DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fwd and PIK3CD

DIOPT Version :9

Sequence 1:	NP_001356971.1	Gene:	fwd / 45374	FlyBaseID:	FBgn0004373	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	XP_016856965.1	Gene:	PIK3CD / 5293	HGNCID:	8977	Length:	1103	Species:	Homo sapiens

Alignment Length:	671	Identity:	148/671 - (22%)
Similarity:	249/671 - (37%)	Gaps:	189/671 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly  1155 LTSWPSKAEKTSALRMSLNLI----NKNLPARVWLPLYSDIPHHVVRITEEKT---AVLNSKDKT 1212
            |..|||..::...|......:    |.:..|.:.:.|....||.|.....||.   .:|.|::..
Human   439 LYMWPSVPDEKGELLNPTGTVRSNPNTDSAAALLICLPEVAPHPVYYPALEKLPGGMLLASREWR 503

  Fly  1213 PYIIYVEVVEIPDIYTSPLIPKMMPSLRHTKS--EEHLDGSCLNSHQHLSCSRTSSCSSSQQGTS 1275
            |.::::. :...|...|.:|...||.|.....  :...|..|....|.|...|.|.|....:...
Human   504 PELLWMR-LHAEDSAPSRMIGVAMPGLGVLPGLVQAPGDAECSRLLQILELGRHSECVHVTEEEQ 567

  Fly  1276 CRRKKGADVDGGCGDAGPHNSCSNVHSLGGLQFQEDDVWSQEED------EITAQYLNMRKVSER 1334
            .:.::..: ..|.|:...|              ::|.||....:      |..|:.|.:.|.::.
Human   568 LQLREILE-RRGSGELYEH--------------EKDLVWKLRHEVQEHFPEALARLLLVTKWNKH 617

  Fly  1335 DTISQISLDSCDSRDQGPPVV-----------------FNIGDVR-----------------LRH 1365
            :.::|:....|...:.  ||:                 |.|..:|                 |::
Human   618 EDVAQMLYLLCSWPEL--PVLSALELLDFSFPDCHVGSFAIKSLRKLTDDELFQYLLQLVQVLKY 680

  Fly  1366 CSNLSCENTK------------------SFSNDPEDPSAA----ALKEPW------HEK------ 1396
            .|.|.||.||                  ...::...||.|    .:.|.:      |.|
Human   681 ESYLDCELTKFLLDRALANRKIGHFLFWHLRSEMHVPSVALRFGLILEAYCRGSTHHMKVLMKQG 745

  Fly  1397 ------------EKLIRESSP--------------------YGHLSN------------------ 1411
                        .||..:.:|                    ..||.:
Human   746 EALSKLKALNDFVKLSSQKTPKPQTKELMHLCMRQEAYLEALSHLQSPLDPSTLLAEVCVEQCTF 810

  Fly  1412 --------WRLLS-----------AIVKCGDDLRQELMATQLLQMFKIIWQEEQVDLWVRPYKIV 1457
                    |.:.|           .|.|.||||||:::..|::|:..::|::|.:||.:.||..:
Human   811 MDSKMKPLWIMYSNEEAGSGGSVGIIFKNGDDLRQDMLTLQMIQLMDVLWKQEGLDLRMTPYGCL 875

  Fly  1458 CLSNDSGLIEPILNTVSLHQIKKN-SNKSL-----KEYFIDEYGSPS-GESFRRAQKNFVQSCAA 1515
            ...:.:||||.:|.:.::..|:.| ||.:.     |:..::...|.: ||:..||.:.|..|||.
Human   876 PTGDRTGLIEVVLRSDTIANIQLNKSNMAATAAFNKDALLNWLKSKNPGEALDRAIEEFTLSCAG 940

  Fly  1516 YCLISYLLQVKDRHNGNILFHSDGHIIHIDFGFILSISPKNLGF--EQSPFKLTPEFVEVM--GG 1576
            ||:.:|:|.:.|||:.||:....|.:.|||||..|.......|.  |:.||.||.:||.|:  |.
Human   941 YCVATYVLGIGDRHSDNIMIRESGQLFHIDFGHFLGNFKTKFGINRERVPFILTYDFVHVIQQGK 1005

  Fly  1577 T-SSEHWREFNKLLLVGMMSARKHMDRIINFVEIMRSNAHLPCFKNGCSGTVQNLRKRFHMNLTE 1640
            | :||.:..|...........|:|....::...:||: |.||  :..||..:|.|:....:..||
Human  1006 TNNSEKFERFRGYCERAYTILRRHGLLFLHLFALMRA-AGLP--ELSCSKDIQYLKDSLALGKTE 1067

  Fly  1641 QEMER----KVEQLVQDSLKS 1657
            :|..:    |..:.:::|.|:
Human  1068 EEALKHFRVKFNEALRESWKT 1088

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	94/374 (25%)
PIK3CD	XP_016856965.1	PI3K_p85B	32..107	CDD:308030
		PI3K_rbd	175..281	CDD:307097
		C2_PI3K_class_I_beta_delta	314..481	CDD:176075	8/41 (20%)
		PI3Ka	562..743	CDD:214537	30/197 (15%)
		PI3Kc_IA_delta	735..1101	CDD:270718	91/357 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810