DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fwd and smg1

DIOPT Version :9

Sequence 1:NP_001356971.1 Gene:fwd / 45374 FlyBaseID:FBgn0004373 Length:1682 Species:Drosophila melanogaster
Sequence 2:XP_009297728.1 Gene:smg1 / 569810 ZFINID:ZDB-GENE-061013-767 Length:3641 Species:Danio rerio


Alignment Length:2049 Identity:374/2049 - (18%)
Similarity:627/2049 - (30%) Gaps:716/2049 - (34%)


- Green bases have known domain annotations that are detailed below.


  Fly     1 MNSVISAFKGKKNSNPSCNSPMGSANGTAPVEAKPNNCYQYLRHIREI----DTNNKL-----LS 56
            :||::|.. |..::.|....|..|....:|..|:    :..:.::..:    :|.|.|     ||
Zfish   567 LNSLLSPL-GLPDACPHIQHPAFSQLNFSPERAE----FVLIFNLSALTTIGNTKNSLIGMWALS 626

  Fly    57 PVVVVAEERPVSKAGSPSTVATMATGVDVV----DHCLPTTVRLSVTEALSDLNMNGKAVEPPVT 117
            |.|.....:.:....|...|...|....|:    .||......:|.:.:.|..::...||...||
Zfish   627 PTVFALLSQNLVIVHSDLAVHHPAVQYAVLYTLYSHCTRHDHFISSSLSSSSPSLFDGAVISTVT 691

  Fly   118 PCTS---------VG-----DNAN-----------LEVA------ETWA-----------CPPPQ 140
            ..|.         :|     |:.|           ||||      ||:|           |....
Zfish   692 TATKRHFSTLLNLLGMLLSKDHLNPEARRLLLTWSLEVALMMKKSETYAPLFSLPSFLKFCKGLL 756

  Fly   141 ATD-DEDISEHSTAACTSTSSSSEHSNSTVVHSPTVGESTCDSVSVSVSHPSPSVSQNNTSSATG 204
            |.. :||     |..|....:|.:..:|::  :..:.:...|...|.:.|.:..|.|     |.|
Zfish   757 ANSLNED-----TTICLQACNSLQVLSSSL--TMELLQRCVDVCRVQLVHSAVRVRQ-----AFG 809

  Fly   205 R----------MSSPHSQS---SLSIACEPHSA---STT----------------TLSSLGSD-- 235
            :          :||.||.|   .:|:|...|.:   |.|                |:...|.:  
Zfish   810 KLLRSVPMHVALSSAHSHSEIKEISLAIRRHMSKVPSNTFHPQDFSDLIGFILYGTVHRGGKEPW 874

  Fly   236 ----------LGNGNGSTVPAFLM-------------AAPVTL------PIGGQMPTIKCLPG-- 269
                      |...:.:.||..|:             ||..|:      |:|....|.:.:.|  
Zfish   875 LERLYHSCQRLEKKDSAMVPRALLKTEAVLWQWAVWEAAQFTVLSKLRTPLGRAQDTFQTIEGMI 939

  Fly   270 ----ASSAASTPKHSRYS-----------KPRLSLSRVFNHSMPSVHGRPNLSLAPAGVPGSVN- 318
                |.|..:..:.|::|           :.||:|...|..::..:     :..|..|...::. 
Zfish   940 RSLAAHSLNTEQELSQWSGGESDEGHHTNQLRLALLLQFLENLEKL-----MYNAYEGCASALTA 999

  Fly   319 PPKRISTH-----------QRNLSLDFRSMGILLPPVSQVTNNHINHTQHHRNRSLDSALQRIPE 372
            |||.|.|.           ...:.|....:|:|....:....:..:.....:|.|...     ||
Zfish  1000 PPKGIRTFFYTNRQTCQDWLTRIRLALMRVGLLSGQPAVTVRHGFDLLTEIKNSSTQG-----PE 1059

  Fly   373 VEV------------------------------------SSPNAESENTF--------------- 386
            :||                                    ||...::|..|               
Zfish  1060 MEVPVTMLVEALCELRCPEAIQGLAAWSLANTGKSMGWLSSVALQAEGKFEKAALEYQEQLCAVT 1124

  Fly   387 ---CSPSILGATMCSKIATTAATVTSALSPPGTPTPALMSTACTPTIGAVKGNVQHPVPKHEQSI 448
               ||..:...::.....|..::.....|..|..|..|.|:.|:|.:.....|            
Zfish  1125 GMDCSIKVFDRSLLKLTGTNTSSPKHTSSGEGRKTVLLKSSECSPEVLNFLAN------------ 1177

