Protein Alignment fwd and Pi4ka

DIOPT Version :10

• Sequence 1: NP_001356971.1
• Gene: fwd / 45374
• FlyBaseID: FBgn0004373
• Length: 1682
• Species: Drosophila melanogaster
• Sequence 2: NP_001401943.1
• Gene: Pi4ka / 64161
• RGDID: 621213
• Length: 2114
• Species: Rattus norvegicus
• Alignment Length: 646
• Identity: 175/646 - (27%)
• Similarity: 284/646 - (43%)
• Gaps: 162/646 - (25%)

  Fly  1136 PKTSPQKEFMKALMNVGKN-LTSWPSK----AEKTSALRMSLNL-------INKNLPAR------ 1182
            |.::|:.|..:|    |:| :.:|.||    :||  ..:.::||       :...||||
  Rat  1521 PLSAPELELDQA----GENSVANWRSKYISLSEK--QWKDNVNLAWTISPYLAVQLPARFKNTEA 1579

  Fly  1183 ---------------------------VWLPLYSDIPH--HVV--RITEEKTAVLNSKDKTP--- 1213
                                       .|..:.:|.|.  ||:  ..|:..|.:.......|
  Rat  1580 IGNEVTRLVRLDPGAVSDVPEAIKFLVTWHTIDADAPELSHVLCWAPTDPPTGLSYFSSMYPPHP 1644

  Fly  1214 ----YIIYVEVVEIPD---IYTSPLIPKMMPSLRHTKS---EEHL----DGSCLNSHQHLSCSRT 1264
                |.:.|.....||   .|    ||:::.:||:.|.   .|::    ..|.|.:||.:...:|
  Rat  1645 LTAQYGVKVLRSFPPDAILFY----IPQIVQALRYDKMGYVREYILWAAAKSQLLAHQFIWNMKT 1705

  Fly  1265 SSCSSSQQGTSCRRKKGADVDGGCGDAGPHNSCSNVHSLGGLQFQEDDVWSQEEDEITAQYLNMR 1329
             :....::|    .:|..|:                          .|:..|..:|||.......
  Rat  1706 -NIYLDEEG----HQKDPDI--------------------------GDLLEQLVEEITGSLSGPA 1739

  Fly  1330 K---VSERDTISQISLDSCDSRDQGPPVVFNIGDVRLRHC----SNLSCENTKSFSNDPE----- 1382
            |   ..|.|..::|:..|...:.      :..||.|.:.|    |.:..:......::||
  Rat  1740 KDFYQREFDFFNKITNVSAIIKP------YPKGDERKKACLSALSEVKVQPGCYLPSNPEAIVLD 1798

  Fly  1383 ------DPSAAALKEPW-------------HEKEKL---------IRESSPYGHLSNWRLLSAIV 1419
                  .|..:|.|.|:             .|||.|         .|.....|....|:  :||.
  Rat  1799 IDYKSGTPMQSAAKAPYLAKFKVKRCGVSELEKEGLQCRSDTEDECRRQEADGKKICWQ--AAIF 1861

  Fly  1420 KCGDDLRQELMATQLLQMFKIIWQEEQVDLWVRPYKIVCLSNDSGLIEPILNTVSLHQIKKNSNK 1484
            |.|||.||:::|.|::.:||.|:|...:||:|.||::|..:...|:||.|.:..|..|:.:.::.
  Rat  1862 KVGDDCRQDMLALQIIDLFKNIFQLVGLDLFVFPYRVVATAPGCGVIECIPDCTSRDQLGRQTDF 1926

  Fly  1485 SLKEYFIDEYGSPSGESFRRAQKNFVQSCAAYCLISYLLQVKDRHNGNILFHSDGHIIHIDFGFI 1549
            .:.:||..:||..|..:|::|:.||::|.|||.|:.:|||:||||||||:....||||||||||:
  Rat  1927 GMYDYFTRQYGDESTLAFQQARYNFIRSMAAYSLLLFLLQIKDRHNGNIMLDKKGHIIHIDFGFM 1991

  Fly  1550 LSISP-KNLGFEQSPFKLTPEFVEVMGG-TSSEHWREFNKLLLVGMMSARKHMDRIINFVEIMRS 1612
            ...|| .|||:|.. .|||.|.|.:||| ..:..::.|.::.:.|.::.|.:||.:::.|.:|..
  Rat  1992 FESSPGGNLGWEPD-IKLTDEMVMIMGGKMEATPFKWFMEMCVRGYLAVRPYMDAVVSLVTLMLD 2055

  Fly  1613 NAHLPCFKNGCSGTVQNLRKRFHMNLTEQEMERKVEQLVQDSLKSLSTKLYDGYQYYTNGI 1673
            .. ||||:   ..|::.|:.||..|:||:|....:.:::|:...|..::.||..|||.|.|
  Rat  2056 TG-LPCFR---GQTIKLLKHRFSPNMTEREAANFIMKIIQNCFLSNRSRTYDMIQYYQNDI 2112

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	113/313 (36%)
Pi4ka	NP_001401943.1	PI4K_N	390..1526	CDD:437106	1/4 (25%)
		PI4Ka	1559..1734	CDD:238443	36/209 (17%)
		PI4Kc_III_alpha	1795..2113	CDD:270711	114/325 (35%)