Protein Alignment fwd and Pi4KIIIalpha

DIOPT Version :10

• Sequence 1: NP_001356971.1
• Gene: fwd / 45374
• FlyBaseID: FBgn0004373
• Length: 1682
• Species: Drosophila melanogaster
• Sequence 2: XP_061511292.1
• Gene: Pi4KIIIalpha / 4577816
• VectorBaseID: AGAMI1_005579
• Length: 2091
• Species: Anopheles gambiae
• Alignment Length: 1191
• Identity: 258/1191 - (21%)
• Similarity: 441/1191 - (37%)
• Gaps: 356/1191 - (29%)

  Fly   669 SH-QDPIADAPSLSTPSVASTASATPSVTPTPIATPTPTESTKNDQ-------------VLFKNF 719
            || |:.....||.|..:.:..|.|..|:..|.:|..|...:||...             .|...:
Mosquito  1069 SHLQEYPNQVPSTSLSNHSGLALAVDSILHTWVANATIPTATKRPHCVNSDTSKFVSVLCLRSKY 1133

  Fly   720 FGATKNAIFRTAQSIIENHEKK-----------NAAKQKEQPDHSGTVSLVGSPNGGSSVPQDLV 773
            .|.....:     |::|:.|||           :|..:|..|.|.|.:
Mosquito  1134 AGEISGLL-----SVLEDEEKKGLADRLVRDVWDACAEKSDPKHRGAL----------------- 1176

  Fly   774 KSPTDISKKKEFFSLLTSSSSIKAAAAAAANSAASTPPATPTEALAANSNSKLQPLSDPSADLKV 838
                   .:...:.:|.||::.|                    .|.|.|:|::|..::.:.:..|
Mosquito  1177 -------WRATAYLILCSSANRK--------------------LLHAISSSQVQLFTESAMETAV 1214

  Fly   839 K--ERTLNLRLPGDSEGSEGALTKCSSINSIHKLKLPVPGVVKYFISEKAPVSDVLQKPEKGQSG 901
            :  :..|..|..         |..|                   ||.|.............|
Mosquito  1215 ECWQWILTARQD---------LELC-------------------FIQEMVTAWQTTFDKRMG--- 1248

  Fly   902 LLRFFESPVFNIHFAVHYLFYSKEPGVLS----FIGNKIFSFPDQEVDLYIPQLVVMYIQMDELA 962
                               .:|:|..|.|    :.|.::...|    .:..|.|:  ::|:  |:
Mosquito  1249 -------------------LFSEEHDVTSPLAAYEGCRLVPKP----IVVAPHLI--WLQL--LS 1286

  Fly   963 EVLDPYLTIRCRKSVDFSLKCLWLLEAYNYQVDSLGNSHNSSRKSKLALM--------------- 1012
            |::|   |.:........:.|:.|.....:..|...|.|.|:...:..|:
Mosquito  1287 EMVD---TAKYCNRDKVEMFCMLLHRCLPFSRDFKQNRHISTVGCRFKLLQCGLSLLQGNTIPKS 1348

  Fly  1013 --KEIFSKREHKQTQNDLKSAGTGGLHVGEPRSV----VALAKKTHHRSQSDATVLLADFRSP-- 1069
              :.|..:|.:   .|.|.......|...:||..    :|:..|.....:|:...|:|...|.
Mosquito  1349 LARNILRERIY---ANALDYFCGPQLCPSQPREALLEDIAILLKFWQTMRSEKKHLVASEVSDYE 1410

  Fly  1070 -HTLSISHRMYQQPPYTTQTLPTTPAKLCLGDLTSGHAFDNGCTCFETVRGQVNGLLGQRTLCSC 1133
             ||.|::..:.:....|.....:..|:    ..:||:|     ..:.|:....:      ||...
Mosquito  1411 LHTASVNLSVQKVSLDTVSLAGSEVAR----STSSGNA-----GWYNTIPHSTS------TLSKR 1460

  Fly  1134 GA-------PKTSPQKEFMK-----------------------ALMNV----GKNLTSWPSKAEK 1164
            .|       ||.:..|::||                       ||..:    .:::..|.::..|
Mosquito  1461 SARIKRPPYPKDAYDKDYMKKRNLILELLAVEIEFMLIWANPLALPELQIPGEESVAEWRARPMK 1525

