Protein Alignment fwd and pik3cb

DIOPT Version :9

• Sequence 1: NP_001356971.1
• Gene: fwd / 45374
• FlyBaseID: FBgn0004373
• Length: 1682
• Species: Drosophila melanogaster
• Sequence 2: NP_001072928.1
• Gene: pik3cb / 780390
• XenbaseID: XB-GENE-482674
• Length: 1065
• Species: Xenopus tropicalis
• Alignment Length: 782
• Identity: 161/782 - (20%)
• Similarity: 277/782 - (35%)
• Gaps: 268/782 - (34%)

  Fly   959 DELAEVLDPYLTIRCRKSVDFSLKCLWLLEAYNYQVDSLGNSHNSSRKSKLAL--MKEIFSK-RE 1020
            |||.|:|:|..|:|              ...|.....:|....:...|..::.  ..:|..| .|
 Frog   461 DELEEMLNPMGTVR--------------TNPYTENTTTLHIKFHDYSKEPISYPPFDKILEKAAE 511

  Fly  1021 HKQTQNDLKSAGTGGLHVGEPRSVVALAKKTHHRSQSDATVLLADFRSPHTLSISHRMYQQPPYT 1085
            ..:..:.|.::|.||             ||.:                   :.:...|.:.|
 Frog   512 IARNSDSLSTSGRGG-------------KKLN-------------------IELKEIMERDP--- 541

  Fly  1086 TQTLPTTPAKLCLGDLTSGHAFDNGCTCFETVRGQVNGLLGQRTLCSCGAPKTSPQKEFMKALMN 1150
                      ||       ...:|......|:|..          |....|.:.|     |.|::
 Frog   542 ----------LC-------QLSENEKDLIWTLRYD----------CRENFPGSLP-----KLLLS 574

  Fly  1151 VGKNLTSWPSKAEKTSALRMSLNLINKNLPARVWLPLYS-DIPHHVVRITEEKTAV-----LNSK 1209
            |     .| :|.|..:.|:..|.:.:| ||.|..|.|.. :.|...||    :.||     ::.:
 Frog   575 V-----KW-NKLEDVAQLQALLQIWSK-LPPRDALELLDFNYPDQYVR----EYAVNCLKPMSDE 628

  Fly  1210 DKTPYII-YVEVVEIPDIYTSP----LIPKMMPSLR-------HTKSEEH-----------LDGS 1251
            :.:.|:: .|:|::........    |:.:.:.:.|       |.:||.|           |:..
 Frog   629 ELSQYLLQLVQVLKYEPFLDCALSRFLLQRALDNRRIGQFLFWHLRSEVHNPAVSVQFGLLLEAY 693

  Fly  1252 CLNSHQHLSCSRTSSCSSSQQGTSCRRKKGADVDGGCGDAGPHNSCSNVHSLGGLQFQEDDVWSQ 1316
            |..|..|:..       .|:|                     ..:.:.:.:|.||
 Frog   694 CRGSVAHMKV-------LSRQ---------------------VEALNKLRTLNGL---------- 720

  Fly  1317 EEDEITAQYLNMRKVSERD--------------------------TISQISLDSC---DSRDQGP 1352
                |....:.:.||..:|                          |:|::.::.|   ||:.:..
 Frog   721 ----IKLNAVKLSKVKNKDNMHTCLRENAYKEALMHIQSPLNPSITLSELVVEKCKYMDSKMKPL 781

  Fly  1353 PVVFNIGDVRLRHCSNLSCENTKSFSNDPEDPSAAALKEPWHEKEKLIRESSPYGHLSNWRLLSA 1417
            .:|:                |.:.|.:|.                                 |..
 Frog   782 WIVY----------------NNRGFGSDS---------------------------------LGI 797

  Fly  1418 IVKCGDDLRQELMATQLLQMFKIIWQEEQVDLWVRPYKIVCLSNDSGLIEPILNTVSLHQIKKNS 1482
            |.|.||||||:::|.|||::..::|:|..:||.:.||..:...:..|.||.:....::..|:.:|
 Frog   798 IFKNGDDLRQDMLALQLLRLMDMLWKEAGLDLRIVPYGCLATGDRCGFIEVVSAAETIADIQLDS 862

  Fly  1483 ---------NKSLKEYFIDEYGSPSGESFRRAQKNFVQSCAAYCLISYLLQVKDRHNGNILFHSD 1538
                     ||.....:|.|  ..||:...||.:.|..|||.||:.:|:|.:.||||.||:....
 Frog   863 SNLAAAAAFNKDALLNWIKE--CHSGDDLERAIEEFTLSCAGYCVATYVLGIGDRHNDNIMVRKT 925

  Fly  1539 GHIIHIDFGFILS--ISPKNLGFEQSPFKLTPEFVEVM-----GGTSSEHWREFNKLLLVGMMSA 1596
            |.:.|||||.||.  .|...:..|:.||.||.:|:.|:     |.|  |.:..|.:......:..
 Frog   926 GQLFHIDFGHILGNFKSKFKIKRERGPFILTYDFIHVIQQGKPGNT--EKFGRFRQCCEDAYLIL 988

  Fly  1597 RKHMDRIINFVEIMRSNAHLPCFKNGCSGTVQNLRKRFHMNLTEQEMERKVEQLVQDSLK-SLST 1660
            |::.:.||....:|.: |.||  :......:|.::....:...|::..::..|...::|| |.:|
 Frog   989 RRNGNLIITLFALMLT-AGLP--ELSSVKDIQYVKDSLALGKKEEDALKQFRQKFDEALKESWTT 1050

  Fly  1661 KL 1662
            |:
 Frog  1051 KV 1052

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	81/295 (27%)
pik3cb	NP_001072928.1	PI3K_p85B	33..108	CDD:308030
		PI3K_rbd	171..279	CDD:307097
		C2_PI3K_class_I_beta_delta	328..495	CDD:176075	10/47 (21%)
		PI3Ka_I	533..697	CDD:238444	40/209 (19%)
		PI3Kc_IA_beta	701..1062	CDD:270717	99/450 (22%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	1	1.000