  Fly   449 SLAAACRSSAVVESCPTLRMRPKSSESVAANGQEMIGVIVSSTGNGSSSSNN-----------SC 502
               .||.....:...          |||    ||....:::...|.||||.|           |.
Zfish  1178 ---KACECYVALSDW----------ESV----QEWQASMMNLKKNSSSSSVNLKTDFNYIRAMSR 1225

  Fly   503 SSAGS-TKKREDLTSLGSDDSGIICGSESDQISLNRICHSHESLDSGEMDADADAE--EECVDLM 564
            ...|. |:.|..|..|..||.|::..:..|:|.|.|:..:..|.|..|:....:.:  ...|..:
Zfish  1226 FEEGDFTECRAQLELLPGDDYGLLNSTTKDKIDLKRLLPAVLSPDPSELQKAIEVQLLRSAVGAI 1290

  Fly   565 DTTSIDEEYNIMQPDHLCLYPPQAASTELDCRTLRPSRKQKRQQQQVLERKNLPSQNQIESEDSV 629
            ..|:.:::..:...|.|..|..|.....|.  .||.|..........|....|...|.:|:    
Zfish  1291 SATNHEQDQKVASSDTLVKYLKQTGRICLG--PLRLSTLTLSDSLPTLSTLQLHCANSLEN---- 1349

  Fly   630 DAGVDARTRYRVMNMSQAAINVELGTASNEIDPDVNYRESHQDPIADAPSLSTPSVASTASATPS 694
                                                                     |..:..|.
Zfish  1350 ---------------------------------------------------------SLCNQHPE 1357

  Fly   695 VTPTPIATPTPTESTKND----------QVLFKNFFGATKNAIFRTAQSIIENH-------EKKN 742
            ....|:.:...|...:.|          ....:.||...|.     :.|.:::|       ..|.
Zfish  1358 DCLIPLFSEALTTCKQQDVQPWLHALRYTTFQREFFQKLKG-----SSSPVDSHLMELCLTAVKF 1417

  Fly   743 AAKQKEQPDHSGTVSLVGSPNGGSSVPQDLVKS----------------PTDISKKKEFFSLLTS 791
            |.||......:..:||...|....:..||||:|                ..:|.|.|..|:...|
Zfish  1418 ARKQGNIALATRLLSLCSKPAMSDTEGQDLVQSFRQLSLEGTVGEKWGPELEIEKAKVLFAAGQS 1482

  Fly   792 SSSIKAAAAAAANSAASTPPATPTEALAANSNSKLQP--LSD-----PSADLKVKERTLNLRLPG 849
            .|:::..::.|.:...|    ...|..|..|...|..  |:|     |...:.||:         
Zfish  1483 VSAMEMLSSCALSYCHS----GKCELAACRSVLTLCKWLLADWKDLTPQLKMVVKK--------- 1534

  Fly   850 DSEGSEGALTKCSSINSIHKLKLPVPGVVKYFISEKAPVSDVLQKPE--KGQSGLLRFFESP-VF 911
             :.||....|...:|:.:  |:||:.......|:.:..||..:.:|:  .||...|...::| |.
Zfish  1535 -NSGSTSLSTLSKNISGL--LELPLEDQGMPHITTETTVSVGVGEPDFVLGQLYQLSTTQAPEVA 1596

  Fly   912 NIHFAVHYLFY----------SKEPGVLSFIGNKIFSFPDQEVDLYIPQLVVMYIQMDELAEVLD 966
            ....|:....|          |:..||...:|.|      :|::..:|...     .||..|.:.
Zfish  1597 KSWAALASWAYRWGRKVVDNASQGEGVPLLLGEK------KEIEELLPAGT-----SDEDKETIF 1650

  Fly   967 PYL-TIRCR----KSVDFSLK--------------------CLW-----------LLEAYNYQVD 995
            ..| ...||    :..|.:|:                    |.|           |:..:...||
Zfish  1651 GILGQAMCRPAGIQDEDMALQNEEDDEDDMVDVIGRQLLGACPWLSDVEDTVTDGLIGVWRRVVD 1715

  Fly   996 SLGNSHNSSRKSKLALM--------------KEIFSKREHKQTQNDLKSAGTGGL------HVGE 1040
            .:.:.:..|.::....:              |.:.:.:..||:.:|:....|..|      |.||
Zfish  1716 RIFSLYRVSCRAYFTFLKLNAGQVPIDEDDPKLLLNNQNSKQSSDDVIVMATLRLLRLLVKHAGE 1780

  Fly  1041 PRSVVALAKKTHHRSQSDATV--------LLADFRSPHT------LSISHRMYQQPPYTTQTLPT 1091
                  |.:...|...|..|.        |.:....|..      .|:..|:.|..|:.. ..|.
Zfish  1781 ------LREGLEHGLASTPTAPWRGIIPQLFSRLNHPEAYIRQSICSLLCRVAQDSPHLI-LYPA 1838

