Protein Alignment fwd and PIK3C2G

DIOPT Version :9

• Sequence 1: NP_001356971.1
• Gene: fwd / 45374
• FlyBaseID: FBgn0004373
• Length: 1682
• Species: Drosophila melanogaster
• Sequence 2: XP_016874959.1
• Gene: PIK3C2G / 5288
• HGNCID: 8973
• Length: 1492
• Species: Homo sapiens
• Alignment Length: 1324
• Identity: 270/1324 - (20%)
• Similarity: 465/1324 - (35%)
• Gaps: 383/1324 - (28%)

  Fly   600 PSRKQKRQQQQVLERKNLPSQNQIESEDSVDAGVDARTRYRVMNMSQAAINVELGTASNEIDPDV 664
            |:..:..::|  .|.:.....||..|...|..|.|     ::::    .|:.::....:|||.:.
Human     9 PNPNESHEKQ--YEHQEFLFVNQPHSSSQVSLGFD-----QIVD----EISGKIPHYESEIDENT 62

  Fly   665 --------------NYRESHQDPIADAPSLSTPSVASTASATPSVTPTPIATPTPTESTK----- 710
                          :..|:||..:.:..|.|........|..|::..:|...|.|..:.|
Human    63 FFVPTAPKWDSTGHSLNEAHQISLNEFTSKSRELSWHQVSKAPAIGFSPSVLPKPQNTNKECSWG 127

  Fly   711 ---------ND---QVLFKNFFGATKNAIFRTAQSIIENHE----------KKNAA-----KQKE 748
                     :|   .:|..:|....|..:.:..::  |||.          ..|::     ..||
Human   128 SPIGKHHGADDSRFSILAPSFTSLDKINLEKELEN--ENHNYHIGFESSIPPTNSSFSSDFMPKE 190

  Fly   749 QPDHSGTVSLV--------GS--PNGGSSVPQ----------DLVKSPTDISKKKEFFSLLTSSS 793
            :...||.|::|        ||  |....|..|          .||:.|...:.     ||.:..:
Human   191 ENKRSGHVNIVEPSLMLLKGSLQPGMWESTWQKNIESIGCSIQLVEVPQSSNT-----SLASFCN 250

  Fly   794 SIKA------AAAAAANSAA--STPPATPTEALAANS-------NSKLQPLS-DPSADLKVKER- 841
            .:|.      ||....||..  ||..|.|.:..:...       ::..|||. .|.|:..||:.
Human   251 KVKKIRERYHAADVNFNSGKIWSTTTAFPYQLFSKTKFNIHIFIDNSTQPLHFMPCANYLVKDLI 315

  Fly   842 -------TLNLRLPGDSEGSEGALTKCSS---INSIHKLKLPVPGVVKYFISEKAPVSDVLQKPE 896
                   |.:..||.|.     .|:.|.|   :.:.|.|     |..|.|..:|:.:...|||..
Human   316 AEILHFCTNDQLLPKDH-----ILSVCGSEEFLQNDHCL-----GSHKMFQKDKSVIQLHLQKSR 370

  Fly   897 KGQSGLLRFFESPVFNIHFAVHYLFYSKEPGVLSFIGNKIFSFPDQEVDLYIPQLVVMYIQMDEL 961
            :....|.|..|..        |..||.          |::..|           :.:..:....|
Human   371 EAPGKLSRKHEED--------HSQFYL----------NQLLEF-----------MHIWKVSRQCL 406

  Fly   962 AEVLDPYLTIRCRKSVDFSLKCLWLLEAYNYQVDSLGNSHNSSRK-SKLALMKEIFSKREHKQTQ 1025
            ..::..|         ||.||         |.:.:..|.:|...: .|:..:......::.....
Human   407 LTLIRKY---------DFHLK---------YLLKTQENVYNIIEEVKKICSVLGCVETKQITDAV 453

  Fly  1026 NDLKSAGTGGLHVGEPRSVVALAK--KTHHRSQSDATVLLADFRSPHTLSISHRMYQ-------- 1080
            |:|              |::...|  ..:..|::.|..|:...    |..:|..:||
Human   454 NEL--------------SLILQRKGENFYQSSETSAKGLIEKV----TTELSTSIYQLINVYCNS 500

  Fly  1081 -----QP---PYTTQTL-PTTPAKLCLGDLTSGH-----------AFDNGCTCFETVRGQVNGLL 1125
                 ||   |..|..| |..|:.|.. .:.:.|           ||  ..||:.|..|
Human   501 FYADFQPVNVPRCTSYLNPGLPSHLSF-TVYAAHNIPETWVHSYKAF--SFTCWLTYAG------ 556

