DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fwd and pik3c2b

DIOPT Version :9

Sequence 1:	NP_001356971.1	Gene:	fwd / 45374	FlyBaseID:	FBgn0004373	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	XP_003199535.1	Gene:	pik3c2b / 567938	ZFINID:	ZDB-GENE-050309-145	Length:	1587	Species:	Danio rerio

Alignment Length:	1406	Identity:	263/1406 - (18%)
Similarity:	475/1406 - (33%)	Gaps:	433/1406 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   588 AASTELDCRTLRPSRKQKRQQQQVLERKNLPSQNQIESEDSVDAGVDARTRYRVMNMSQAAINVE 652
            ||.|:.|          :.|:...||...| ||.::...:::....||..|:|          .:
Zfish     3 AAQTQND----------REQRWGCLESLGL-SQKELVLAEALQMEYDALARHR----------QD 46

  Fly   653 LGTASNEIDPDVNYRESHQDPIADAPSLSTPSVASTASATPSVTPTPIATPTPTESTKNDQVLFK 717
            .||:|. :.||              .|.|:||  .:.|:.|...|:|.......:.......:..
Zfish    47 KGTSST-LPPD--------------SSKSSPS--RSESSLPRRVPSPSWNNLQQQGVSGSDPMLN 94

  Fly   718 NFFGATKNAIFRTAQSIIENH---EKKNAAKQKEQPDHSGTVSLV--GSPN-------------- 763
            :    .:..:...::|..|:|   ::......:.:.|..||..::  |.|.
Zfish    95 H----VQPGVSNLSRSSGESHGFTKEPRYILDEWESDFKGTSQMLSKGLPTLDEPPPPVPPRNPI 155

  Fly   764 --------GGSSVPQDLVKSPTDISKKKEFF-------SLLTSSSSIKA---------------A 798
                    ..||.|:|:.....::.:.|..|       :|..|.|.|..               :
Zfish   156 PQNDPFIVHRSSAPRDVNLFTPEVDQPKLSFGETLNYDNLNDSLSKINGDWLSPGRSRRANGDKS 220

  Fly   799 AAAAANSAASTPPATPTEALAANSNSKLQPLSDPSADLKVKERTLNLRLPG--------DSEGSE 855
            ..|.|.|....|...|...|....:::.|      ..:.|...:|..|..|        ..|..|
Zfish   221 GKAVARSNTLPPQIPPRTYLPTPKSTRSQ------RRVSVDPVSLGSRPNGFGYELFQVSEERDE 279

  Fly   856 GALTKCSSINSIHKLKLPVPGVVKYFISEKAPVSDVLQKP----EKGQSGLLRFFESPVFNIHFA 916
            .....|..::.:..         .|..::.:..|..:..|    ::.|.||....:..|::.||
Zfish   280 EVAAFCHVLDLLRS---------AYPCNDYSKNSGFVWSPCVAQDELQQGLGVSIKVTVYSDHF- 334

  Fly   917 VHYLFYSKEPGVLSFIGNKIFSFPDQEVDLYIPQLVVMYIQMDELAEV-LDPYLTIRCRK----- 975
                   :||...|..|:       ..:||.|.| .:.|.. |:|..: :|.||...|.:
Zfish   335 -------REPLTFSCDGS-------STIDLLIYQ-TLCYAH-DDLDMIDVDDYLLKICSQAEFLK 383

  Fly   976 ------SVDFSLKCL---WLLE-------------AYNYQVDSLGNSHNSS------------RK 1006
                  |.::..:||   |.:.             |...:.|...::.|.|            .|
Zfish   384 NTQTLASFEYIQQCLKFDWDIRLILTKRSSVNMELARTTEDDDTPSTMNHSILLQERPIKQTVTK 448

  Fly  1007 SKLALMKEIFSKREHKQTQNDLKSAGTGGLHVG-------------------------------- 1039
            ..|.|:.:.|    |.:.::.|.|.....|||.
Zfish   449 EALTLLLDTF----HNEAESFLLSEVELPLHVERLVQSVKALCTSLAAVETPDITAALNQLPACP 509

  Fly  1040 ---EP---RSVVALAKKTH-------------------------------HRSQSDATV------ 1061
               :|   :.|..||||.:                               |.|:|.|.:
Zfish   510 CRLQPKVQKDVSVLAKKENRVAIVEKLTAAILDLVELYCSTFNANFHTMPHSSRSTAPIQEAGMV 574

  Fly  1062 -------LLADFRSPHTLSISHRMYQQPPYTTQTLPTTPAKLCLGDLTSGHAFD---------NG 1110
                   :.|..|.|.|.:.|:..:    :.:.:|.....:||....||..:..         :.
Zfish   575 TNVLSFSVYAAHRVPITWAASYENF----FLSCSLTHGGVELCAPQHTSKQSVSKYLFHLVVWDQ 635

