Protein Alignment fwd and Pi3K92E

DIOPT Version :10

• Sequence 1: NP_001356971.1
• Gene: fwd / 45374
• FlyBaseID: FBgn0004373
• Length: 1682
• Species: Drosophila melanogaster
• Sequence 2: NP_650902.1
• Gene: Pi3K92E / 42446
• FlyBaseID: FBgn0015279
• Length: 1088
• Species: Drosophila melanogaster
• Alignment Length: 1234
• Identity: 254/1234 - (20%)
• Similarity: 432/1234 - (35%)
• Gaps: 315/1234 - (25%)

  Fly   555 DAEEECVDLMDTTSIDEEYNIMQPDHLCLYPPQAASTELDCRTLRPSRKQKRQQQQVLERKNLPS 619
            :||..|:........:|..|.:  |.:||.|   ....|:.|....:..|..:.:.|.:.|.:|.
  Fly    24 EAEPPCMRFSVNLWKNEMLNWV--DLICLLP---NGFLLELRVNPANTIQVIKVEMVNQAKQMPL 83

  Fly   620 QNQIESEDSVDAGVDARTRYRVMNMSQAAINVELGTASNEIDPDVNYRESHQDPIADAPSL---- 680
            ...|:.          ...|:|..:|  ..|:|..|       |...|.|...|.....||
  Fly    84 GYVIKE----------ACEYQVYGIS--TFNIEPYT-------DETKRLSEVQPYFGILSLGERT 129

  Fly   681 STPSVASTASATPSVTPTPIATPTPTESTKNDQVL--FKNFFGAT------KNAIFRTAQSIIEN 737
            .|.|.:|....|..|... |.|......|.....:  |:.:...|      :.:.:...|.::..
  Fly   130 DTTSFSSDYELTKMVNGM-IGTTFDHNRTHGSPEIDDFRLYMTQTCDNIELERSAYTWQQRLLYE 193

  Fly   738 HEKK--NAAKQKE--QPDHSGTVSLVGSPNGGSSVPQDLVKSPTDISKKKEFFSLLTSSSSIKAA 798
            |..:  |:.|..|  :..|.....|:            :||:..|.|.    |:|..:...
  Fly   194 HPLRLANSTKMPELIRERHPTRTFLI------------VVKNENDQST----FTLSVNEQD---- 238

  Fly   799 AAAAANSAASTPPATPTEALAANSNSKLQPLSDPSADLKVKERTLNLRLPGD---------SEGS 854
                       .|.:.||:.....|.....::|.::|..:|....:..|.||         .|..
  Fly   239 -----------TPFSLTESTLQKMNRSQMKMNDRTSDYILKVSGRDEYLLGDYPLIQFLYIQEML 292

  Fly   855 EGALTKCSSINSIHKL--------------KLPVPGVVKYFISEKAPVSDVLQKPEKGQSGLLRF 905
            ..:......:.|:::|              |.|:|        :|..|.  |.|.......:..:
  Fly   293 SDSAVPNVVLQSVYRLESYINHHNEQAMVTKRPLP--------KKRTVH--LHKSISSLWDMGNY 347

  Fly   906 FE---SPVFNIHF--------AVHYLFYSKEPGVLSFIGNKIFSFPDQEVDLYIPQLVVM--YIQ 957
            |:   ..:.|::|        .||...|.   |.......:....|:...|.::...:||  .||
  Fly   348 FQLTLHSISNVNFDKTRALKVGVHVCLYH---GDKKLCAQRSTDSPNGNFDTFLFNDLVMDFDIQ 409

  Fly   958 MDELAEVLDPYLTIRCRKSVDFSLKCLWLLEAYNYQVDSLGNSHNSSRKSKLALMKEIFSKREHK 1022
            |..|     |.:|..|               ...::|..:..|..||....:||....::|
  Fly   410 MRNL-----PRMTRLC---------------IVIFEVTKMSRSKKSSNNKDIALKDVPYNK---- 450

  Fly  1023 QTQNDLKSAGTGGLHVGEPRSVVALAKKTHHRSQSDATVLLADFRSPHTLSISHRMYQQPPYTTQ 1087
               |.|....|   .:.:.:.::...:.|.:      |...||  ...::.:.|.:        .
  Fly   451 ---NPLAWVNT---TIFDHKDILRTGRHTLY------TWTYAD--DIQSVEVFHPL--------G 493

  Fly  1088 TLPTTPAK--LCLGDLT---SG-----HAFDNGCTCFETVRGQVNGLLGQRTLCSCGAPKTSPQK 1142
            |:...|.|  ..|.|||   ||     :..:.....:...|.|||.|  ||.|    |....|.|
  Fly   494 TIEPNPRKEECALVDLTFLSSGTGTVRYPSEEVVLQYAADREQVNRL--QRQL----AGPEKPIK 552

