DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fwd and si:rp71-17i16.5

DIOPT Version :9

Sequence 1:	NP_001356971.1	Gene:	fwd / 45374	FlyBaseID:	FBgn0004373	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	XP_021329311.1	Gene:	si:rp71-17i16.5 / 564261	ZFINID:	ZDB-GENE-090312-117	Length:	1069	Species:	Danio rerio

Alignment Length:	1086	Identity:	229/1086 - (21%)
Similarity:	386/1086 - (35%)	Gaps:	330/1086 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   696 TPTPIATPTPTESTKNDQVLFKNFFGATKNAIFRTAQSIIENHEKKNAAKQKEQPDHSG----TV 756
            |....|||...|..|.|.:.:     ||:.   .|...::.|             |..|    |:
Zfish   161 TRRKFATPRTQELKKRDLIAY-----ATEP---WTTSIVLPN-------------DQQGYFQRTL 204

  Fly   757 SLVGSPNGGS-SVPQDLVKSPTDISKKKEFFSLLTSSSSIKAAAAAAANSAASTPPATPTEALAA 820
            |:....||.: |:..||.:.|:||  .|.|:..|...|                   .|.|:..:
Zfish   205 SVTLYYNGSNLSIKADLTQKPSDI--LKIFWESLPKGS-------------------LPIESWTS 248

  Fly   821 NSNSKLQPLSD-PSADLKVK---------ERTLNLR--------LPGDSEGSE-----GALTKCS 862
            :...|:....: .|.|.::.         :.:|.|.        ||.|:..:|     .:||..|
Zfish   249 DHVLKVCGREEFLSGDFQLSNYLWVRHCLKNSLELHLSVVAISSLPDDTVSTEYWPLVDSLTGLS 313

  Fly   863 SINSIHKLKLPVPGVVKYFISEKAPVSDVLQKPEKGQSGLLRFFESPVFNIHFAVHYLFYSKEPG 927
            |.:....||             |..|.|::         |:..::.   ...|.|
Zfish   314 SSHEELCLK-------------KKEVEDIV---------LISLWDC---ERKFRV---------- 343

  Fly   928 VLSFIGNKIFSFPDQEVDLYIPQLVVMYIQMDELAEVLDPYLTIR--CRKSVDFSLKCLW----- 985
                   |:..|...::...:|.||  |::    |.::....||.  |....:|:.:.||
Zfish   344 -------KLLGFDIPDLPSKVPSLV--YVE----ATIIYGKKTISSICSTPKEFTDEVLWNTWLE 395

  Fly   986 --LLEAYNYQVDSLGNSHNSSRKSKLALMKEIFSKREHKQTQNDLKSAGTGGLHVGEPRSVVALA 1048
              :|.....|...||.:.|::..:|           |.|.:.:.:..
Zfish   396 FDILIRDIPQGAKLGLTINATEAAK-----------ETKSSSSKVPD------------------ 431

  Fly  1049 KKTHHRSQSD----ATVLLADFRS-----PHTLSI--------SHRMYQQPPYTTQTLPTTPAKL 1096
               ||:.:..    ..:.|.|.||     ||||::        ....|:....:|.|.|.....:
Zfish   432 ---HHKGKLQVLYFVNLQLIDHRSLLSQGPHTLNMWPFPEWDEEAVTYEADKLSTATNPDVANSM 493

  Fly  1097 CLGDLTSGHAF----DNGCTCFETVRGQVNGLLGQRTLCSCGAPKTSPQKEFMKALMNVGKNLTS 1157
            .:..:...::|    .|                |:.:.||    .|||..| ..:|...|::..|
Zfish   494 AITFMLDRYSFPVVLPN----------------GRSSSCS----GTSPVSE-SSSLDLAGESRLS 537

  Fly  1158 WP-SKAEKTSALRMSLNL--------------------INKNLPARV---------WLPL----- 1187
            .| |:|..|:.|....||                    :|..||..|         |.|.
Zfish   538 APFSEASSTATLTRMRNLKKFKEESVHYVSNLPQFLRTVNWMLPTVVQEVHWLLSHWGPEDIELF 602