  Fly  1126 GQRTLCSCGAPKTSPQKEFMKALMNVGK-------------------------------NLTSW- 1158
              :.||.....:..|.|:....|:|..:                               ||.:|
Human   557 --KKLCQVRNYRNIPDKKLFFFLVNWNETINFPLEIKSLPRESMLTVKLFGIACATNNANLLAWT 619

  Fly  1159 -----PSKAEKTSALRMSLNL-----------------------INKNLPARVWLPLYSDIPH-- 1193
                 |.:.....::..|:.|                       :..:.||..|..:..|...
Human   620 CLPLFPKEKSILGSMLFSMTLQSEPPVEMITPGVWDVSQPSPVTLQIDFPATGWEYMKPDSEENR 684

  Fly  1194 ------------HVVRITEEKTAVLNSKDKTPYIIYVEVVEIPDIYTSPLIPKMMPSL-RHTKSE 1245
                        |:.|:::::|.:|.|::|..|:.:.......:..:.||:....|.. ..|.||
Human   685 SNLEEPLKECIKHIARLSQKQTPLLLSEEKKRYLWFYRFYCNNENCSLPLVLGSAPGWDERTVSE 749

  Fly  1246 EHLDGSCLNSHQHLSCSRTSSCSSSQQGTSCRRKKGADVDGGCGD-------------------A 1291
            .|.........|.|..  ....:||......|:.....:|....|                   .
Human   750 MHTILRRWTFSQPLEA--LGLLTSSFPDQEIRKVAVQQLDNLLNDELLEYLPQLVQAVKFEWNLE 812

  Fly  1292 GPHNSCSNVHSLGGLQFQEDDVWSQEEDEITAQYLN--MRKVSERDTISQISLDSCDSRDQGPPV 1354
            .|........||..:|......|..:..|..|.:.:  .:.::.....:..:|:...|::|  .:
Human   813 SPLVQLLLHRSLQSIQVAHRLYWLLKNAENEAYFKSWYQKLLAALQFCAGKALNDEFSKEQ--KL 875

  Fly  1355 VFNIGDV--RLRHCSNLSCENT--------KSFSND------PEDPSAAALKEPWHE-------- 1395
            :..:||:  |::..|:...:..        :.|..|      |.:| |..:|...|:
Human   876 IKILGDIGERVKSASDHQRQEVLKKEIGRLEEFFQDVNTCHLPLNP-ALCIKGIDHDACSYFTSN 939

  Fly  1396 ----KEKLIRESSPYGHLSNWRLLSAIVKCGDDLRQELMATQLLQMFKIIWQEEQVDLWVRPYKI 1456
                |...| .::|.|     :.:|.|.|.||||||:::..||:|:...||.:|.:|:.:..|:.
Human   940 ALPLKITFI-NANPMG-----KNISIIFKAGDDLRQDMLVLQLIQVMDNIWLQEGLDMQMIIYRC 998

  Fly  1457 VCLSNDSGLIEPILNTVSLHQIKKNSN--KSLKEYFIDEYGSPSGE---SFRRAQKNFVQSCAAY 1516
            :....|.||::.:.:.|:|.:|.::|.  ..|||..|.::.|....   .:.:|.:||..|||.:
Human   999 LSTGKDQGLVQMVPDAVTLAKIHRHSGLIGPLKENTIKKWFSQHNHLKADYEKALRNFFYSCAGW 1063

  Fly  1517 CLISYLLQVKDRHNGNILFHSDGHIIHIDFGFILSISPKNLGF--EQSPFKLTP--EFVEVMGGT 1577
            |:::::|.|.||||.||:....||:.|||||..|..:....|.  :::||..|.  |:....||.
Human  1064 CVVTFILGVCDRHNDNIMLTKSGHMFHIDFGKFLGHAQTFGGIKRDRAPFIFTSEMEYFITEGGK 1128

  Fly  1578 SSEHWREFNKLLLVGMMSARKHMDRIINFVEIMRSNAHLPCFKNGCSGTVQNLRKRFHMNL---- 1638
            :.:|:::|.:|........|||...::|.:|:| ..|.||    ..|| :|:| |..:.||
Human  1129 NPQHFQDFVELCCRAYNIIRKHSQLLLNLLEMM-LYAGLP----ELSG-IQDL-KYVYNNLRPQD 1186

  Fly  1639 TEQEMERKVEQLVQDSLKSLSTKL 1662
            |:.|......:.:::||:....||
Human  1187 TDLEATSHFTKKIKESLECFPVKL 1210

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	91/303 (30%)
PIK3C2G	XP_016874959.1	None

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810