DRSC/TRiP Functional Genomics Resources

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Protein Alignment fwd and pik3cg

DIOPT Version :9

Sequence 1:NP_001356971.1 Gene:fwd / 45374 FlyBaseID:FBgn0004373 Length:1682 Species:Drosophila melanogaster
Sequence 2:XP_021330656.1 Gene:pik3cg / 406598 ZFINID:ZDB-GENE-040426-2532 Length:1113 Species:Danio rerio


Alignment Length:1191 Identity:244/1191 - (20%)
Similarity:422/1191 - (35%) Gaps:337/1191 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly   543 ESLDSGEMDADAD--AEEECVDL----MDTTSIDEEYNIMQPDHLCL-----------YPPQAAS 590
            ::||:.::|...:  .|:..|.|    :.:....|.|....||:..|           |..|...
Zfish    68 KTLDTLQLDVTGNWTVEQVKVQLWHRAVTSKLCPEFYQKYSPDYCILLYQKKGNWYEIYDKQQVF 132

  Fly   591 TELDC-RTLRPSRKQKRQQQQVLERKNLPSQNQIESEDSVDAGVDARTRYRVMNMSQAAINVELG 654
            ..||| |..:..||...:...|:.::  |:::.::.:             |.:|   ..|..::.
Zfish   133 QTLDCIRYWKALRKDVGKIHLVVRQQ--PAEDSLQYQ-------------RFLN---HLIGYDVT 179

  Fly   655 TASNEIDPDVNYRESHQDPIADAPSLSTPSVASTASATP---SVTPTPIATPTPTESTKNDQVLF 716
            ..||..|.::.:...         .|.||.....:...|   |:.|....||.|      :.:|.
Zfish   180 DVSNVHDDELEFTRR---------KLLTPRKIELSDRDPNLYSMDPWMTTTPMP------EYLLS 229

  Fly   717 KNFFGATKNAIFRTAQSIIENHEKKNAAKQKEQPDHSGTVSLVGSPNGGSSVPQDLVKSPTDISK 781
            |                |..||..  ....||....:..||:..:|                :..
Zfish   230 K----------------ISNNHIL--MVIHKETTSQTIKVSIDDTP----------------VQV 260

  Fly   782 KKEFFSLLTSSSSIKAAAAAAANSAASTPPATPTEALAANSNSK------------------LQP 828
            .:.||:.:|:..::...:...:.|..........|.|..|:..|                  |:.
Zfish   261 LQSFFAKITNKRALLGISEDVSESDFVLRVCGREEYLYGNNAIKDFHWIRQCLKNGEEIHLVLEH 325

  Fly   829 LSDPSADLKVKERTLNLRLPGDSEGSEGALTKCSSINSIH-------------KLKLPVPGVVKY 880
            ..:|..|:..||....:   .|..|..|...:.:.....|             |.::.:.|:   
Zfish   326 PPNPEQDVVQKEDWSQV---DDCTGVAGTHEQLTITEKDHEKVFTISLWDCNRKFRVKILGI--- 384

  Fly   881 FISEKAPVSDVLQKPEKGQSGLLRFFESPVFNIHFAVHYLFYSKEPGVLSFIGNKIFSFPDQEVD 945
                     |:...|.  .|.|:.|.|:.:|:....:.....|.:|.....|.|....|      
Zfish   385 ---------DIPVLPR--NSELIVFVEASIFHGQQLLAQERTSSKPFTEEVIWNTWLEF------ 432

  Fly   946 LYIPQLVVMYIQMDELAEVLDPYLTIRCRKSVDFSLKCLWLLEAYN-----YQVDSLGNSHNS-S 1004
                     .|::.:|.:.....|.:.|.|:...:.|   ..|..|     |.|:.|...|.| .
Zfish   433 ---------NIKIKDLPKGARLSLQVSCGKAQTQTSK---ETECKNKSRLLYYVNLLLVDHRSLL 485

  Fly  1005 RKSKLAL-MKEIFSKREHKQTQN-DLKSAGTGGLHVGEPRSVVALAKKTHHRSQSDATVLLADFR 1067
            |:.:..| |.::..|.|...:.| |..::.|.    .:..:.:|:|            :||..:.
Zfish   486 RQGEFILHMWKMPEKSEDNSSVNADKLTSATN----PDKNNSMAVA------------ILLDKYC 534

