DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fwd and PIK3C2B

DIOPT Version :9

Sequence 1:	NP_001356971.1	Gene:	fwd / 45374	FlyBaseID:	FBgn0004373	Length:	1682	Species:	Drosophila melanogaster
Sequence 2:	NP_001364263.1	Gene:	PIK3C2B / 5287	HGNCID:	8972	Length:	1634	Species:	Homo sapiens

Alignment Length:	1623	Identity:	310/1623 - (19%)
Similarity:	518/1623 - (31%)	Gaps:	555/1623 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   259 GQMPTIKCLPGASSAAST------------PKHSRYSK--------PRLSLSRVFNHSMPSVHGR 303
            |:...:|.|.|.|.:..|            |.||....        |:.|||..:.:......|.
Human    73 GRRTDLKLLRGLSGSDPTLNYNSLSPQEGPPNHSTSQGPQPGSDPWPKGSLSGDYLYIFDGSDGG 137

  Fly   304 PNLSLAPAGVPGSVN-------------------PPKRISTHQRNLS--LDFRSMGILLPPVSQV 347
            .:.|..|..:.||..                   ||::.|.....:|  .|..:..:    |.|:
Human   138 VSSSPGPGDIEGSCKKLSPPPLPPRASIWDTPPLPPRKGSPSSSKISQPSDINTFSL----VEQL 198

  Fly   348 TNNHINHTQHHRNRSLDSALQ--RIPEVEVSSPN-----AESENTFCSPSILGATM--------- 396
            ....:.|........|....|  .:..|:....|     ...::|:.:..:..||.
Human   199 PGKLLEHRILEEEEVLGGGGQGRLLGSVDYDGINDAITRLNLKSTYDAEMLRDATRGWKEGRGPL 263

  Fly   397 -CSKIATTAATVTSALSPPGTPTPALMSTACTPTIGAVKGNVQHPVPKHEQSISLA-AACRSSAV 459
             .||..:......|...||..|         ..|..:..||.::..|...:.||.| ...|...|
Human   264 DFSKDTSGKPVARSKTMPPQVP---------PRTYASRYGNRKNATPGKNRRISAAPVGSRPHTV 319

  Fly   460 VESCPTLRMRPKSSESVAANGQEMIGVIVSS--------TGNGSSSSNNSCSSAGS--------- 507
            ........:..:..|.||| ...|:.::.|.        ||...|:...|....|.
Human   320 ANGHELFEVSEERDEEVAA-FCHMLDILRSGSDIQDYFLTGYVWSAVTPSPEHLGDEVNLKVTVL 383

  Fly   508 -TKKREDLTSLGSDDSGIICGSESDQISLNRICHSHESLDSGEMDADADAEEECVDLMDTTSIDE 571
             .:.:|.||...:      |.|..|.:....:|::|:.|.:             ||:.|.
Human   384 CDRLQEALTFTCN------CSSTVDLLIYQTLCYTHDDLRN-------------VDVGDF----- 424

  Fly   572 EYNIMQPDHLCLYPPQAASTELDCRTLRPSRKQKRQQQQVLERKN-LPSQNQIESEDSVDAGVDA 635
               :::|..|                           ::.|:.|: |.|...|:.....|..:
Human   425 ---VLKPCGL---------------------------EEFLQNKHALGSHEYIQYCRKFDIDI-- 457

  Fly   636 RTRYRVMNMSQAAINVELGTASNEIDPDVNYRESHQDPIADAPSLSTPSVASTASATPSVTPTPI 700
                |:..|.|..:..:|....|:          .|.|             ||.:....:...|:
Human   458 ----RLQLMEQKVVRSDLARTVND----------DQSP-------------STLNYLVHLQERPV 495

  Fly   701 ATPTPTESTKNDQVLFKNFFGATKNAIFRTAQSIIEN--HEKKNAAKQKEQPDHSGTVSLVGSPN 763
                                   |..|.|.|.|::.:  |.:.:|....:
Human   496 -----------------------KQTISRQALSLLFDTYHNEVDAFLLAD--------------- 522

  Fly   764 GGSSVPQDLVKSPTDISKKKEFFSLLTSSSSIKAAAAAAANSAASTPPATPTEALAANSNSKLQP 828
            |...:..|.|                  ..|:||...|.|  |..||..|..........|::||
Human   523 GDFPLKADRV------------------VQSVKAICNALA--AVETPEITSALNQLPPCPSRMQP 567

  Fly   829 --LSDPSADLKVKERTLNLRLPGDSEGSEGALTK---------CSSINSIHKLKLPVPGVVKYFI 882
              ..|||. |.|:|         :.|....|||.         |::.|:  ..:..|||..|:.:
Human   568 KIQKDPSV-LAVRE---------NREKVVEALTAAILDLVELYCNTFNA--DFQTAVPGSRKHDL 620

  Fly   883 SEKAPVSDVLQKPEKGQSGLLRFFESPVFNIHFAVH-------------YLFYSKEPGVLSFIGN 934
            .::|                ..|..|..|.: :|.|             ||..|     ||..|.
Human   621 VQEA----------------CHFARSLAFTV-YATHRIPIIWATSYEDFYLSCS-----LSHGGK 663

  Fly   935 KIFSFPDQEVDLYIPQLVVMYIQMDELAEVLDPYLTIRCRKSVDFSLKCLWLLEAYNYQVDSLGN 999
            ::.| |.|....:..:.:...|..|:  ::..|....|..:.   :|.|..|   |...:...|:
Human   664 ELCS-PLQTRRAHFSKYLFHLIVWDQ--QICFPVQVNRLPRE---TLLCATL---YALPIPPPGS 719

