• Sequence 1: NP_001356971.1
• Gene: fwd / 45374
• FlyBaseID: FBgn0004373
• Length: 1682
• Species: Drosophila melanogaster
• Sequence 2: NP_175359.2
• Gene: ATPI4K ALPHA / 841357
• AraportID: AT1G49340
• Length: 2028
• Species: Arabidopsis thaliana
• Alignment Length: 1912
• Identity: 397/1912 - (20%)
• Similarity: 663/1912 - (34%)
• Gaps: 568/1912 - (29%)

  Fly    69 KAGSPSTVATMATGVDVVDHCLPTTVR-LSVTEALSDLNMNGKA-----------------VEPP 115
            |......:.|:|..:|..|.||.:..| :...|.|.|..::|.|                 ::|.
plant   376 KTSKRLVLETLALLLDAADACLTSVWRKMKACEELFDSLLSGIAKIAVARGGQPLRVLLIRLKPL 440

  Fly   116 V-TPCTSVGDNANLE---------VAETWACPPPQATDDEDISEHSTAACTSTSSSSEHSNSTVV 170
            | ..|......|.||         :...|      |.|...:........:|....:::..
plant   441 VLAVCALPDQGAMLESIFKTSCVIIESAW------AKDRAPVDNFIMGLASSIRERNDYEE---- 495

  Fly   171 HSPTVGESTCDSVSVSVSHPSPSVSQNNTSSATGRMSSPHSQSSLSIACEPHSASTTTLSSLGSD 235
                         .|......|:|..|..          ...:.|::|.:....:...|......
plant   496 -------------QVDREKQVPAVQLNVI----------RLLADLNVAVKKPEVADMILPLFIES 537

  Fly   236 LGNGNGSTVPAFLMAAPVTLPIGGQMPTIKCLPGASSAASTPKHSRYSKPRLSLSRVFNHSMPSV 300
            |..|:.|| |:||              .::.|...|..|:......|.:..:.::|.:...:.||
plant   538 LEEGDAST-PSFL--------------RLQLLDAVSRIATLGFDKSYRETVVLMTRSYLSKLSSV 587

  Fly   301 HGRPNLSLAPAGVPGSVNPPKRISTHQRNLSLDFRSMGILLPPVSQVTNNHINHTQHHRNRSLDS 365
                      ..|....:.|:..:.....|...|      |...|.:.:..:.....||..||.|
plant   588 ----------GSVESKTSAPEATTERVETLPAGF------LTIASGLMDTKLRSDYRHRLLSLCS 636

  Fly   366 ALQRIPEVEVSSPNAESENTFCSPSILG------ATMCSKIATTAATVTS--------------- 409
                  :|.::   |||::.......||      |.:||....|.....|
plant   637 ------DVGLA---AESKSGGSGVDFLGPLLPAVAEICSDFDPTMDVEPSLLKLFRNLWFYIALF 692

  Fly   410 ALSPP--GTPTPALMSTA-CTPTIGAVKGNVQHPVP---KHEQSISLAAACRSSAVVESCPTLRM 468
            .|:||  .||||.|.||: ...::|::.......|.   ..:...:||.    ..:.:..|.|.:
plant   693 GLAPPIVKTPTPPLKSTSNSVNSVGSMSATALQAVGGPYMWDNQWALAV----QRIAQGTPPLVV 753

  Fly   469 RPKSSESVAANGQEMIGVIVSSTGNGSSSSNNSCSSAGSTKKREDLTSLGSDDSGIICGSESDQI 533
               ||.....:..|:     ::..|..|...|......||::....|:|         |...|..
plant   754 ---SSVKWLEDELEL-----NALHNPGSRRGNGNEKVASTQRLALSTAL---------GGRVDVA 801

  Fly   534 SLNRICH------------------SHESLDSGEMDADADAEE-ECVDLMDTTSIDEEYNIMQPD 579
            ::|.|..                  |:..:.:||....|.... .||         .||
plant   802 AMNTISGVKATYLLAVAFLEIIRFISNGGILNGESSVSASRSAFSCV---------FEY------ 851

  Fly   580 HLCLYPPQAASTELDCRTLRPSRKQKRQQQQVLERKNLPSQNQIESEDSVDAGVDARTR------ 638
               |..|........|.|            .::.|....:.:.:|...|: .|.|||.|
plant   852 ---LKTPNLTPAVSQCLT------------AIVHRAFETAVSWLEDRISL-TGKDARNRELTTYA 900