  Fly  1188 ---------YSDIPHHVVRITEEKTAVLNSKDKTPYII-YVEVVEIPDIYTSPLIPKMMPSLRHT 1242
                     ::|:  .|.|:..::..:|::.:...|:: .|:.:::...:.|.|...::.....:
Zfish   603 VALELLSVDFADL--KVRRLAVQRLEILSNDEVLKYLLQLVQTLKVEPYHDSFLARFLLKRALRS 665

  Fly  1243 KSEEHLDGSCLNSHQHLSCSRTSSCSSSQQGTSCRRKKGADVDG---GCGDAGPHNSCSNVHSLG 1304
            |...|.....|.       |..:.|      ...|::....::.   |||:|          .|.
Zfish   666 KRIGHFFFWYLR-------SEVAGC------PFFRQRMAVILEAYLLGCGEA----------MLA 707

  Fly  1305 GLQFQEDDVWSQEEDEITAQYLNMRKVSERDTIS---QISLDSCD--SRDQGP--PVVFNIGDVR 1362
            ..|.|...|....:..:..:.|...:.....|..   |..|:.||  |..|.|  |.| ..|.:.
Zfish   708 EFQSQVQVVSYLHDVALAVKLLYPDRTDLPSTAPQKLQELLEKCDLPSDFQVPFDPRV-RAGSII 771

  Fly  1363 LRHCSNLSCENTKSFSNDPEDPSAAALKEP-WHEKEKLIRE---SSPYGHLSNWRLLSAIVKCGD 1423
            |:.|..:                 |:.|:| |.|...:..|   |.|.|         .|.|.||
Zfish   772 LKDCKIM-----------------ASKKKPLWLEFSCIQSEAPPSPPVG---------IIFKHGD 810

  Fly  1424 DLRQELMATQLLQMFKIIWQEEQVDLWVRPYKIVCLSNDSGLIEPILNTVSLHQIKKN------- 1481
            ||||:::..|.|.:...||||:.:||.:.||..:....:.|:||.:.|.:::..::::
Zfish   811 DLRQDMLIIQTLVVMDSIWQEKGLDLNLVPYGCISTGFNIGMIEIVRNAITIASVQRSQGGVAGA 875

  Fly  1482 -SNKSLKEYFIDEYGSPSGESFRRAQKNFVQSCAAYCLISYLLQVKDRHNGNILFHSDGHIIHID 1545
             .|.:|.::.  :...|..|...:|.:.||.|||.||:.:|:|.:.||||.||:....|::.|||
Zfish   876 FKNNALYDWL--QTKCPFQEKHFQATEKFVNSCAGYCVATYVLGIGDRHNDNIMITDQGNLFHID 938

  Fly  1546 FGFILSISPKNLGF--EQSPFKLTPEFVEVMG---GTSSEHWREFNKLLLVGMMSARKHMDRIIN 1605
            ||.||..:....|.  |:.||.|||:|:.|||   |..|.:::.|....:...:|.|.....::.
Zfish   939 FGHILGNTKSFWGVNRERVPFVLTPDFLYVMGRVKGRPSLYFQRFRDTCINAYLSLRAQSRLLVT 1003

  Fly  1606 FVEIMRSNAHLPCFKNGCSGTVQNLRKRFHMNLTEQEMERKVEQLV 1651
            ...:|.... :|  :...|..:..||.....:.:|:|....:.|.:
Zfish  1004 LFSLMLLTG-IP--ELSMSQDMLYLRTALQQDQSEEEARNHLLQQI 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	83/284 (29%)
si:rp71-17i16.5	XP_021329311.1	PI3K_rbd	189..292	CDD:321949	24/136 (18%)
		C2	332..506	CDD:326325	38/231 (16%)
		PI3Ka	557..702	CDD:320871	21/159 (13%)
		PI3Kc_IB_gamma	706..1069	CDD:270627	101/373 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900