Protein Alignment fwd and PRKDC

DIOPT Version :9

• Sequence 1: NP_001356971.1
• Gene: fwd / 45374
• FlyBaseID: FBgn0004373
• Length: 1682
• Species: Drosophila melanogaster
• Sequence 2: NP_008835.5
• Gene: PRKDC / 5591
• HGNCID: 9413
• Length: 4128
• Species: Homo sapiens
• Alignment Length: 1616
• Identity: 322/1616 - (19%)
• Similarity: 537/1616 - (33%)
• Gaps: 516/1616 - (31%)

  Fly   330 LSLDFRSMGIL--LPPVSQVTNNHINHTQHHRNRSLDSALQRIPEVEVSSPNAESENTFCSPSIL 392
            |:.|....|::  .|.:..:..|..:|.....:.:||..|              :.|:..||.|
Human  2501 LAKDVLIQGLIDENPGLQLIIRNFWSHETRLPSNTLDRLL--------------ALNSLYSPKI- 2550

  Fly   393 GATMCSKIATTAATVTSALSPPGTPTPALMSTACTPTIGAVKGNVQHPVPKHE-QSISLAAACRS 456
             ......:||......:::| |..|.|..                :||:.:.| |..::.:..|.
Human  2551 -EVHFLSLATNFLLEMTSMS-PDYPNPMF----------------EHPLSECEFQEYTIDSDWRF 2597

  Fly   457 SAVVESCPTLRMRPKSSESVAANGQEMIGVIVSSTGNGSSSSNNSCSSAG---STKKREDL---- 514
            .:.|       :.|...|:.|:.     |.:.:.|..||.|:.  ...||   :|:::.|.
Human  2598 RSTV-------LTPMFVETQASQ-----GTLQTRTQEGSLSAR--WPVAGQIRATQQQHDFTLTQ 2648

  Fly   515 TSLGSDDSGIICGSESDQISLNRICHSHESLDSGEMDADADAEEECVDLMDTTSI---------- 569
            |:.|......:.||.:|.:    :.|:..|.||...   |....|.:......|:
Human  2649 TADGRSSFDWLTGSSTDPL----VDHTSPSSDSLLF---AHKRSERLQRAPLKSVGPDFGKKRLG 2706

  Fly   570 ---DEEYNIMQPDHLCLYPPQAASTELDCRTLRPSRKQKRQQQQ---VLERKNLPSQ---NQIES 625
               ||..|.::        ..|..|:|    ||..|:..|.|::   :..||.:..|   .:|:|
Human  2707 LPGDEVDNKVK--------GAAGRTDL----LRLRRRFMRDQEKLSLMYARKGVAEQKREKEIKS 2759

  Fly   626 EDSV--DAGVDARTRYRVMNMSQAAINVELGTASNEIDPDVNYRESHQDPIADAPSLSTPSVAST 688
            |..:  ||.|.....||..::                 ||:..:.|         ||.|| :.:.
Human  2760 ELKMKQDAQVVLYRSYRHGDL-----------------PDIQIKHS---------SLITP-LQAV 2797

  Fly   689 ASATPSVTPTPIAT----------PTPTESTKND--QVLFKNF--FGATKNAIFRTAQSIIENHE 739
            |...|.:.....::          ...|.|.||:  |.|.::|  |..|..:.|....|.|::..
Human  2798 AQRDPIIAKQLFSSLFSGILKEMDKFKTLSEKNNITQKLLQDFNRFLNTTFSFFPPFVSCIQDIS 2862

  Fly   740 KKNAAKQKEQPD--HSGTVSLVGSPNG------------GSSVPQDLVKS----PTDISKKKEFF 786
            .::||.....|.  .:|.::.:..|.|            .:.:|...|:.    |.|:.:..|..
Human  2863 CQHAALLSLDPAAVSAGCLASLQQPVGIRLLEEALLRLLPAELPAKRVRGKARLPPDVLRWVELA 2927