  Fly   639 ---YRVMNMSQ-----AAINVELGTASNEIDPDVNYRESHQDPIADAPSLSTPSVASTASATPSV 695
               :.:.:|||     ..|:|.|.|...:..|.|.:..|..|.:..:...:|||
plant   901 HACFLIKSMSQRDEHVRDISVNLLTQLRDKFPQVLWHSSCLDSLLFSVHDNTPS----------- 954

  Fly   696 TPTPIATPTPTESTKN-DQVLFKNFFGATKNAIFRTAQSIIENHEKKNAAKQKEQPDHSGTVSLV 759
              |.:..|..|.:.:: .|.:.:.:...:.:....|:|.::::...|....|:.|.. :..|||:
plant   955 --TVVNDPAWTAAVRSLYQKVVREWIIISLSYAPCTSQGLLQDKLCKANTWQRAQTT-TDVVSLL 1016

  Fly   760 GSPNGGSSVPQDLVKSPTDISKKKEFFSLLTSSS--SIKAAAAAAANSAASTPPATPTEALAANS 822
            .....|:.              |.|.:|.:.:::  ::.||||||:
plant  1017 SEIKIGTG--------------KNELWSGIRTANIPAVMAAAAAAS------------------- 1048

  Fly   823 NSKLQPLSDPSADLKVKERTLNLRLPGDSEGSEGALTKCS---SINSIHKLKLPVPGVVKYFISE 884
                      .|:|||.| ..||.:.|  .|...|..||:   .|..:.:|...:.|    |.|.
plant  1049 ----------GANLKVSE-AFNLEVLG--TGVVSATVKCNHAGEIAGMRRLYNSIGG----FQSG 1096

  Fly   885 KAPVSDVLQKPEKGQSGLLR------FFESP-----VFN-------IHFAVHYLFYSKEPG---- 927
            ..|         .|..|.|:      |.::|     .||       :.....::..:::.|
plant  1097 STP---------SGFGGGLQRLISGAFSQAPQPEDDSFNEMLIARFVRLLQQFVNTAEKGGEVEK 1152

  Fly   928 -------------VLSFIGNK--------------------IFSFPD-QEVDLYI--------PQ 950
                         :||.:|.:                    ..|.|| .|..::|        ||
plant  1153 SQFRETCSQATALLLSNLGGESKTNVEGFSQLLRLLCWCPAYISTPDAMETGIFIWTWLVSAAPQ 1217

  Fly   951 LVVMYIQMDELAEVLDPYL-TIRCRKSVDFS---------------------------------L 981
            ||.:.     |||::|.:: ||..::.:..|                                 .
plant  1218 LVSLV-----LAELVDAWIWTIDTKRGLFASDVRYSGPAAKLRPHLSPGEPEDPPESDPVDQIVA 1277

  Fly   982 KCLWLLEAYNYQVDSLGNSHNSSRKSKLALMKEIFSKREHKQTQNDLK--------SAGT----- 1033
            ..|||    .:.:|......::|.:..|.|.:.:       |...||:        :|||
plant  1278 HRLWL----GFLIDRFEVVRHNSAEQLLLLGRML-------QRSTDLEWCFTRHPAAAGTFFSLM 1331

  Fly  1034 -------------------GGLHVGEPRSV-VALAKKTHHRSQSDATVLLADFRSPHTLSIS--- 1075
                               .||.:.|.|.. .:|....|.....|  |.:.:|.....||:|
plant  1332 LLGLKFCSCQTQGNMQKFRSGLQLLEDRIYRTSLGWFAHQPEWYD--VNIPNFCHSEALSVSVFV 1394

  Fly  1076 HRMYQQPPYTTQT----LPTTPAKLCLGDLTSGH-----AFDNGCTCFETVRGQVNGLLGQ---- 1127
            |.:..:...::|:    .|.....|.  |:|..:     ..|| .|..:..|.|:..:|.|
plant  1395 HFLSNELSESSQSDSKGKPRESGNLI--DVTDQYHPVWGEMDN-YTLGKEKRKQLLLMLCQHEAD 1456

  Fly  1128 ------RTLCSCGAP----KTSPQK--EFMKALMNVGKNL-----TSWPS----KAEKTSALR-- 1169
                  :.:.|..:|    |.|.:|  |:.|...:|...:     :.:|:    |:|.|..::
plant  1457 RLDVWAQPISSKDSPYSRLKISSEKWTEYAKTAFSVDPRIALSVASRFPANASVKSEVTQLVQTN 1521