  Fly  1143 EFMKALMNVGKNLTSWPSKAEKTSALRMSL----NLINKNLP------------------ARVWL 1185
            | :|.||   .|.|......|.....|.::    |.|.:.||                  |.:|.
  Fly   553 E-LKELM---ANYTGLDKIYEMVDQDRNAIWERRNDILRELPEELSILLHCVYWKERDDVADMWY 613

  Fly  1186 -----PLYS----------DIPHHVVRITEEKTAV-----LNSKDKTPYII-YVEVVEIPDIYTS 1229
                 ||.|          ..|...||    :.|:     |..:|...|:: .|:.::......|
  Fly   614 LLKQWPLISIERSLELLDYAYPDPAVR----RFAIRCLHFLKDEDLLLYLLQLVQAIKHESYLES 674

  Fly  1230 PLIPKMMP-SLRHTKSEEHLDGSCLNSHQHLSCSRTSSCSSSQQGTSCRRKKGADVD---GGCGD 1290
            .|:..::. :||:.:...:.       ..||        .|..|..|.:.:.|..::   .||
  Fly   675 DLVVFLLERALRNQRIGHYF-------FWHL--------RSEMQTPSMQTRFGLLLEVYLKGC-- 722

  Fly  1291 AGPHNSCSNVHSLGGLQFQEDDVWSQEEDEITAQYLNMRKVSERDTISQISLDSCDSRDQGPPVV 1355
                     .|.:..|:.|...:...::..:.|:..:..||.   |:.|..|     |||....|
  Fly   723 ---------KHHVAPLRKQLHVLEKLKQGSLIAKKGSKEKVK---TMLQDFL-----RDQRNSAV 770

  Fly  1356 FNIGDVRLR---HCSNLSCENTKSFSNDPEDPSAAALKEPWHEKEKLIRESSPYGHLSNWRLLSA 1417
            |......|.   .||.::.:..|...        :.::..|     ::.|::..    |...:..
  Fly   771 FQNIQNPLNPSFRCSGVTPDRCKVMD--------SKMRPLW-----VVFENADV----NASDVHI 818

  Fly  1418 IVKCGDDLRQELMATQLLQMFKIIWQEEQVDLWVRPYKIVCLSNDSGLIEPILNTVSLHQIKKNS 1482
            |.|.||||||:::..|:|::...:|:.:.:|..:..|..:.:....|:||.:.:..::..|:|..
  Fly   819 IFKNGDDLRQDMLTLQMLRVMDQLWKRDGMDFRMNIYNCISMEKSLGMIEVVRHAETIANIQKEK 883

  Fly  1483 ---------NKSLKEYFIDEYGSPSGESFRRAQKNFVQSCAAYCLISYLLQVKDRHNGNILFHSD 1538
                     .|.....::.|:..|: :...:|...|..|||.||:.:|:|.|.|||:.||:...:
  Fly   884 GMFSATSPFKKGSLLSWLKEHNKPA-DKLNKAINEFTLSCAGYCVATYVLGVADRHSDNIMVKRN 947

  Fly  1539 GHIIHIDFGFILSISPKNLGF--EQSPFKLTPEFVEVM----GGTSSEHWREFNKLLLVGMMSAR 1597
            |.:.|||||.||....:.||.  |:.||.||.:||.|:    ....|:.:..|.:|.....:..|
  Fly   948 GQLFHIDFGHILGHFKEKLGVRRERVPFVLTHDFVYVINKGFNDRESKEFCHFQELCERAFLVLR 1012

  Fly  1598 KHMDRIINFVEIMRSNAHLPCFKNGCSGTVQNLRKRFHMNLTEQE----MERKVEQLVQDSLKS 1657
            ||...|::...:|.|.. ||  :......:..||:...::.||::    ...|..:.:.:|.|:
  Fly  1013 KHGCLILSLFSMMISTG-LP--ELSSEKDLDYLRETLVLDYTEEKAREHFRAKFSEALANSWKT 1073

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
fwd	NP_001356971.1	PI4Kc_III_beta	1385..1674	CDD:270712	75/292 (26%)
Pi3K92E	NP_650902.1	PI3K_p85B	56..132	CDD:470589	19/94 (20%)
		PI3K_rbd	200..307	CDD:197540	23/137 (17%)
		C2_PI3K_class_I_beta_delta	339..517	CDD:176075	42/226 (19%)
		PI3Ka_I	552..723	CDD:238444	38/204 (19%)
		PI3Kc_I	727..1084	CDD:270709	92/376 (24%)