DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fwd and Pik3c3

DIOPT Version :9

Sequence 1:	NP_001356971.1	Gene:	fwd / 45374	FlyBaseID:	FBgn0004373	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_075247.1	Gene:	Pik3c3 / 65052	RGDID:	620899	Length:	887	Species:	Rattus norvegicus

Alignment Length:	741	Identity:	159/741 - (21%)
Similarity:	280/741 - (37%)	Gaps:	198/741 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly  1045 VALAKKTHHRSQSDATVLLADFR---------------------SPHTLSISHRMYQQPPYTTQT 1088
            :.:..::..|| |:...|:.:||                     ||...|........|..:.:.
  Rat   201 IEMINESEKRS-SNFMYLMVEFRCVKCDDKEYGIVYYEKDGDESSPILTSFELVKVPDPQMSMEN 264

  Fly  1089 LPTTPAKLCLGDLTSGHAFDNGCTCFETVRGQVNGLLGQRTLCSCGAPKTSPQKE---------- 1143
            |..:........|.||.: |:......|.|.|:|.::..           .|.|:
  Rat   265 LVESKHHKLARSLRSGPS-DHDLKPNATTRDQLNIIVSY-----------PPTKQLTYEEQDLVW 317

  Fly  1144 -FMKALMNVGKNLT------SW--PSKAEKTSALRMSLNLINKNLPARVWLPLYSD-----IPHH 1194
             |...|.|..|.||      :|  |.:|      :.:|.|:.|      |.|:..:     :..|
  Rat   318 KFRYYLTNQEKALTKFLKCVNWDLPQEA------KQALELLGK------WKPMDVEDSLELLSSH 370

  Fly  1195 VVRITEEKTAV--LNSKDKTPYIIYVEVVEIPDIYTSPLIPKMMPSLRHTKSEEHLDGSCLNSHQ 1257
            ....|..:.||  |...|....::|              :.:::.:|::...::..:|
  Rat   371 YTNPTVRRYAVARLRQADDEDLLMY--------------LLQLVQALKYENFDDIKNG------- 414

  Fly  1258 HLSCSRTSSCSSSQQGTSCRRKKGADVDGGCGDAGP----------------------------- 1293
             |..::..|.:|..:..|......||:|.......|
  Rat   415 -LEPTKKDSQASVSESLSSSGVSSADIDSSQIITNPLPPVASPPPASKSKEVSDGENLEQDLCTF 478

  Fly  1294 --HNSCSNVHSLGGLQFQ-----EDDVWSQEEDEITAQYLN-MRKVSE------------RDTIS 1338
              ..:|.|......|.:.     ||....|.:.:....||| ||:.|:            |..::
  Rat   479 LISRACKNSTLANYLYWYVIVECEDQDTQQRDPKTHEMYLNVMRRFSQALLKGDKSVRVMRSLLA 543

  Fly  1339 Q--------ISLDSCDSRDQGPPVVFNIGDVRLRHCSNLSCENTKSFSNDPEDPSAAALK----- 1390
            .        :.|.....|:.|.           |...|   |..::...|.|..:.:.::
  Rat   544 AQQTFVDRLVHLMKAVQRESGN-----------RKKKN---ERLQALLGDNEKMNLSDVELIPLP 594

  Fly  1391 -EPWHEKEKLIRESSPYGHLSNWRLLSA--------------IVKCGDDLRQELMATQLLQMFKI 1440
             ||..:...:|.|::.   |....|:.|              |.|.||||||:.:..|::.:...
  Rat   595 LEPQVKIRGIIPETAT---LFKSALMPAQLFFKTEDGGKYPVIFKHGDDLRQDQLILQIISLMDK 656

  Fly  1441 IWQEEQVDLWVRPYKIVCLSNDSGLIEPILNTVSLHQI---KKNSNKSLKEYFIDEYGSPSGESF 1502
            :.::|.:||.:.|||::..|...|.:: .:.:|.:.::   :.:.....::|...|.| |:|.|
  Rat   657 LLRKENLDLKLTPYKVLATSTKHGFMQ-FIQSVPVAEVLDTEGSIQNFFRKYAPSETG-PNGIS- 718

  Fly  1503 RRAQKNFVQSCAAYCLISYLLQVKDRHNGNILFHSDGHIIHIDFGFILSISPKNLGFEQSPFKLT 1567
            ......:|:|||.||:|:|:|.|.|||..|:|....|.:.|||||:||...||.|   ..|.||.
  Rat   719 AEVMDTYVKSCAGYCVITYILGVGDRHLDNLLLTKTGKLFHIDFGYILGRDPKPL---PPPMKLN 780

  Fly  1568 PEFVEVMGGTSSEHWREFNKLLLVGMMSARKHMDRIINFVEIMRSNAHLPCFKNGCSGTVQNLRK 1632
            .|.||.||||.||.::||.|......:..|::.:.|:|...:| .:|::|........||:.::.
  Rat   781 KEMVEGMGGTQSEQYQEFRKQCYTAFLHLRRYSNLILNLFSLM-VDANIPDIALEPDKTVKKVQD 844

  Fly  1633 RFHMNLTEQEMERKVEQLVQDSLKSL 1658
            :|.::|:::|....::.|:.:|:.:|
  Rat   845 KFRLDLSDEEAVHYMQSLIDESVHAL 870

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	86/297 (29%)
Pik3c3	NP_075247.1	C2_PI3K_class_III	26..186	CDD:176042
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	149..170
		PI3Ka_III	283..503	CDD:238442	41/264 (16%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	416..467		7/50 (14%)
		PI3Kc_III	539..883	CDD:270628	95/356 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810