  Fly  1092 TPAKLCLGD--LTSGHAFDNGC-TCFETVRGQVNGLLGQRTLCSCGAPKTSPQ-----------K 1142
            ....:.||.  .|:|:...:.. |....::|:  ||.|..:  ..|:..||.:           .
Zfish  1839 IVGSISLGGEAQTAGNKLPSSLPTLLGNMQGE--GLCGGES--ETGSGPTSQESSRGEEMVMYSS 1899

  Fly  1143 EFMKALMNVGKNLTSWPSKAEKTSALRMSLNLINK-----NLPARVWLPLYSDIPHHVVR----I 1198
            |....:.:....:....|.|..|..|::.: |:.:     .|...:||.:......||:|    :
Zfish  1900 EDQAMMQDCYSKIVDKLSSANPTMVLQVQM-LVGELRRVTLLWDELWLGVLQQQHMHVLRRIQQL 1963

  Fly  1199 TEEKTAVLNS----KDKTPYIIYVEVVEIPDIYTSPLIPKMMPSLRHTKS----------EEHLD 1249
            .:|...|.|:    ||        |.|.|.....|.|:..::.:|.|.:|          ||...
Zfish  1964 EDEVKRVQNNNTLRKD--------EKVAIMREKHSALMKPVVFALDHVRSITAAPAETPHEEWFQ 2020

  Fly  1250 ---GSCLNSHQHLSCSRTSSCSSSQQGTSCRRKKGADVDGGCGDAGPHNSCSNVHSLGGLQFQED 1311
               |..:    |.:..|..|                       ...|.|..|:     .:.|::.
Zfish  2021 ETYGDAI----HNALERLRS-----------------------PLNPANPASS-----WVPFKQI 2053

  Fly  1312 DVWSQEEDEITAQYLNMR--------------------KVSERDTISQISLDS------------ 1344
            .:..|:..:..|.|| :|                    :||..|.::..|:.:            
Zfish  2054 MLSLQQRAQKRASYL-LRLDEISPRLTAMANTEMALPGEVSATDAVTIQSVGNTITILPTKTKPK 2117

  Fly  1345 ------CDSRDQGPPVVF-NIGDVRL--RHCSNLSCENTKSFS--NDPEDPSAAALKEPWHEKEK 1398
                  .|.|:.  |.:| .:.|:.|  |....||..|| .|:  |..|.|...|          
Zfish  2118 KLYFLGSDGRNY--PYLFKGLEDLHLDERIMQFLSIVNT-MFTKVNQQESPRFQA---------- 2169

  Fly  1399 LIRESS--PYGHLSNWRLLSAIVKCGDDLRQELMATQLLQMFKIIWQEEQV--------DLWVRP 1453
              |..|  |.|      ..|.:::..|.      ||.|..::| .||:.:.        |.:.:|
Zfish  2170 --RHYSVTPLG------TRSGLIQWVDG------ATPLFGLYK-RWQQREAVVQAQKAQDSFQQP 2219

  Fly  1454 YKIVCLSNDSGL----IEPILNTVSLH----------QIKKNSNKSLKEYFIDEYGSP------- 1497
            ..:..:...|.|    |.|.|..|.|.          .:.::..:.|.|      .:|       
Zfish  2220 QNLPMVPRPSELYYSKISPALKAVGLSLDVSRRDWPLSVMRDVLRELME------ATPPNLLAKE 2278

  Fly  1498 ------SGESFRRAQKNFVQSCAAYCLISYLLQVKDRHNGNILFH-SDGHIIHIDFGFILSISPK 1555
                  :...:....:.:.:|.|...::.|::.:.|||..|:|.. :.|.::|||:         
Zfish  2279 LWCSCTTPSEWWSVTQTYARSTAVMSMVGYIIGLGDRHLDNVLIDMTTGEVVHIDY--------- 2334

  Fly  1556 NLGFEQS---------PFKLTPEFVEVMGGTSSE 1580
            |:.||:.         ||::|......:|.|..|
Zfish  2335 NVCFEKGKSLRVPEKVPFRMTHNIETALGVTGVE 2368

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fwdNP_001356971.1 PI4Kc_III_beta 1385..1674 CDD:270712 46/243 (19%)
smg1XP_009297728.1 HEAT repeat 143..173 CDD:293787
HEAT repeat 183..216 CDD:293787
HEAT repeat 223..254 CDD:293787
SMG1 622..1231 CDD:292413 119/659 (18%)
PIKKc_SMG1 2100..2406 CDD:270714 62/312 (20%)
FATC 3611..3640 CDD:280430
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.900

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