  Fly  1111 CTCFETVRGQVNGLLGQRTLCSC----------GAPKTSPQKEFMKAL-------------MNVG 1152
            ..||..   |:|.|..:..|...          ||.:.|.||..:::|             :..|
Zfish   636 RVCFPV---QINQLPRESQLTVTLYATPLPPPGGAEEKSKQKRSIESLGWVTMPLFNFRHVLTCG 697

  Fly  1153 KNLTS-WPSKAEKTSALRMSLNLINKNLPARVWLPLYSDIP----------------------HH 1194
            :.|.. |||.....:|...:.|.   :.|..|.|.:  |.|                      .|
Zfish   698 RKLLGLWPSTPGSGNARSSTPNF---SQPDSVILQV--DFPTSSFEVRFSTPAPAEFSPQYEFSH 757

  Fly  1195 VVRITEEKT-AVLNSKD-------------KTPYIIYVEVVEIPDIYTS------PLIPKMMPSL 1239
            :.::::.:. .||:.|.             :..|..:||...:|.:..|      ..:|.:...|
Zfish   758 LDQVSQRQLHDVLHKKSLFWLSPEDRRLLWEKRYFCHVEASRLPLVLASAPSWEWACLPDIYALL 822

  Fly  1240 RHTKSEEHLDG-SCLN-SHQHLSCSRTSSCSSSQQGTSCRRKKGADVDGGCGDAGPHNSCSNVH- 1301
            |......|||. ..|| :.....|.||    :.|...|....:..|.......|..:....:.|
Zfish   823 RQWGCMNHLDALGLLNATFPDQECRRT----AVQWMDSISDPELLDFLPQLVQALKYECYLDSHL 883

  Fly  1302 -------SLGGLQFQE------DDVWSQEEDEITAQYL----------NMRKVSER-----DTIS 1338
                   ::|.::...      .|.....:..:..|||          .:|:..:|     :.::
Zfish   884 VRFLLRRAIGDVRIAHYLFWLLKDTLQDSQFSVRYQYLLAALLCCSGRGLREEFDRQCWLVNVLA 948

  Fly  1339 QISLDSCDSRDQGPPVVFNIG--DVRLRHCSNLSCE------------NTKSFSNDPEDPSAAAL 1389
            :::....::.......:...|  ||:.....|.||.            |.:|.|.  .:.:|..|
Zfish   949 KVAQRVREASPSSRQAILREGLDDVKQFFSINSSCRLPLNPGLLVKGINIQSCSY--FNSNAVPL 1011

  Fly  1390 KEPWHEKEKLIRESSPYGHLSNWRLLSAIVKCGDDLRQELMATQLLQMFKIIWQEEQVDLWVRPY 1454
            |..:..::          ||.:  .::.|.|.||||||:::..|::::...||.:|.:|:.:..:
Zfish  1012 KLSFQNQD----------HLGD--NINVIFKAGDDLRQDMLTLQIIRIMNKIWVQEGLDMRMVIF 1064

  Fly  1455 KIVCLSNDSGLIE--PILNTVSLHQIKKNSNKSLKEYFIDEY---GSPSGESFRRAQKNFVQSCA 1514
            :........|::|  |...|:...|::.....|.|:..:.::   .:|:.|.:.:|.:||:.|||
Zfish  1065 RCFSTGRGRGMVEMIPSAETLRKIQVEHGVTGSFKDRPLADWLQKHNPTEEEYEKAVENFIYSCA 1129

  Fly  1515 AYCLISYLLQVKDRHNGNILFHSDGHIIHIDFGFILSISPK--NLGFEQSPFKLTPEFVEVMGG- 1576
            ..|:.:|:|.:.||||.||:..:.||:.|||||..|..:..  |:..:::||..|.:...|:.|
Zfish  1130 GCCVATYILGICDRHNDNIMLKTSGHMFHIDFGKFLGHAQMFGNIKRDRAPFVFTSDMAYVINGG 1194

  Fly  1577 -TSSEHWREFNKLLLVGMMSARKHMDRIINFVEIMRSNAHLPCFKNGCSGTVQNLR---KRFHMN 1637
             ..|..:.:|..|........|||....:|.:.:|.|:. :|...:     |.:|:   .....:
Zfish  1195 DKPSSRFHDFVDLCCEAYNRIRKHAHLFLNLLGLMLSSG-IPELSD-----VDDLKYVYDALRPH 1253

  Fly  1638 LTEQEMERKVEQLVQDSLKSLSTKLYDGYQYYTNGILXERF 1678
            .:|.:......:|::.||.|::|||    .::.:.:. .:|
Zfish  1254 ESEADATMHFTRLIESSLGSVATKL----NFFIHNLAQMKF 1290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	76/300 (25%)
pik3c2b	XP_003199535.1	PI3K_rbd	322..413	CDD:295323	22/107 (21%)
		C2A_PI3K_class_II	569..741	CDD:175979	34/183 (19%)
		PI3Ka	763..928	CDD:294194	29/168 (17%)
		PI3Kc_C2_beta	934..1287	CDD:119421	87/376 (23%)
		PX_domain	1317..1425	CDD:295365
		C2B_PI3K_class_II	1458..1579	CDD:176027
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810