  Fly  1170 -MSLNLINKNLPARVWLP--------LYSDIPH----HVVRITEEKTAVLNSKDKT-PYIIYVEV 1220
             :.|..|.:.||..| .|        |...:||    .:.:..|..|.......:. .|::.| :
plant  1522 IVDLRTIPEALPYFV-TPKNVEENSVLLQQLPHWAACSITQALEFLTPAYKGHPRVMAYVLRV-L 1584

  Fly  1221 VEIPDIYTSPLIPKMMPSLRHTKSEEHLDGSCLNSHQ-----------HLSCSRTSSCSSSQQGT 1274
            ...|....:..:|:::.|||:... ..::|..|.:.|           ||
plant  1585 ESYPPERVTFFMPQLVQSLRYDDG-RLVEGYLLRATQRSDIFAHILIWHL--------------- 1633

  Fly  1275 SCRRKKGADVDGGCGDAGPHNSCS--------NVHSLGGLQFQEDDVWSQEED------EITAQY 1325
                 :|.||.....|.....:.:        ..|.:.|......|::::|.|      .|:...
plant  1634 -----QGEDVQETPKDGSIDKNAAFQEILPQVRQHIIDGFSPNALDMFTREFDFFDKVTSISGVL 1693

  Fly  1326 LNMRKVSERDTISQISLDSCDSRDQGPPVVFNIGDVRLRHCSNLSCENTKSFSNDPEDPSAAALK 1390
            ..:.|...|..|.: .|:..:.  ||       .|:.|....|   :..:....|...|..:|.|
plant  1694 FPLPKEERRAGIRR-ELEKIEM--QG-------DDLYLPTAPN---KLVRGIRVDSGIPLQSAAK 1745

  Fly  1391 EPWHEKEKLIRESSPYGHLSNWRLLSAIVKCGDDLRQELMATQLLQMFKIIWQEEQVDLWVRPYK 1455
            .|......:|...   |..|:.:..:.|.|.|||.||:::|.|::.:.:.|:|...::|::.||.
plant  1746 VPIMITFNVIDRD---GDHSDVKPQACIFKVGDDCRQDVLALQVISLLRDIFQAAGLNLYLFPYG 1807

  Fly  1456 IVCLSNDSGLIEPILNTVSLHQIKKNSNKSLKEYFIDEYGSPSGESFRRAQKNFVQSCAAYCLIS 1520
            ::....:.|:||.:.||.|..|:.:.::..|.|.|..:||.....:|..|::||:.|.|.|.:.|
plant  1808 VLPTGAERGIIEVVPNTRSRSQMGETTDGGLYEIFQQDYGPVGSTTFETARENFLISSAGYAVAS 1872

  Fly  1521 YLLQVKDRHNGNILFHSDGHIIHIDFGFILSISP-KNLGFEQSPFKLTPEFVEVM---GGTSSEH 1581
            .|||.|||||||:||...|.::||||||||..|| .|:.||.:.|||:.|..:::   |...|:.
plant  1873 LLLQPKDRHNGNLLFDDVGRLVHIDFGFILETSPGGNMRFESAHFKLSHEMTQLLDPSGVMKSKT 1937

  Fly  1582 WREFNKLLLVGMMSARKHMDRIINFVEIMRSNAHLPCFKNGCSGTVQNLRKRFHMNLTEQEMERK 1646
            |.:|..|.:.|.::||:.||.||:.|::|..:. ||||..|  ..:.|||||||..::|:|....
plant  1938 WHQFVSLCVKGYLAARRQMDGIISTVQMMLESG-LPCFSRG--DPIGNLRKRFHPEMSEREAAHF 1999

  Fly  1647 VEQLVQDSLKSLSTKLYDGYQYYTNGI 1673
            :..:..|:....:|..||..||...||
plant  2000 MIHVCTDAYNKWTTAGYDLIQYLQQGI 2026

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	106/293 (36%)
ATPI4K ALPHA	NP_175359.2	PI4K_N	297..1469	CDD:437106	236/1311 (18%)
		PI3Ka	1489..1667	CDD:412275	33/200 (17%)
		PI4Kc_III_alpha	1728..2027	CDD:270711	108/305 (35%)