  Fly  1000 SHNSSRKSKLA-----LMKEIFSKREHKQTQNDLKSAGTGGLHVGEPRSVVALAKKTHHR----- 1054
            |..::::.::.     :...:|:.|:       :.:.|         |.::.|...|...
Human   720 SSEANKQRRVPEALGWVTTPLFNFRQ-------VLTCG---------RKLLGLWPATQENPSARW 768

  Fly  1055 -----SQSDATVLLADFRSPHTLSISHRMYQQPPYTTQTLPTTPAKLCLGDLTSGHAFDNGCTCF 1114
                 .|.|:.:|..||                       ||:             |||...|
Human   769 SAPNFHQPDSVILQIDF-----------------------PTS-------------AFDIKFT-- 795

  Fly  1115 ETVRGQVNGLLGQRTLCSCGAPKTSPQKEF----------MKALMNVGKNLTSWPSKAEKTSALR 1169
                             |....|.||:.||          :|.:|.  |....|.:.|:|.....
Human   796 -----------------SPPGDKFSPRYEFGSLREEDQRKLKDIMQ--KESLYWLTDADKKRLWE 841

  Fly  1170 ---------MSLNLINKNLPARVW--LP--------------------LYSDIPHHVVRITEEKT 1203
                     .||.|:..:.|:..|  ||                    |::..|...||    :.
Human   842 KRYYCHSEVSSLPLVLASAPSWEWACLPDIYVLLKQWTHMNHQDALGLLHATFPDQEVR----RM 902

  Fly  1204 AV-----LNSKDKTPYI-IYVEVVEIPDIYTSPLI----PKMMPSLRHTK------SEEHLDGSC 1252
            ||     |:..:...|: ..|:.::......|||:    .:.:..||.|.      .:...|...
Human   903 AVQWIGSLSDAELLDYLPQLVQALKYECYLDSPLVRFLLKRAVSDLRVTHYFFWLLKDGLKDSQF 967

  Fly  1253 LNSHQHLSCSRTSSCSSSQQGTSCRRKKGADVDGGCGDAGPHNSCSNVHSLGGLQFQEDDVWSQE 1317
            ...:|:|..:....|     |...|.:.             :..|..|::|..|
Human   968 SIRYQYLLAALLCCC-----GKGLREEF-------------NRQCWLVNALAKL----------- 1003

  Fly  1318 EDEITAQYLNMRKVSERDTISQISLDSCDSRDQGPPVVFNIGDVRLRHCSNLSCENTKSFS---- 1378
                 ||.:.....|.|..|.:..|:                :|:.....|.||....|.|
Human  1004 -----AQQVREAAPSARQGILRTGLE----------------EVKQFFALNGSCRLPLSPSLLVK 1047

  Fly  1379 -NDPEDPS-----AAALKEPWHEKEKLIRESSPYGHLSNWRLLSAIVKCGDDLRQELMATQLLQM 1437
             ..|.|.|     |..||..:...:       |.|  .|.|:   |.||||||||:::..|::::
Human  1048 GIVPRDCSYFNSNAVPLKLSFQNVD-------PLG--ENIRV---IFKCGDDLRQDMLTLQMIRI 1100

  Fly  1438 FKIIWQEEQVDLWVRPYKIVCLSNDSGLIEPILNTVSLH--QIKKNSNKSLKEYFIDEY---GSP 1497
            ...||.:|.:|:.:..::........|::|.|.|..:|.  |::.....|.|:..:.::   .:|
Human  1101 MSKIWVQEGLDMRMVIFRCFSTGRGRGMVEMIPNAETLRKIQVEHGVTGSFKDRPLADWLQKHNP 1165

  Fly  1498 SGESFRRAQKNFVQSCAAYCLISYLLQVKDRHNGNILFHSDGHIIHIDFGFILSISPK--NLGFE 1560
            ..:.:.:|.:||:.|||..|:.:|:|.:.||||.||:..:.||:.|||||..|..:..  |:..:
Human  1166 GEDEYEKAVENFIYSCAGCCVATYVLGICDRHNDNIMLKTTGHMFHIDFGRFLGHAQMFGNIKRD 1230

  Fly  1561 QSPFKLTPEFVEVMGG--TSSEHWREFNKLLLVGMMSARKHMDRIINFVEIMRSNAHLPCFKNGC 1623
            ::||..|.:...|:.|  ..|..:.:|..|........|||....:|.:.:|.|          |
Human  1231 RAPFVFTSDMAYVINGGDKPSSRFHDFVDLCCQAYNLIRKHTHLFLNLLGLMLS----------C 1285

  Fly  1624 S----GTVQNLRKRFHMNLTEQEMERKV----EQLVQDSLKSLSTKLYDGYQYYTNGILXERF 1678
            .    ..:::| |..:..|..|:.|...    .:|::.||.|::|||    .::.:.:...:|
Human  1286 GIPELSDLEDL-KYVYDALRPQDTEANATTYFTRLIESSLGSVATKL----NFFIHNLAQMKF 1343

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	82/310 (26%)
PIK3C2B	NP_001364263.1	Interaction with GRB2. /evidence=ECO:0000269\|PubMed:11533253	2..298		42/237 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	45..188		22/114 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	259..315		13/64 (20%)
		PI3K_rbd	364..466	CDD:395642	25/161 (16%)
		C2A_PI3K_class_II	622..794	CDD:175979	41/254 (16%)
		PI3Ka_II	813..981	CDD:238441	31/173 (18%)
		PI3Kc_C2_beta	987..1340	CDD:119421	101/424 (24%)
		PX_PI3K_C2_beta	1369..1477	CDD:132823
		C2B_PI3K_class_II	1505..1627	CDD:176027
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5032
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810