  Fly   787 SLLTSSSSIKAAAAAAANSAASTPPATPTEALAANSNSKLQPLSDPSADLKVKERTLNLRLPGDS 851
            .|..|..... .......|...|...|.:..||       :..||.|...|..:..||.:...|.
Human  2928 KLYRSIGEYD-VLRGIFTSEIGTKQITQSALLA-------EARSDYSEAAKQYDEALNKQDWVDG 2984

  Fly   852 EGSEG--------------------ALTKCSS----------INSIHKLKLPVPGVVKYFISEKA 886
            |.:|.                    :|..||:          :|.|..........:.|.|..|.
Human  2985 EPTEAEKDFWELASLDCYNHLAEWKSLEYCSTASIDSENPPDLNKIWSEPFYQETYLPYMIRSKL 3049

  Fly   887 PVSDVLQKPEKGQSGLLRFFESPVF-NIHFAVHYLFYSKEPGVL-----------SFIGNKIFSF 939
               .:|.:.|..|| ||.|.:..:. .:..|:..|.||:|..:|           .:|.|.|.||
Human  3050 ---KLLLQGEADQS-LLTFIDKAMHGELQKAILELHYSQELSLLYLLQDDVDRAKYYIQNGIQSF 3110

  Fly   940 PD--QEVDLYIPQLVVMYIQ----MDELAE----------------------------------- 963
            ..  ..:|:.:.|..:..:|    :.|:.|
Human  3111 MQNYSSIDVLLHQSRLTKLQSVQALTEIQEFISFISKQGNLSSQVPLKRLLNTWTNRYPDAKMDP 3175

  Fly   964 --VLDPYLTIRCRKSVDFSLKCLWLLEAYNYQVDSLGNSHN-----------SS--RKSKLAL-M 1012
              :.|..:|.||........|...|.|..:..||..|:..:           ||  |..|.:: |
Human  3176 MNIWDDIITNRCFFLSKIEEKLTPLPEDNSMNVDQDGDPSDRMEVQEQEEDISSLIRSCKFSMKM 3240

  Fly  1013 KEIFSKREHKQTQNDLKSAGTGGLHVGEPRS--------VVALAKKTHHRSQSDA---------- 1059
            |.|.|.|  ||....|.......|| .|.::        |.:..:.:|.||:|..
Human  3241 KMIDSAR--KQNNFSLAMKLLKELH-KESKTRDDWLVSWVQSYCRLSHCRSRSQGCSEQVLTVLK 3302

  Fly  1060 TVLLAD--------------FRSPH-TLSISHRMYQQPPYTTQTLPTTPAKLCLGDLTSGHA--- 1106
            ||.|.|              ||..: .|..::|:      ....|.:.||  ||.::....|
Human  3303 TVSLLDENNVSSYLSKNILAFRDQNILLGTTYRI------IANALSSEPA--CLAEIEEDKARRI 3359

  Fly  1107 FDNGCTCFETVRGQVNGLL-----------------GQRTLCSCGAPKTSP-------------- 1140
            .:...:..|.....:.||.                 .|....||| |....
Human  3360 LELSGSSSEDSEKVIAGLYQRAFQHLSEAVQAAEEEAQPPSWSCG-PAAGVIDAYMTLADFCDQQ 3423

  Fly  1141 -QKEFMKALMNVGKNLTSWPS-KAEK-TSALRM----------------------SLNLINKNLP 1180
             :||...|.:.....|.::|: ..|| ..||::                      :|:|:.|.:.
Human  3424 LRKEEENASVIDSAELQAYPALVVEKMLKALKLNSNEARLKFPRLLQIIERYPEETLSLMTKEIS 3488

