Protein Alignment fwd and ATR

DIOPT Version :9

• Sequence 1: NP_001356971.1
• Gene: fwd / 45374
• FlyBaseID: FBgn0004373
• Length: 1682
• Species: Drosophila melanogaster
• Sequence 2: XP_011511226.1
• Gene: ATR / 545
• HGNCID: 882
• Length: 2646
• Species: Homo sapiens
• Alignment Length: 788
• Identity: 153/788 - (19%)
• Similarity: 257/788 - (32%)
• Gaps: 293/788 - (37%)

  Fly  1118 RGQVNGLLGQRTLCSCG-APKTSPQKEFMKALMNVGKNLTS----------WPSKAEKTSALRMS 1171
            |...|.::|:..|.|.. |.|....:....||:|.|::..:          | ||.:...||.:.
Human  1915 RPDYNEMVGECWLQSARVARKAGHHQTAYNALLNAGESRLAELYVERAKWLW-SKGDVHQALIVL 1978

  Fly  1172 LNLINKNLPARVWLPLYSDIPHH------VVRITE-----EKTAVLNS-KDKTPYIIYVEVVEIP 1224
            ...:....|.....|...::..|      |.|..|     |..|::.. ||.|..        :|
Human  1979 QKGVELCFPENETPPEGKNMLIHGRAMLLVGRFMEETANFESNAIMKKYKDVTAC--------LP 2035

  Fly  1225 D-----IYTSPLIPKMMPSLRHTKSEEHLD---------GSCL---NSHQHLSCSR--------- 1263
            :     .|.:....|:||.:...|.|:..|         |..|   |...:.|..|
Human  2036 EWEDGHFYLAKYYDKLMPMVTDNKMEKQGDLIRYIVLHFGRSLQYGNQFIYQSMPRMLTLWLDYG 2100

  Fly  1264 TSSCSSSQQGTSCRRKKGADVDGGCGDAGPHNSCSNVHS--LGGLQFQEDDVWSQEEDEITAQYL 1326
            |.:....:.|.|.|.:..       .|.|..|.....|:  |...||            :||
Human  2101 TKAYEWEKAGRSDRVQMR-------NDLGKINKVITEHTNYLAPYQF------------LTA--- 2143

  Fly  1327 NMRKVSERDTISQISLDSCDSRDQGPPVVFNI-----------------------GDVRLRHCS- 1367
                      .||:....|.|.|:...|:..|                       ..:|:..|.
Human  2144 ----------FSQLISRICHSHDEVFVVLMEIIAKVFLAYPQQAMWMMTAVSKSSYPMRVNRCKE 2198

  Fly  1368 --NLSCENTKSFS-----------------NDPEDPSAAALKEPWHEK--EKLIRESS------- 1404
              |.:....||..                 |.|.|.|::.|....|.|  :||:.|::
Human  2199 ILNKAIHMKKSLEKFVGDATRLTDKLLELCNKPVDGSSSTLSMSTHFKMLKKLVEEATFSEILIP 2263

  Fly  1405 -----------------------PY-GHLSNWRLLSA---------------------------I 1418
                                   |: ||   |..::.                           |
Human  2264 LQSVMIPTLPSILGTHANHASHEPFPGH---WAYIAGFDDMVEILASLQKPKKISLKGSDGKFYI 2325

  Fly  1419 VKC--GDDLRQELMATQLLQMFKII-------WQEEQVDLWVRPYKIVCLSNDSGLIEPILNTVS 1474
            :.|  .||||::   .:|::...:|       .:..:.:|.:|.|.::.|:::.|:||.:.||..
Human  2326 MMCKPKDDLRKD---CRLMEFNSLINKCLRKDAESRRRELHIRTYAVIPLNDECGIIEWVNNTAG 2387

  Fly  1475 LHQIKKN---------SNKSLK------------------------------EYFIDEYGSPSGE 1500
            |..|...         :.|.|:                              |:|:..:..|:
Human  2388 LRPILTKLYKEKGVYMTGKELRQCMLPKSAALSEKLKVFREFLLPRHPPIFHEWFLRTFPDPT-- 2450

  Fly  1501 SFRRAQKNFVQSCAAYCLISYLLQVKDRHNGNILFHS-DGHIIHIDFGFILSISPKNLGFEQS-- 1562
            |:..::..:.:|.|...::.|:|.:.|||..||||.| .|..:|:||..:.:   |...||..
Human  2451 SWYSSRSAYCRSTAVMSMVGYILGLGDRHGENILFDSLTGECVHVDFNCLFN---KGETFEVPEI 2512

  Fly  1563 -PFKLTPEFVEVMGGTSSEHWREFNKLLLVGM----------MSARKHM--DRIINFVEIMRSNA 1614
             ||:||...|..||...:|..  |.:...|.|          ||..|..  |.::.:.:.::.::
Human  2513 VPFRLTHNMVNGMGPMGTEGL--FRRACEVTMRLMRDQREPLMSVLKTFLHDPLVEWSKPVKGHS 2575

  Fly  1615 HLPCFKNGCSGTVQNLRKRFHMNLTEQEM-----------------ERKVEQLVQDSL-KSLSTK 1661
            ..|..:   :|.|.|.:.:.|:...||.:                 |..|..|:|::. ::|..:
Human  2576 KAPLNE---TGEVVNEKAKTHVLDIEQRLQGVIKTRNRVTGLPLSIEGHVHYLIQEATDENLLCQ 2637

  Fly  1662 LYDGYQYY 1669
            :|.|:..|
Human  2638 MYLGWTPY 2645

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	85/427 (20%)
ATR	XP_011511226.1	UME	1119..1224	CDD:214825
		FAT	1773..2094	CDD:280429	40/187 (21%)
		TEL1	<2135..2646	CDD:227365	105/552 (19%)
		PIKKc_ATR	2295..2569	CDD:270625	59/283 (21%)
		FATC	2615..2646	CDD:280430	8/31 (26%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900