DRSC/TRiP Functional Genomics Resources

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Protein Alignment fwd and Pik3cb

DIOPT Version :9

Sequence 1:NP_001356971.1 Gene:fwd / 45374 FlyBaseID:FBgn0004373 Length:1682 Species:Drosophila melanogaster
Sequence 2:NP_083370.2 Gene:Pik3cb / 74769 MGIID:1922019 Length:1064 Species:Mus musculus


Alignment Length:898 Identity:198/898 - (22%)
Similarity:348/898 - (38%) Gaps:231/898 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   855 EGALTKCSSINSIHKLKLPVP----GVVKYFISEKAPVSDVLQKPEKGQSGLLRFFESPVFNIHF 915
            |.|:.:.||     .|.||:|    .|:.:......|....|.|..|..:      |..| .:|.
Mouse   295 EAAINRNSS-----NLPLPLPPKKTRVISHIWDNNNPFQITLVKGNKLNT------EETV-KVHV 347

  Fly   916 AVHYLFYSKEPGVLSFIGNKIFSFPDQ------EVDLYI---PQLV----VMYIQMDEL-----A 962
            ... ||:..|....:.:.::|....|.      |.|:.|   |::.    .:|..:|::     .
Mouse   348 RAG-LFHGTELLCKTVVSSEISGKNDHIWNEQLEFDINICDLPRMARLCFAVYAVLDKVKTKKST 411

  Fly   963 EVLDP--YLTIRCRKSVDFSLKCLW---LLEAYNYQVDSLGNSHNSSRKSKLALMKEIFSKREHK 1022
            :.::|  |.|||....|.:.:  .|   ::..:..|:.| |:....|..|....::|:.:.....
Mouse   412 KTINPSKYQTIRKAGKVHYPV--AWVNTMVFDFKGQLRS-GDVILHSWSSFPDELEEMLNPMGTV 473

  Fly  1023 QTQNDLKSAGTGGLHVGEPRSVVALAKKTHHRSQSDATV-LLADFRSPHTLSISHRMYQQ-PPYT 1085
            ||....::|  ..||:..|.:    .|:..:....|..: ..|:..|..:.::|.|..:: ....
Mouse   474 QTNPYAENA--TALHITFPEN----KKQPCYYPPFDKIIEKAAELASGDSANVSSRGGKKFLAVL 532

  Fly  1086 TQTLPTTP-AKLCLGDLTSGHAFDNGCTCFETVRGQVNGLLGQRTLCSCGAPKTSPQKEFMKALM 1149
            .:.|...| ::||          :|......|:|..          |....|::.|     |.|:
Mouse   533 KEILDRDPLSQLC----------ENEMDLIWTLRQD----------CRENFPQSLP-----KLLL 572

  Fly  1150 NVGKNLTSWPSKAEKTSALRMSLNLINKNLPARVWLPLYS-DIPHHVVRITEEKTAV-----LNS 1208
            ::     .| :|.|..:.|:..|.:..| ||.|..|.|.. :.|...||    :.||     ::.
Mouse   573 SI-----KW-NKLEDVAQLQALLQIWPK-LPPREALELLDFNYPDQYVR----EYAVGCLRQMSD 626

  Fly  1209 KDKTPYII-YVEVVEIPDIYTSP----LIPKMMPSLR-------HTKSEEH-----------LDG 1250
            ::.:.|:: .|:|::........    |:.:.:.:.|       |.:||.|           |:.
Mouse   627 EELSQYLLQLVQVLKYEPFLDCALSRFLLERALDNRRIGQFLFWHLRSEVHTPAVSVQFGVILEA 691

  Fly  1251 SCLNSHQH----------LSCSRTSSCSSSQQGTSCRRKKGADVDGGCGDAGPHNSCSNVHSLGG 1305
            .|..|..|          |:..:|.:...........|.||.:                      
Mouse   692 YCRGSVGHMKVLSKQVEALNKLKTLNSLIKLNAVKLSRAKGKE---------------------- 734

  Fly  1306 LQFQEDDVWSQEEDEITAQYLNMRKVSERDTISQISLDSCDSRDQGPPVVFNIGDVRLRHC---S 1367
                             |.:..:::.:.|:.:|.:         |.|          |..|   |
Mouse   735 -----------------AMHTCLKQSAYREALSDL---------QSP----------LNPCVILS 763

  Fly  1368 NLSCENTKSFSNDPEDPSAAALKEPWHEKEKLIRESSPYGHLSNWRLLSAIVKCGDDLRQELMAT 1432
            .|..|..|...        :.:|..|     |:..|..:|..|    :..|.|.||||||:::..
Mouse   764 ELYVEKCKYMD--------SKMKPLW-----LVYSSRAFGEDS----VGVIFKNGDDLRQDMLTL 811

  Fly  1433 QLLQMFKIIWQEEQVDLWVRPYKIVCLSNDSGLIEPILNTVSLHQIKKNS---------NKSLKE 1488
            |:|::..::|:|..:||.:.||..:...:.|||||.:..:.::..|:.||         ||....
Mouse   812 QMLRLMDLLWKEAGLDLRMLPYGCLATGDRSGLIEVVSTSETIADIQLNSSNVAATAAFNKDALL 876

  Fly  1489 YFIDEYGSPSGESFRRAQKNFVQSCAAYCLISYLLQVKDRHNGNILFHSDGHIIHIDFGFILSIS 1553
            .::.||.  ||:...||.:.|..|||.||:.||:|.:.|||:.||:....|.:.|||||.||...
Mouse   877 NWLKEYN--SGDDLDRAIEEFTLSCAGYCVASYVLGIGDRHSDNIMVKKTGQLFHIDFGHILGNF 939

  Fly  1554 PKNLGF--EQSPFKLTPEFVEVM--GGT-SSEHWREFNKLLLVGMMSARKHMDRIINFVEIMRSN 1613
            ....|.  |:.||.||.:|:.|:  |.| ::|.:..|.:......:..|:|.:..|....:|.: 
Mouse   940 KSKFGIKRERVPFILTYDFIHVIQQGKTGNTEKFGRFRQCCEDAYLILRRHGNLFITLFALMLT- 1003

  Fly  1614 AHLP---CFKNGCSGTVQNLRKRFHMNLTEQEMERKVEQLVQDSLK-SLSTKL 1662
            |.||   ..|:     :|.|:....:..:|:|..::.:|...::|: |.:||:
Mouse  1004 AGLPELTSVKD-----IQYLKDSLALGKSEEEALKQFKQKFDEALRESWTTKV 1051

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fwdNP_001356971.1 PI4Kc_III_beta 1385..1674 CDD:270712 89/296 (30%)
Pik3cbNP_083370.2 PI3K_p85B 35..112 CDD:197539
PI3K_rbd 174..282 CDD:366310
C2_PI3K_class_I_beta_delta 318..495 CDD:176075 37/193 (19%)
Nuclear localization signal (NLS). /evidence=ECO:0000250 404..412 0/7 (0%)
PI3Ka_I 526..696 CDD:238444 39/205 (19%)
PI3Kc_IA_beta 700..1061 CDD:270717 105/435 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
21.900

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