  Fly  1068 SPHTLSIS--------HRMYQQPPYTTQTLPTTPAKLCLGDLTSGHAFDNGCTCFETVRGQVNGL 1124
            .|..|..|        .|..::.|                    .|           :|.|...:
Zfish   535 YPVALPKSKDSPDIEGERGQREMP--------------------NH-----------LRKQFEQI 568

  Fly  1125 LGQRTLCSCGAPKTSPQKE----FMKALMNVGKNLTSWPSKAE--KTSALRMSLNLINKNLPARV 1183
            :....|    .|.||..||    |.:..|...|....:.|..:  |..|:.::..|:.:   :.:
Zfish   569 IATDPL----HPLTSEDKELLWHFRQECMRDPKAYPKFLSSVKWGKQEAVAITHYLLER---STI 626

  Fly  1184 W----------LPL----YSDIPHHVVRITEEKTAVLNSKDKTPYII-YVEVVEIPDIYTSPLIP 1233
            |          |.|    :||  .:|..|...|...|...|...|:: .|:.|:....:.|.|..
Zfish   627 WDRSVLDVGLVLQLLDCHFSD--ENVRTIAVRKLETLGDDDVLRYLLQLVQAVKFEPYHDSALAR 689

  Fly  1234 KMMPSLRHTKSEEHLDGSCLNSHQHLSCSRTSSCSSSQQGTSCRRKKGADVDG---GCGDAGPHN 1295
            .::.....:|...|.....|.             |...|....:::....::.   |||:     
Zfish   690 FLLKRALRSKRIGHFLFWFLR-------------SEIAQSMHYQQRYAVILEAYLRGCGE----- 736

  Fly  1296 SCSNVHSLGGLQFQEDDVWSQEEDEITAQYLNMRKVSERDTISQISLDSCDSRDQGPPVVFNIGD 1360
                       :..:|   .:::.|||..   ::||:..  |.|||.:..|...|   |||.:..
Zfish   737 -----------EMLQD---FRKQVEITEA---LQKVARE--IKQISAEKYDISAQ---VVFQLRQ 779

  Fly  1361 VRLRHCSNLSCENTKSFSNDPEDPS--AAAL-----------KEP-WHEKEKLIRESSPYGHLSN 1411
             :|.....|...:  || ..|.||.  |.||           |:| |.:    .:.:.|....|:
Zfish   780 -KLEGLQVLGLPD--SF-KVPYDPGLRAGALVIEQCKVMASKKKPLWLQ----FKRADPTTLSSD 836

  Fly  1412 WRLLSAIVKCGDDLRQELMATQLLQMFKIIWQEEQVDLWVRPYKIVCLSNDSGLIEPILNTVSLH 1476
              .:..|.|.||||||:::..|:|.:.:.||:.|.:||.:.||..:...|..|:||.:.:..::.
Zfish   837 --TIGIIFKDGDDLRQDMLILQILLIMESIWELESLDLSLLPYGCISTGNKIGMIEIVKDATTIA 899

  Fly  1477 QIKKNS------------NKSLKEYFIDEYGSPSGESFRRAQKNFVQSCAAYCLISYLLQVKDRH 1529
            .|::::            ::.|:|..::|      :..::|...||.||..||:.:|:|.:.|||
Zfish   900 NIQQSTVGNTGAFKDEILSQWLREKCVNE------DKHQQAVDRFVFSCGGYCVATYVLGIGDRH 958

  Fly  1530 NGNILFHSDGHIIHIDFGFILSISPKNLGF--EQSPFKLTPEFVEVMGGT---SSEHWREFNKLL 1589
            |.||:....|::.|||||.||......||.  |:.||.|||:|:.:||.|   ||.::.:|..:.
Zfish   959 NDNIMITETGNLFHIDFGHILGNYKSFLGISKERVPFVLTPDFLYLMGTTGKKSSPNFLQFQNVC 1023

  Fly  1590 LVGMMSARKHMDRIINFVEIM 1610
            |...::.|.|.:.:|....:|
Zfish  1024 LKAYLALRHHTNLLIILFSMM 1044

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fwdNP_001356971.1 PI4Kc_III_beta 1385..1674 CDD:270712 76/257 (30%)
pik3cgXP_021330656.1 PI3K_rbd 221..327 CDD:307097 22/145 (15%)
C2_PI3K_class_I_gamma 366..537 CDD:176044 39/218 (18%)
PI3Ka_I 559..735 CDD:238444 37/208 (18%)
PI3Kc_IB_gamma 739..1105 CDD:270627 98/333 (29%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_COG5032
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
21.810

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