  Fly  1165 TSALRMSLNLINKNLPA-RVWLP---------------LYSDIPHHVVRITEEKTAVLNSK---D 1210
            .:..|....|.....|| .|:||               |....|...|.|.|....::.:|   :
Mosquito  1526 LNVWRDFTRLAWSYNPALAVFLPQRIRNAETIEDEVTRLVCSDPMAAVHIPEALKYLVTTKTVLN 1590

  Fly  1211 KTPYIIYV---------------------------EVVEIPDIYTS----PLIPKMMPSLRH--- 1241
            :.|.::|:                           ..|:..:.|.:    |.||:::.:|||
Mosquito  1591 EAPELVYMLTWARVNPIQALSYFSRQYPTHPLTAQYAVKTLNSYPAEAVLPYIPQLVQALRHDTM 1655

  Fly  1242 ---TKSEEHLD-GSCLNSHQHLSCSRTSSCSSSQQGTSCRRKKGADVDGGCGDAGPHNSCSNVHS 1302
               |:..:|:. .|.:.:||.:...:|:.....:                            :|.
Mosquito  1656 GYVTELIKHISKRSQIVAHQLVWNMQTNMYIDEE----------------------------MHH 1692

  Fly  1303 LGGLQFQEDDVWSQEEDEITAQYLNMRKVSER--DTISQISLDSCDSRDQGPPVVFNIGDVRLRH 1365
            ...|.   |.:.|..::.|::.....::..||  |...:|:..|.:.|.      |..|..|.:.
Mosquito  1693 RDSLY---DALESLSQNIISSLSGPAKRFYEREFDFFGKITAVSGEIRS------FPKGQARKKA 1748

  Fly  1366 C----SNLSCENTKSFSNDPE-----------DPSAAALKEPW-----------HEKEKLIRE-- 1402
            |    |.:..::.....::||           .|..:|.|.|:           .|.|.:..|
Mosquito  1749 CLEALSRIKVQSGCYLPSNPEAMVLDIDYNSGTPMQSAAKAPYLARFRVQRCGITELETMAMEVS 1813

  Fly  1403 SSPYGHLSNWRLLS--------AIVKCGDDLRQELMATQLLQMFKIIWQEEQVDLWVRPYKIVCL 1459
            ::|...:...||.|        ||.|.|||:||:::|.|::.:||.::|:..::|::.||::|..
Mosquito  1814 NNPDSQIDGPRLNSLGPEAWQAAIFKVGDDVRQDMLALQVISIFKNVFQQVGLELYLFPYRVVAT 1878

  Fly  1460 SNDSGLIEPILNTVSLHQIKKNSNKSLKEYFIDEYGSPSGESFRRAQKNFVQSCAAYCLISYLLQ 1524
            :...|:||.:.|..|..|:.:.::..|.|||:.:||..:.:.|:.|:.|||:|.|||.:|.||||
Mosquito  1879 APGCGVIECVPNAKSRDQLGRQTDFGLYEYFLHQYGDETSKEFQSARSNFVKSMAAYSVIGYLLQ 1943

  Fly  1525 VKDRHNGNILFHSDGHIIHIDFGFILSISP-KNLGFEQSPFKLTPEFVEVMGG-TSSEHWREFNK 1587
            :||||||||:...|||||||||||:...|| .|:|||.. .|||.|.|.|||| ..:..::.|..
Mosquito  1944 IKDRHNGNIMIDKDGHIIHIDFGFMFESSPGGNIGFEPD-LKLTDEMVMVMGGKMEAAPFKWFCD 2007

  Fly  1588 LLLVGMMSARKHMDRIINFVEIMRSNAHLPCFKNGCSGTVQNLRKRFHMNLTEQEMERKVEQLVQ 1652
            |.:...::.|.:.|.|:..|.:|.... ||||:   ..|:..|::||......:|....:..:::
Mosquito  2008 LCVQSFLAIRPYQDAIVTLVSLMLDTG-LPCFR---GQTITLLKQRFVPTKNSKEAAAHMLGVIR 2068

  Fly  1653 DSLKSLSTKLYDGYQYYTNGI 1673
            :|.::..|:.||..|||.|.|
Mosquito  2069 NSYQNFRTRTYDMIQYYQNQI 2089

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	112/312 (36%)
Pi4KIIIalpha	XP_061511292.1	None