  Fly  1181 ARVWLPLYSDIPHHVVRITEEK-TAVLNSKDKT----------PYIIYVEVVEIPDIYTSPLIPK 1234
            :.......|.|.|.|..:.::: .||.:|.::.          |:||..|.....|..|.....:
Human  3489 SVPCWQFISWISHMVALLDKDQAVAVQHSVEEITDNYPQAIVYPFIISSESYSFKDTSTGHKNKE 3553

  Fly  1235 MMPSLRHTKSEEHLDGSCLNSHQHLSCSRT-----SSCSSSQQGTSCRRKKGAD-----VDGGCG 1289
            .:..::....:..:....:|:...||....     |:...::...:...||..:     :....|
Human  3554 FVARIKSKLDQGGVIQDFINALDQLSNPELLFKDWSNDVRAELAKTPVNKKNIEKMYERMYAALG 3618

  Fly  1290 DAGPHNSCSNVHSLGGLQFQEDDVWSQEEDEI----TAQYLNMRKVSERDTISQISLDSCDSRDQ 1350
            |       .....||..:.:....:.:|.|:.    .::.|.| |:|:.:.|:.:.|... ::|.
Human  3619 D-------PKAPGLGAFRRKFIQTFGKEFDKHFGKGGSKLLRM-KLSDFNDITNMLLLKM-NKDS 3674

  Fly  1351 GPPVVFNIGDVRLRHCSN-LSCENTKSFSNDPEDPS-------------------------AAAL 1389
            .||     |:  |:.||. :|....:...|:.|.|.                         .|:|
Human  3675 KPP-----GN--LKECSPWMSDFKVEFLRNELEIPGQYDGRGKPLPEYHVRIAGFDERVTVMASL 3732

  Fly  1390 KEPWHEKEKLIRESSPYGHLSNWRLLSAIVKCGDDLRQELMATQLLQMFKIIWQEE----QVDLW 1450
            :.|   |..:||     ||  :.|....:||.|:||||:....||.|:...|..::    |..|.
Human  3733 RRP---KRIIIR-----GH--DEREHPFLVKGGEDLRQDQRVEQLFQVMNGILAQDSACSQRALQ 3787

  Fly  1451 VRPYKIVCLSNDSGLIEPILNTVSL-------------------------------------HQI 1478
            :|.|.:|.:::..||||.:.|||:|                                     |.:
Human  3788 LRTYSVVPMTSRLGLIEWLENTVTLKDLLLNTMSQEEKAAYLSDPRAPPCEYKDWLTKMSGKHDV 3852

  Fly  1479 ------KKNSNKS-----------------LKEYFIDEYGSPSGESFRRAQKNFVQSCAAYCLIS 1520
                  .|.:|::                 ||..|:....||  |:|...:.:|..|.|..|:..
Human  3853 GAYMLMYKGANRTETVTSFRKRESKVPADLLKRAFVRMSTSP--EAFLALRSHFASSHALICISH 3915

  Fly  1521 YLLQVKDRHNGNILFHSD-GHIIHIDFGFILSISPKNLGF-EQSPFKLTPEFVEVM 1574
            ::|.:.|||..|.:...: |.:|.||||.....:.:.|.. |..||:||.:|:.:|
Human  3916 WILGIGDRHLNNFMVAMETGGVIGIDFGHAFGSATQFLPVPELMPFRLTRQFINLM 3971

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	66/281 (23%)
PRKDC	NP_008835.5	HEAT 1	288..323
		HEAT 2	1004..1040
		Interaction with C1D. /evidence=ECO:0000269|PubMed:9679063	1503..1538
		Leucine-zipper	1503..1538
		TPR 1	1723..1756
		NUC194	1816..2202	CDD:400469
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	2050..2073
		KIP-binding	2436..3212		159/815 (20%)
		FAT	3023..3470	CDD:396714	89/462 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	3200..3222		5/21 (24%)
		PIKKc_DNA-PK	3719..4015	CDD:270716	66/265 (25%)
		FATC	4097..4128	CDD:396715

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810