DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fwd and pik3ca

DIOPT Version :9

Sequence 1:	NP_001356971.1	Gene:	fwd / 45374	FlyBaseID:	FBgn0004373	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	XP_009304451.1	Gene:	pik3ca / 561737	ZFINID:	ZDB-GENE-130409-1	Length:	1069	Species:	Danio rerio

Alignment Length:	916	Identity:	190/916 - (20%)
Similarity:	316/916 - (34%)	Gaps:	334/916 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly   816 EALAANSNSKLQPLSDPSADLKVKERTLNLRLPGDSEGSEGALTKCS-----------------S 863
            |.|..|.|::..|.|:|..:   :..|.::.:|.....:...|:.||                 :
Zfish   365 EQLCDNVNTQRVPCSNPRWN---EWLTYDMYIPDIPRAARLCLSICSVKGRKGAKEEHCPLAWGN 426

  Fly   864 INSIH--------KLKL---PVPGVVKYFISEKAPVSDVLQKPEKGQSGLLRFFESPVFNIHFAV 917
            :|...        |:.|   |||..::..::   |:......|.|         |:|...:.|.
Zfish   427 VNLFDYTHTLVSGKMALNLWPVPHGLEDLLN---PIGVTGSNPNK---------ETPCLELEFD- 478

  Fly   918 HYLFYSKEPGVLSFIGNKIFSFPDQEVDLYIPQLVVMYIQMDELAEVLDPYLTIRCRKSVDFSLK 982
                |...|          ..|||                   :|.:.|               .
Zfish   479 ----YFSSP----------VKFPD-------------------MATIED---------------H 495

  Fly   983 CLWLLE---AYNYQVDSLGNSHNSSRKSKLALMKEIFSKREHKQTQNDLKSAGTGGLHVGEPRSV 1044
            ..|::.   .|||        ..|.:.|::|        |:|..|:.|::.....|..  :|.|.
Zfish   496 ANWIISREMGYNY--------CQSGQSSRVA--------RDHAMTEADIEQLRQLGNR--DPLSE 542

  Fly  1045 VALAKKTHHRSQSDATVLLADFRSPHTLSISHRMYQQPPYTTQTLPTTPAKLCLGDLTSGHAFDN 1109
            :...:|              ||      ...||.|      ...:|....|:.|
Zfish   543 ITEQEK--------------DF------LWRHRQY------CVNIPEILPKILL----------- 570

  Fly  1110 GCTCFETVRGQVNGLLGQRTLCSCGAPKTSPQKEF--MKALMNVGKNLTSWPS-KAEKTSALRMS 1171
                                     |.|.:.:.|.  |..|      |..||: |.|:      :
Zfish   571 -------------------------AVKWNSRDEVAQMYCL------LKDWPAIKPEQ------A 598

  Fly  1172 LNLINKNLPARVWLPLYSDIPHHVVRITEEKTAVLNSKDKTPYII-YVEVVEIPDIYTSPLI--- 1232
            :.|::.|.|.    |:..|.   .||..|:   .|.....:.|:| .|:|::......:||:
Zfish   599 MELLDCNYPD----PMIRDF---AVRCLEK---YLTDDKLSQYLIQLVQVLKYEQYLDNPLVRFL 653

  Fly  1233 -PKMMPSLR-------HTKSEEHLD------GSCLNSHQHLSCSRTSSCSSSQQGTSCRRKKGAD 1283
             .|.:.:.|       |.|||.|..      |..|.|:                   ||
Zfish   654 LKKALTNQRIGHFFFWHLKSEMHNKTVSQRFGLLLESY-------------------CR------ 693

  Fly  1284 VDGGCGDAGPHNSCSNVHSLGGLQFQEDDVWSQEEDEITAQYLNMRKVSERDTISQIS----LDS 1344
               .||....|.| ..|.::..| ....|:..||:.:.|      :||..:..:.|:.    :|:
Zfish   694 ---ACGMYLKHLS-RQVEAMEKL-INLTDILKQEKKDET------QKVQMKFLVEQMRRPDYMDA 747

  Fly  1345 CDSRDQGPPVVFNIGDVRLRHCSNLSCENTKSFSNDPEDPSAAALKEPWHEKE---KLIRESSPY 1406
            ..:..........:|::||..|..:|......:.|             |...:   :|:.:::
Zfish   748 LQNFTSPLNPAHQLGNLRLEDCRIMSSAKRPLWLN-------------WENPDIMSELLFQNN-- 797

  Fly  1407 GHLSNWRLLSAIVKCGDDLRQELMATQLLQMFKIIWQEEQVDLWVRPYKIVCLSNDSGLIEPI-- 1469
                     ..|.|.||||||:::..|::::.:.|||.:.:||.:.||..:.:.:..||||.:
Zfish   798 ---------EIIFKNGDDLRQDMLTLQIIRIMENIWQNQGLDLRMLPYGCLSIGDCVGLIEVVRS 853

  Fly  1470 ------------------LNTVSLHQIKKNSNKSLKEYFIDEYGSPSGESFRRAQKNFVQSCAAY 1516
                              .|:.:|||..|:.||              ||.:..|...|.:|||.|
Zfish   854 SHTIMQIQCKGGLKGALQFNSTTLHQWLKDKNK--------------GEMYDMAIDLFTRSCAGY 904

  Fly  1517 CLISYLLQVKDRHNGNILFHSDGHIIHIDFGFILSISPKNLGF--EQSPFKLTPEFVEVM--GG- 1576
            |:.:::|.:.||||.||:...||.:.|||||..|....|..|:  |:.||.||.:|:.|:  ||
Zfish   905 CVATFILGIGDRHNSNIMVKDDGQLFHIDFGHFLDHKKKKFGYKRERVPFVLTQDFLIVISKGGT 969

  Fly  1577 ---TSSEHWREFNKLLLVGMMSARKHMDRIINFVEIMRSNA--HLPCFKNGCSGTVQNLRKRFHM 1636
               |.:..:..|.::.....::.|:|.:..||...:|..:.  .|..|.:     :..:||...:
Zfish   970 QECTKTREFERFQEMCYKAYLAIRQHANLFINLFSMMLGSGMPELQSFDD-----IAYIRKTLAL 1029

  Fly  1637 NLTEQE 1642
            :.||||
Zfish  1030 DKTEQE 1035

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	79/291 (27%)
pik3ca	XP_009304451.1	PI3K_p85B	31..108	CDD:197539
		PI3K_rbd	173..292	CDD:307097
		C2_PI3K_class_I_alpha	325..484	CDD:176043	26/148 (18%)
		PI3Ka_I	529..696	CDD:238444	49/280 (18%)
		PKc_like	695..1065	CDD:328722	99/392 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.810